David P. Labbé, PhD

Associate Professor and William Dawson Scholar @mcgillu, focused on understanding the relation between #diet and #ProstateCancer.

[David P. Labbé, PhD @DavidP_Labbe]

Thrilled to share our study in @CR_AACR! #Obesogenic high-fat diet (HFD) and #MYC cooperate to promote lactate accumulation and TME remodeling in #prostatecancer. Co-first authors @BoufNadia and Paolo Chetta. Co-lead @ZadraGiorgia + 30 co-authors!
https://t.co/6owwtKMqwn
(1/17)

[David P. Labbé, PhD @DavidP_Labbe]

Merci beaucoup à @RIMUHC1 , au @McGillDeptSurg de @mcgillu et au @FRQS1 pour ce soutien. Je suis honoré de faire partie de cette cohorte et reconnaissant envers mon équipe, mes collaborateurs et organismes subventionnaires.

Félicitations à toutes et tous les lauréats!

[Research Institute of the MUHC (The Institute) @RIMUHC1]

🎉 15 chercheuses et chercheurs de L'Institut ont reçu une subvention salariale du @FRQS1 — plus de 2,5 M$ pour des travaux couvrant le cancer, les maladies infectieuses, la santé des enfants, la neurologie, la santé maternelle, et plus encore!
👉 https://t.co/qU5FzQ4ZBq

[David P. Labbé, PhD @DavidP_Labbe]

Many thanks to the @RIMUHC1, the @McGillDeptSurg of @mcgillu and the @FRQS1 for this support. I’m honoured to be part of this cohort and grateful to my team, collaborators and funders.

Congratulations to all the awardees!

[Research Institute of the MUHC (The Institute) @RIMUHC1]

🎉 15 researchers at The Institute have received @FRQS1 salary awards — more than $2.5M for work spanning cancer, infectious diseases, child health, neurology, maternal health, and more. Congratulations to all recipients!
👉 https://t.co/dO3IxnkDPn

[David P. Labbé, PhD @DavidP_Labbe]

@PingMu_PhD Congrats Ping!

[David P. Labbé, PhD @DavidP_Labbe]

@cusm_muhc @McGillMed @PCF_Science @urotoday @UrologySBUR @TheAACU @Uroweb

[David P. Labbé, PhD @DavidP_Labbe]

🚨 Exciting leadership opportunity at @McGillU / @MUHC: Associate/Full Professor (Clinical) to serve as Director of the Division of #Urology & Director of #Urology at the MUHC (@McGillDeptSurg).

Apply here: https://t.co/30UFdXRb4K

Please RT/share and come join us in Montréal🇨🇦!

[David P. Labbé, PhD @DavidP_Labbe]

🚨 New Review in Gene!
Therapy-Induced Senescence in Prostate Cancer
✔ Mechanisms & biomarkers
✔ Dual role of TIS: tumor-suppressive vs. tumor-promoting
✔ Senolytics & senomorphics as next-gen strategies
✔ Clinical trials & future directions
🔗 https://t.co/L1lzzn1SFm

[Francesca Zacchi @FrancescaZacc14]

🚨 Published our #Review on Senescence in Prostate Cancer!
Honored to be part of this collaboration with outstanding colleagues! @quimmateo @julianbrandariz @luisa_bacc76421 @DavidP_Labbe AndreaZivi
#Oncology #CancerResearch #Senescence #ProstateCancer https://t.co/sKE3hwLwuY

[David P. Labbé, PhD @DavidP_Labbe]

We are hiring a 👩‍🔬 Research Assistant 👨‍🔬 to work on cutting-edge dietary interventions to potentiate DNA damaging therapies in prostate cancer.
Come working with us at the @CUSM_MUHC @McGillDeptSurg @mcgillu!
Please share: https://t.co/H2plgM6GUf
@UrologySBUR @PCF_Science

[David P. Labbé, PhD @DavidP_Labbe]

It is an honour to be listed among this list of outstanding prostate cancer scientists!
@mcgillu @RIMUHC1 @McGillDeptSurg @MUHCFoundation @CedarsCancer

[OncoDaily @oncodaily]

📌Top 100 Xfluencers in Prostate Cancer: Key Opinion Leaders to follow on X (Twitter) in 2024

September was a significant month dedicated to raising awareness about various cancers, and Prostate Cancer was a key focus. In an effort to celebrate the #ProstateCancer Awareness Month, OncoDaily has curated the Top 100 Xfluencers in Prostate Cancer: Key Opinion Leaders to follow on X (Twitter).

https://t.co/nJ8gF5tAMj

[David P. Labbé, PhD @DavidP_Labbe]

@PingMu_PhD @Yale_Urology @YaleMed @YaleCancer @Yale Congrats Ping and welcome back to the ET time zone!!!

[David P. Labbé, PhD @DavidP_Labbe]

It was a pleasure to meet and discuss research with like-minded scientists on a mission to make a difference for patients with urological diseases at the #URS2024 meeting hosted at @YaleMed! Thanks for the invitation and the great time!

[David P. Labbé, PhD @DavidP_Labbe]

@PingMu_PhD This is a very good one! Congrats on getting there (I talk from 1 extra year of experience)!

[Advanced Prostate Cancer Consensus Conference @APCCC_Lugano]

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
out on @CR_AACR

https://t.co/jXuBDoFS1c

Study explores how systemic metabolism, particularly through a high-fat diet (HFD) rich in saturated fats, accelerates c-MYC-driven #ProstateCancer progression by rewiring tumor metabolism.

In a mouse model🐭the combination of c-MYC🧬 activation and an obesogenic HFD led to increased glycolysis and lactate accumulation in tumors, which promoted immune changes, including higher infiltration of tumor-associated macrophages and regulatory T cells. These alterations contributed to tumor growth, therapy resistance, and angiogenesis, which were reduced by lactate dehydrogenase inhibition.

Clinical data🥼 revealed similar tumor metabolic shifts in prostate cancer patients with high saturated fat intake, suggesting lactate's potential as a biomarker and target for dietary and therapeutic interventions in advanced prostate cancer.

@RIMUHC1
@BoufNadia
@Carole_Luthold
@eddieimada of @WCMCPathology
@Davicioni
@DrSpratticus
Lisa M. Butler of @UniofAdelaide
Massimo Loda of @WeillCornell
@DavidP_Labbe
@ZadraGiorgia

[David P. Labbé, PhD @DavidP_Labbe]

Thanks to the Marathon of Hope Cancer Centres Network for this outstanding opportunity to help improve the efficacy of prostate cancer treatments through lifestyle interventions!

[Marathon of Hope Cancer Centres Network @marathonofhope]

Can personalized lifestyle interventions help improve the efficacy of prostate cancer treatments? 🥑 🏃‍♂️ 🥕

A new team of pan-Canadian researchers is hoping to answer this question thanks to new funding from the @MarathonOfHope Cancer Centres Network (🧵1/3)

[David P. Labbé, PhD @DavidP_Labbe]

@ThePennLab @alannahskye23 @PMResearch_UHN @UofT Congrats Alannah and the Penn lab!!!

[Prostate Cell News @ProstateCell]

Drs. @DavidP_Labbe & @ZadraGiorgia's team, led by Drs. @BoufNadia & Paolo Chetta, showed that an obesogenic high fat diet 🍟 🍔 rich in saturated fats promotes the development of c-MYC–driven invasive #ProstateCancer through metabolic rewiring. @RIMUHC1

https://t.co/k9qkUyqbrL

[David P. Labbé, PhD @DavidP_Labbe]

@kazaklab @Parklabmcgillu @thomas_duchaine @McGillGCI @mcgillu Congratulations Lawrence, this is very well deserved! 🍾

[David P. Labbé, PhD @DavidP_Labbe]

@MariannKruithof Thanks Marianna! ☺️

[David P. Labbé, PhD @DavidP_Labbe]

@AdamSharpMedOnc @CR_AACR @BoufNadia @ZadraGiorgia Thanks Adam! Hopefully this will provide additional rationale to capture lifestyle / diet data in the clinic so that we can really delve into an era of precision nutrition in prostate cancer prevention, detection and treatment.

[David P. Labbé, PhD @DavidP_Labbe]

Thrilled to share our study in @CR_AACR! #Obesogenic high-fat diet (HFD) and #MYC cooperate to promote lactate accumulation and TME remodeling in #prostatecancer. Co-first authors @BoufNadia and Paolo Chetta. Co-lead @ZadraGiorgia + 30 co-authors!
https://t.co/6owwtKMqwn
(1/17)

[David P. Labbé, PhD @DavidP_Labbe]

@MariannKruithof @CR_AACR @BoufNadia @ZadraGiorgia Thanks Marianna!

[David P. Labbé, PhD @DavidP_Labbe]

@DanielFrigo @ZadraGiorgia @BoufNadia You did! It is an honor to have our work covered by your thorough and insightful comment, thank you!