Deepak Atri

Physician-Scientist | Former: @BrighamFellows @broadinstitute @OslerResidency @YaleMed @JohnsHopkins

[Varun Shanker @varunrshanker]

Excited to share our latest work in @ScienceMagazine. We describe how a structure-informed language model can be used for diverse protein engineering tasks, and guide the evolution of therapeutic antibodies for improved potency and resilience against viral escape.
https://t.co/tFN3FDrTT5
(1/n)

[Sanjay Desai @sanjayvdesai]

Best wishes to all the new interns across the country privileged to care for and learn from our patients. We are here to support you and so lucky to have you.

[Victor Nauffal @nauffal_victor]

Our work examining the biologic pathways underlying fibrosis in the heart now out @NatureGenet
Condensed summary: https://t.co/wT9WzjIhrd
Full article: https://t.co/kidKgiRsyu
@steven_lubitz @patrick_ellinor @broad_ml4h @broadinstitute @mghcvrc @bwhcvls
Main findings in 🧵👇

[Adam Butterworth @aidanbutty]

Great to see our work from the CARDIoGRAMplusC4D Consortium on the genetics of coronary artery disease finally out in Nature Genetics https://t.co/CpXaNAdpny

A short 🧵 to highlight some key findings..... 1/8

[DrJeffreyPF @DrJeffreyPF]

Happy & humbled to share our new manuscript out today in @CR_AACR . Great effort by all involved. The paper demonstrated that combined inhibition of NHEJ and MMEJ using two non-toxic, targeted DNA repair inhibitors can effectively induce toxic DNA damage to treat TP53-def cancers

[Vivian Lee @VS_LeeKim]

I am elated to share that I received the #NIHMOSAIC K99/R00 award! Much gratitude to my mentor Dr. Raj Gupta @Dr_RajatGupta, co-mentor Dr. Stephen Blacklow @BlacklowLab, and my Advisory Committee (@jengreitz, @mliarispe, @tmmichelangelo, Jonathan Seidman) for their support.

[Earth @earth]

A group of butterflies, otherwise known as a kaleidoscope, float through the trees.
cc: @hobopeeba

[Be A King @BerniceKing]

54 years ago today.

One week after my 5th birthday.

You were gone.

Assassinated for answering a call to conscience, for speaking truth to power, for being a drum major for justice who sought to rid the world of racism, militarism and poverty.

I miss you. Still. Always.

[Amazing Physics @amazing_physics]

Beautiful Colours of Chemistry. ❤💚💛🧡💗💜

[Eric Fauman (he/him) @Eric_Fauman]

While it is true that the gene closest to a GWAS peak is not always the causal gene, it is also true that it usually is.
In fact, we can quantify how often we should expect the causal gene to be the closest gene, and that number is about 70%
3 papers from 2021 help pin this down:

[Prof. Feynman @ProfFeynman]

Study hard what interests you the most in the most undisciplined, irreverent and original manner possible.

[Johns Hopkins Photography @JHHomewoodPhoto]

Today is a good reminder that @JohnsHopkins looks fantastic in any weather.

[Ardem Patapoutian @ardemp]

So many young people are hurting right now by rejections from colleges and graduate schools. I am still annoyed that the regional public university @csunorthridge rejected my transfer application from @AUB_Lebanon some 35 years ago. Thanks @UCLA for coming through. Stay strong!

[Deepak Atri @DeepakAtriMD]

@hyungjchun with another paper in a series of significant contributions to this evolving knowledge base.

[Eric Topol @EricTopol]

When Delta breakthrough hospitalizations occurred @YaleMed (mainly in people of advanced age and w/ comorbidities) the outcomes were better than unvaccinated with less deaths, shorter hospital stays
https://t.co/y47yGrkC7w @LancetMicrobe by @hyungjchun and colleagues

[Jodiene Johnson @JodieneJohnson]

A little Friday humor.

[Deepak Atri @DeepakAtriMD]

@myanamandala @bwhcvls @bmprii

[Deepak Atri @DeepakAtriMD]

Genome editing in primary human vascular cells can be a challenge. Check out our optimized protocol for CRISPR-Cas9 RNP editing in endothelial cells, VSMCs, and monocytes. 🧬✂️🫀
https://t.co/OYcn58jCGW
@Dr_RajatGupta @VS_LeeKim @kvshamz

[MIT CSAIL @MIT_CSAIL]

Alan Turing first defined what’s now the Turing Machine 84 years ago #otd, shaping how machines compute info. today: https://t.co/LnlSxHksAF

[Sanjay Desai @sanjayvdesai]

Thank you. Excited to meet and learn from everyone.