Dimitrios Davalos & Lab

We study how immune mechanisms affect physiological brain function & the onset of neurological diseases. @davalos.bsky.social these days

[Dr. Saba Valadkhan @SValadkhan]

Excited to share our new manuscript in @NatureMicrobiol uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival 🧵 #HIVresearch

[Giulio Maria Pasinetti, MD, PhD @IcahnCMIN]

Findings by researchers @pryprk @palakmanchanda4 @DavalosLab, Gaurav Chopra, et al. show that excess fat in the brain’s resident immune cells, #Microglia, impairs their ability to combat disease. Learn More in @ImmunityCP 👉 https://t.co/7a0zNsZaH8

[Dimitrios Davalos & Lab @DavalosLab]

Thank you for giving life to our sketch Emma! Until next time!

[DrawImpacts @DrawImpacts]

A real pleasure collaborating with you and the team, @DavalosLab @pryprk — congratulations on the publication! Looking forward to future opportunities to work together again ✨

[Dimitrios Davalos & Lab @DavalosLab]

Emma Vidal brought our concept to life.
For more info about the cool science produced in the @chopralab and ours, that inspired our geeky illustration, please read the paper here: https://t.co/AUkpdSXBIg

[Dimitrios Davalos & Lab @DavalosLab]

Microglia: Super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (weights) & lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @ImmunityCP

[Dimitrios Davalos & Lab @DavalosLab]

But blocking or reducing DGAT2 (using a cool new drug developed by @chopralab ) restores microglial phagocytosis of Aβ and thereby reduces plaque load and neuronal damage in a preclinical model of #Alzheimer’sDisease.

[Evi Paouri @EviPaouri]

Super proud to have been part of this work between the @chopralab and the @DavalosLab that is now published @ImmunityCP !!! Thank you @pryprk, Palak Manchanda, and all authors for this extraordinary collaboration!!!

[Dimitrios Davalos & Lab @DavalosLab]

@sciqst @ImmunityCP Thank you for your kind words! Please check out a paragraph in our discussion on exactly your question: how systemic complications are a serious consideration for manipulations of metabolic pathways in general and why we think DGAT2 may be different @chopralab is on this mission!

[Dimitrios Davalos & Lab @DavalosLab]

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Check out our manuscript @ImmunityCP 👇🏼
https://t.co/AUkpdSXBIg

[Dimitrios Davalos & Lab @DavalosLab]

@jonykipnis @ImmunityCP Thank you Jony! Gaurav Chopra and an entire village of folks in the @chopralab and mine deserve all the credit!

[Dimitrios Davalos & Lab @DavalosLab]

@OlegButovsky @ImmunityCP Thank you very much for your kind words @OlegButovsky! We are also very excited to see this through with Gaurav @chopralab and everyone involved with this project!

[Dimitrios Davalos & Lab @DavalosLab]

Tremendously grateful to an amazing team of lab members and collaborators including @pryprk , @EviPaouri , Palak Manchanda and Gaurav @chopralab and pretty much all Chopra and Davalos Lab members for the smooth teamwork @ClevelandClinic @CCLRI @PurdueUnivNews

[Dimitrios Davalos & Lab @DavalosLab]

It was💯fun to co-author this commentary w/ Katerina & other current & former fibrinogen mates from @AkassoglouLab for Cell’s 50th anniversary neuroscience issue: @CellCellPress: Pioneering discovery and therapeutics at the brain-vascular-immune interface: https://t.co/YOUIr8ZHuk

[Justin Lathia, PhD 🧠🕺🏽 @JustinLathia]

Great hosting @fib390_396A for our @CCLRI department seminar tomorrow, awesome dinner with @DavalosLab @2Scottish talking about all things platelets and thrombosis - looking forward to the seminar tomorrow morning at 10 AM, NC1-202

[Dimitrios Davalos & Lab @DavalosLab]

Always have perspective!

[Curiosity @CuriosityonX]

A gentle reminder!

[Nima Sharifi @NimaSharifiMD]

Are you doing exciting mechanistic science or translational work? Join us in #Miami! We are looking for independent investigators at all levels! ⁦@ASBMB⁩ ⁦@thepostdoctoral⁩ ⁦@AACR⁩ Faculty Positions - U of Miami ⁦@umiamimedicine⁩ https://t.co/MUAp3m9LNy

[Lasker Foundation @LaskerFDN]

C. David Allis and Michael Grunstein won the 2018 Basic #LaskerAward for discovering how histone modifications influence gene expression. https://t.co/T5TXDnzp9a @RockefellerUniv @UCLA
In just 5 days, we reveal the scientific breakthroughs recognized this year. #Lasker2024

[Dimitrios Davalos & Lab @DavalosLab]

Amazing new study @nature showing that fibrin drives lung inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with acute COVID-19 and long COVID! Congrats @AkassoglouLab & collaborators!

[Katerina Akassoglou @AkassoglouLab]

Our new paper is out @Nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody
#LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19
https://t.co/b16uIzqHOJ

[Erik A. Rodriguez @erin_rod_phd]

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday
https://t.co/YdWfBPUOBB