Hsieh Lab

A lab @FredHutch obsessed with translation control and its impact on health and disease. #mRNAtranslation #prostatecancer #bladdercancer #physicianscientist

[Hsieh Lab @HsiehLab]

Ever wonder if tRNAs can regulate the identity of a cancer cell?

@HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: https://t.co/V7FHTM0l5M

[Science in Seattle @science_seattle]

A study shows that a single tRNA helps determine if #ProstateCancer remains treatment-sensitive or becomes resistant, opening new avenues in #PrecisionOncology.

🥼Abstract by Drs. Yeon Soo Kim & Andrew Hsieh at @fredhutch: https://t.co/iK51HVL7rG
📰News: https://t.co/OZAI4kHXkJ

[Hao Zhu Lab @Zhu_Lab]

We are looking to hire post-doctoral fellows to work on somatic mosaicism, regeneration, and cancer development, please reach out to me if you are interested! @CRI_UTSW

[Fred Hutch Cancer Center @fredhutch]

Ready to lead the next wave of discovery in precision oncology? Fred Hutch is recruiting a Faculty Position, Bezos Family Distinguished Scholar in Precision Oncology within the Human Biology Division. Apply today: https://t.co/F8YpvZ3577

[Fred Hutch Cancer Center @fredhutch]

Scientists in the @HsiehLab at Fred Hutch Cancer Center found that the molecular regulator RNA—specifically tRNA, a type of RNA—may be able to influence the nature of prostate cancer cells and how they respond to treatment. Via @Newsweek https://t.co/ITulv4VYMs

[Hsieh Lab @HsiehLab]

@CarvalhoFilipeL @fredhutch @yeonsookim_phd @Nature Thanks @CarvalhoFilipeL!

[Hsieh Lab @HsiehLab]

Ever wonder if tRNAs can regulate the identity of a cancer cell?

@HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: https://t.co/V7FHTM0l5M

[Hani Goodarzi @genophoria]

What is fascinating about academia as a career is that there are certain ideas that you have been working on since you remember. The numerical optimalities of the genetic code is what drew me to biology in the first place. I ended up working on codon usage as grad student and tRNAs as a postdoc, as the language layer on top of the genetic code. And now, 25 years later, I’m still amazed by how under-explored this field remains.

So, new preprint with Vijay Ramani 🧵

[Hsieh Lab @HsiehLab]

@Dr_Di_Zhao @NimaSharifiMD @fredhutch @yeonsookim_phd @Nature Thanks @Dr_Di_Zhao!

[Hsieh Lab @HsiehLab]

@hansenhe7 @fredhutch @yeonsookim_phd @Nature Thanks @hansenhe7!

[Hsieh Lab @HsiehLab]

@genophoria @RuggeroDavide Thanks @genophoria!

[Hsieh Lab @HsiehLab]

@AnnaEnim @fredhutch @yeonsookim_phd @Nature Thanks @AnnaEnim!

[Hsieh Lab @HsiehLab]

@li_haolong @fredhutch @yeonsookim_phd @Nature Thanks @li_haolong!

[Hsieh Lab @HsiehLab]

@BullmanLab @fredhutch @yeonsookim_phd @Nature Thanks @BullmanLab! Unexpected indeed.

[Hsieh Lab @HsiehLab]

@Zhu_Lab @fredhutch @yeonsookim_phd @Nature Thanks @Zhu_Lab!

[Hsieh Lab @HsiehLab]

@DrOmarMian @LucasBSullivan @fredhutch @yeonsookim_phd @Nature Thanks @DrOmarMian!

[Hsieh Lab @HsiehLab]

@bloodgenes @fredhutch @yeonsookim_phd @Nature Thanks Vijay!

[Hsieh Lab @HsiehLab]

@NimaSharifiMD @DrOmarMian @fredhutch @yeonsookim_phd @Nature Thanks @NimaSharifiMD!

[Inside Precision Medicine @Inside_PM]

tRNA Influences If Prostate Cancer Becomes Resistant to Treatment

A single tRNA can influence whether prostate cancer cells mutate and become difficult to treat with standard therapies
@HsiehLab @fredhutch
#prostatecancer #tRNA #cancertreatment
https://t.co/pI2xk3U93Z

[Hsieh Lab @HsiehLab]

@KarunaMDPhD @CGFigE @fredhutch @yeonsookim_phd @Nature Thanks @KarunaMDPhD!

[Hsieh Lab @HsiehLab]

@srviswanathan @fredhutch @yeonsookim_phd @Nature Thanks Srini!

[Hsieh Lab @HsiehLab]

Thanks @RuggeroDavide!

[Davide Ruggero @RuggeroDavide]

Exciting new study from Andrew Hsieh @HsiehLab and team, revealing how a single tRNA can influence cancer cell identity, lineage plasticity, and therapeutic resistance. Another fascinating example of how the translation control specificity plays a much broader role in cancer!