Demetriades Lab

The Demetriades Group @UMCG_ERIBA. We study Cell Growth and Nutrient Sensing via the TSC/mTOR network in health and in age-related diseases. Tweets by CD.

[Demetriades Lab @DemetriadesLab]

📢 I am so incredibly happy and proud about this one!
🔟+ years in the making, 2,5 years since first submission, 1⃣ year since we posted it @biorxivpreprint, it finally found it’s home @NatureCellBio!

Open access 👇
https://t.co/IWJTxkvmIv

Detailed 🧵down below ⏬

[Demetriades Lab @DemetriadesLab]

⚡️New @biorxivpreprint from our group⚡️
In this manuscript, we provide answers to the long-standing question "Where is mTOR and what is it doing there?", further complementing it with insights about "WHY is it there in the first place?"

https://t.co/qdOXALfSTK

Thread below👇

[Demetriades Lab @DemetriadesLab]

@emboreports @JNuchel Mechanistically, GRASP55 is required for the Golgi localization of the complete GOLPH3-LYSET-GNPTAB complex. In the absence of GRASP55, mislocalization of #LYSET and #GNPTAB is linked to their destabilization, in turn causing defective tagging and missorting of lysosomal enzymes.

[Demetriades Lab @DemetriadesLab]

💥 New publication from our group – final version now online in @emboreports!

Tour de force by Julian Nüchel (@JNuchel), with the amazing support from our collaborators and core facilities!

Read the full article here👇
https://t.co/LKPGBhU0sl

[Demetriades Lab @DemetriadesLab]

@emboreports @JNuchel GRASP55-deficient cells demonstrate lysosomal enzyme missorting (ending up into the extracellular space), #lysosome dysfunction and bloating, and perturbed lysosomal #mTORC1-TFEB/TFE3 signaling (while leaving non-lysosomal mTORC1 signaling intact).

[Demetriades Lab @DemetriadesLab]

🔗 Postdoctoral Researcher: https://t.co/fEqCs4DJir
🔗 PhD student: https://t.co/E9evHQzHJ1
(applications sent via email or social media will❗NOT❗ be taken into consideration)

Please spread the word 📢 and pass this on to potentially interested/suitable candidates!

[Demetriades Lab @DemetriadesLab]

💥 📢 We are recruiting! One postdoc 👨‍🔬👩‍🔬 and one PhD student 👨‍🎓👩‍🎓 position are now available in my new group 🔬 in ERIBA, part of the @umcg in Groningen.

Are you interested? Then send your application via the online platform, following the instructions in the links below 👇

[Demetriades Lab @DemetriadesLab]

@maxplanckpress @ERC_Research @AvHStiftung ps. Open positions for postdocs and PhDs to join us in Groningen will be posted here in the coming weeks – stay tuned.

[Demetriades Lab @DemetriadesLab]

With the turn of the year, an exciting new chapter has begun in my academic journey. I am beyond excited to share that I joined @UMCG_ERIBA in Groningen this month as a tenured Associate Professor.

[Demetriades Lab @DemetriadesLab]

I am also thankful to the Max Planck Society @maxplanckpress, @ERC_Research, DFG, @AvHStiftung, and all others who contributed, for their generous funding and continued support that made our work possible.

[Demetriades Lab @DemetriadesLab]

🎉👩‍🎓 Proudly celebrating the graduation of a new PhD from the @DemetriadesLab (#8 and last student to graduate from my @MPIAGE group)!
Huge congratulations, @JiyoungPan, on a truly remarkable PhD journey. A well-earned milestone! 👏

[Fusion Conferences @Fusion_Conf]

We are grateful to be surrounded by all these brilliant minds at #FusionAging25! Inspiring discussions, shared insights, and a commitment to advancing the future of aging. Here's to celebrating collaboration and progress at our Gala Dinner tomorrow evening!✨
#FusionAgingResearch

[Demetriades Lab @DemetriadesLab]

Looking forward to this amazing meeting already!

[The Company of Biologists @Co_Biologists]

Registration is now open for early-career researchers to apply for a funded place at our Workshop on Revisiting Metabolic Fundamentals, organised by @lydfinley& @WilhelmPalm. Find out more and apply at https://t.co/oBmoEsHATn
#BiologistsWorkshops

[Lydia Finley @lydfinley]

Applications are open for early-career researchers to attend our workshop on “Revisiting Metabolic Fundamentals” April 26-29, 2026 in East Sussex, UK. https://t.co/mavas5qtXz

[Fusion Conferences @Fusion_Conf]

This is your reminder there is only ✨2 WEEKS✨to go until our final registration deadline for #FusionAging25
📜Final Few Poster Slots Remaining!
🗓️Deadline: Thursday 07 Aug 2025
🔗Register here: https://t.co/fDNHBiblPJ

[Demetriades Lab @DemetriadesLab]

See you there n October! 🏰🇲🇹🏰

[Fusion Conferences @Fusion_Conf]

Did you know our Interventions in Aging series is turning 10 years old this year?🥳💜
Help us celebrate in Malta with the 5th edition this October - we look forward to seeing some familiar faces from the photos below, as well as meeting new ones! #FusionAging25 #FusionAgingResearch
🔗https://t.co/XpO2PpGNpo