David Cook

Ovarian cancer, Single-cell genomics, Cell plasticity |
Scientist, Cancer Therapeutics, @OttawaHospital |
Assistant Professor, @OttawaCMM

[David Cook @DavidPCook]

Excited to announce the Cook Lab will be opening at the Ottawa Hospital Research Institute Jan 2024. We'll be focusing on intratumoural heterogeneity and therapy resistance in ovarian cancer

Eager to work more with the ovarian cancer research community!

https://t.co/p11SFo7ayP

[Sergey Isaev @sv_isaev]

Hey Twitter!

~2 yrs ago we dropped a preprint on clonal analysis of mouse development. During revisions the computational side grew so much we split it in two: experimental & computational. Today's thread is about the latter. Let's dig in 🧵 https://t.co/ljZkR9z063

[Livnat Jerby @LivnatJerby]

Excited to share our paper on engineering spatially targeted immune cells is now out in @NatImmunol. https://t.co/pVIt7p3t61

#CRISPR activation screens reveal that engineering metabolite-sensing NK and T cells provides programmable mechanisms to target solid tumors.

Congrats to @komong0702, Mike Tsai, and the team!

Thanks to @ocrahope, @StanfordCancer, @AllenInstitute, @BWFUND, @czbiohub, @genome_gov, Tull Family Foundation, @stanfordcbio, @Stanford Genetics and @StanfordMed for the support.

[David Cook @DavidPCook]

Thanks University of Ottawa for highlighting our work to improve outcomes for women with gynecologic disease. March is Endometriosis Awareness Month and it means a lot to see this focus not just on the science, but the patients who drive it.

[uOttawa | Innovation @uOttawaResearch]

🏆 Recipient of the Polanyi Prize in Physiology and Medicine for excellence in early-career research, Professor David Cook is advancing research into gynecologic diseases and paving the way for better healthcare for women.

🔗 https://t.co/XZxgTUXkW9

[Michael Vinyard @vinyard_m]

I just updated the scDiffEq Python API (v1.1.0) to include animated visualizations of simulations.

You can generate GIFs (or still images) showing:

- Temporal gene expression dynamics
- UMAP projections of simulated trajectories

During my PhD, I found animations like these useful in presentations.

Available now in the latest release: https://t.co/Wkl0My7xT8

[Kole Roybal @KoleRoybal]

Excited to share our recent manuscript out at @Nature . @piraner and @majo__duran from @roybal_lab and @Mohamad_Abedi and @AdamChazin in David Baker's lab engineered synthetic receptors that sense natural and designer soluble cues. https://t.co/9Ezof5OFGf

[David Cook @DavidPCook]

@vlorenzi3 @RArgelaguet @biorxivpreprint @ceci_icoresi @LuzGarAl @roserventotormo @MarioniLab Wow amazing! I’ve been dying to see a study like this on mullerian development/regression. Can’t wait to read. Congrats!

[vlorenzi @vlorenzi3]

📢Excited to share our work on @biorxivpreprint "Spatiotemporal map of the developing human reproductive tract at single-cell resolution"! Beyond grateful to our amazing team @ceci_icoresi @LuzGarAl @roserventotormo @MarioniLab and collaborators for their contributions. 🧵[1/10]

[Isabel Puig Borreil @IPuigBorreil]

A protein expression atlas on tissue samples and cell lines from cancer patients provides insights into tumor heterogeneity and dependencies. https://t.co/bD85EUK910

[Simon Duerr @simonduerr]

This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) https://t.co/qYzIsbr0TH

[David Cook @DavidPCook]

@Kalzahrani071 @SRC_CRS Ahh!! Incredibly well deserved. Huge congrats! 🍾🎉

[David Cook @DavidPCook]

@c_mccloskey1 @SRC_CRS @OvarianCanada Woooohoo! Big congrats 🎉 🎉 Looking forward to seeing what you have in store! 👀

[Jimmie Ye @yimmieg]

1/🧵Excited to re-introduce Memento in (https://t.co/mxycmsOTkr), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇

[Lukas Valihrach @LukasValihrach]

Interactive design and validation of antibody panels using single-cell RNA-seq atlases https://t.co/A7dngDK6Xq

[Lukas Valihrach @LukasValihrach]

snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives👏 https://t.co/LNm707hav6

[Tullia Bruno, PhD @BcellBruno]

Happy publication day for us! Labor of love with @CoffmanLab #TLS #ovariancancer @UPMCHillmanCC @PittTweet
The activity of tertiary lymphoid structures in high grade serous ovar... https://t.co/UAb4uIQaBH

[Shalek Lab @shaleklab]

🚀 Excited to share our new publication in @NatureBiotech! We explore scalable strategies for phenotypic screening using innovative methods with to address the challenges when the number of candidates is simply too large. Check out the details https://t.co/C0oan6L18a! (1/10)

[Luciano Martelotto 🛠🧬💻🇦🇺 @LGMartelotto]

STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging | bioRxiv

⁦@DrJasPlummer⁩ ⁦@hoheyn⁩ ⁦@pascual_reguant⁩ ⁦@eliseinsing⁩ ⁦@cnag_eu⁩ ⁦@ACEpigenetics⁩ ⁦@StJudeResearch⁩ https://t.co/Kd23iqafi7

[Denis Wirtz @deniswirtz]

3D cellular CODA maps of the fallopian tube are used to guide the design of "assembloids" that recapitulate the complex architecture and ciliated-based motion of oocytes.

See more here: https://t.co/skhlSCXBDx

[Luciano Martelotto 🛠🧬💻🇦🇺 @LGMartelotto]

FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics | Nature Methods https://t.co/kALcpV8Raa

[Luciano Martelotto 🛠🧬💻🇦🇺 @LGMartelotto]

FixNCut: A Practical Guide to Sample Preservation by Reversible Fixation for Single Cell Assays https://t.co/ylAXasje7T