Rubin_Dasgupta

#NMR spectroscopist studying bio-macromolecules proteins, RNA and DNA

[Rubin_Dasgupta @DasguptaRubin]

@timesofindia @abandopa Are we surprised of this? Viksit Bharat should have strong immune system 😅

[Rubin_Dasgupta @DasguptaRubin]

@isabellaxfaria What about the science? Does it seem good? Did the author provide links to the raw data or codes? Are all the plots and interpretation of the data good? If yes then rejecting just on the basis of writing might be too harsh. A major revision. If not then rejection.

[Rubin_Dasgupta @DasguptaRubin]

@BiologyAIDaily Interesting approach

[Rubin_Dasgupta @DasguptaRubin]

@DNPFred @fscottdnp @NationalMagLab Amazing study. Will other sugars behave similarly? For e.g. trehalose and/or mannitol

[Rubin_Dasgupta @DasguptaRubin]

Amazing poster indeed! Looking forward to discuss all things related to Argonaute.

[Kotaro Nakanishi @ktr_nakanishi]

This is a cool conference poster✨
https://t.co/cyZHdDKSi2

[Rubin_Dasgupta @DasguptaRubin]

@loquet_lab @maer @iecb_bordeaux @CNRSchimie Yeah PDSD/DARR is easy to implement however, the editing capability of DREAM is very interesting. The specific-CP in hNCC to study ribose in RNA is challenging under DNP. It will be nice if one can use hCC DREAM to do the editing and study the ribose

[Rubin_Dasgupta @DasguptaRubin]

@bertivogele For sure depleted glycerol will be of big advantage here. Similar thing happens for me as well and all the ribose 13C resonances (except C1') are completely overshadowed by glycerol which is 60% of the total sample volume.

[Rubin_Dasgupta @DasguptaRubin]

@bertivogele Yes I can relate with this so much!!!

[Rubin_Dasgupta @DasguptaRubin]

@bertivogele 😅 Indeed, I had a notion (which now it seems is wrong) that DNP community uses 13C depleted glycerol more often

[Rubin_Dasgupta @DasguptaRubin]

@bertivogele Yes sure! I will be on the lookout. Its quite interesting that 12C, d8-glycerol was available in the past and I wonder what happened that CIL cannot provide it anymore. Change in production lineup or chemistry?

[Rubin_Dasgupta @DasguptaRubin]

@bertivogele 😅

[Rubin_Dasgupta @DasguptaRubin]

@bertivogele Anyways I think at this point it’s worth trying FEDex or TRAPDORED sequences to perform solvent suppression

[Rubin_Dasgupta @DasguptaRubin]

@Fred_A_Perras Really cool comparison!!! Thanks @Fred_A_Perras. Just one question, how does this comparison hold for different versions of REDOR for e.g. Time-shifted or Sine-squared shifted REDOR? Also, thank you for providing the SIMPSON code (a great learning resource)

[Rubin_Dasgupta @DasguptaRubin]

Interesting paper where the N-terminal domain of GW182/TNRC6 can bind CCR4-NOT via the CNOT9 and not only the C-terminal silencing domain. This might be one of the possible mechanism to transfer information from Ago2 to CCR4-NOT. #argonaute #microrna

https://t.co/snotuq8JUX

[Rubin_Dasgupta @DasguptaRubin]

@ProfessorAntony @Rajnandani_15 Really cool work. Very fascinated with the discovery of Fe-S clusters in proteins involved in nucleic acid regulation and why nature selected these proteins to have a source of ROS close to genetic material.

[Rubin_Dasgupta @DasguptaRubin]

@Fall_of_Civ_Pod @blackwellbooks Waiting eagerly for the book in Stockholm

[Rubin_Dasgupta @DasguptaRubin]

Presented our recent discovery at my first @ENC_Conf. Amazing experience and great discussions. Thank you organisers for this great experience.

[Rubin_Dasgupta @DasguptaRubin]

@ENC_Conf and solar eclipse with perfect weather