Dr Denis Hartmann

Current Postdoc in the TAB-Lab at UoB. Former Oxford DPhil Student in the Booth group, Wolfson College, Bassoonist, Austrian, gamer, book-lover. he/him, 🏳️‍🌈

[Dr Denis Hartmann @DenisHartmann]

More of my postdoc work has now been published in @ChemEurope. This was a super fun project to work on, and with lots of diverse and challenging synthesis, characterisation, crystallography and DFT!

[UoBChemistry @UoBChemistry]

📰 The study of a homochiral perylene diimide dimer for sensing chiral anions is now out in @ChemEurope. Work led by Denis @DenisHartmann with contributions from previous MSci and MRes students Lucy and Jamie in the TAB-Lab @TabLabChem https://t.co/lrkjZtn977

[Angewandte Chemie @angew_chem]

A Bis-Perylene Diimide Macrocycle Chiroptical Switch (Timothy A. Barendt and co-workers) @DenisHartmann @TabLabChem @UoBChemistry @ZwijCompChem #openaccess 🔓 https://t.co/V9DbBrHpq6

[Dr Denis Hartmann @DenisHartmann]

My first major piece of postdoc work in @TabLabChem is finally out in @angew_chem. 🎉

[UoBChemistry @UoBChemistry]

A new chiral macrocycle which shows three-way switching of its chiroptical properties out now @angew_chem. Work by @DenisHartmann in @TabLabChem & fantastic collaborators @SamuelPenty and Robert Pal at @DurhamChemistry and @ZwijCompChem at @UCLChemistry https://t.co/Yw5eqZiSik

[RSC_MASC @RSC_MASC]

Starting off our second day with @DenisHartmann from @TABarendt talking about PDI macrocycles for molecular electronics and host-guest chemistry! #ECRMASC2024

[Dr Denis Hartmann @DenisHartmann]

My PhD work has made it into @SynCellEU 🥳

[Synthetic Cell initiative @SynCellEU]

@DrMikeBooth and his team at @UCLChemistry have developed a method to turn gene expression on or off using multiple wavelengths of light.
A promising technique to study complex cellular processes and advance #syntheticcell #research and #technology!
More:
https://t.co/yvD99iG4TT

[Dr Denis Hartmann @DenisHartmann]

@XiaoHaihua @J_A_C_S

[Dr Denis Hartmann @DenisHartmann]

Two of my PhD papers are now published back-to-back in @J_A_C_S! I really enjoyed working on those two projects, do go and give them a read 😁

[Michael Booth @DrMikeBooth]

Exciting 📢!

Our two @J_A_C_S articles have now been published back-to-back in the same issue 😍😍😍!

@DenisHartmann @Jack_Mazzotti @UCLChemistry @OxfordChemistry @OxfordSynthesis #DNA #ASO #synbio #cellfree #syntheiccell #photocage

[Dr Denis Hartmann @DenisHartmann]

And this is my last paper from my PhD published! 🎉

[Michael Booth @DrMikeBooth]

Another @J_A_C_S paper from the group!

We generated synthetic cells containing logic gates that can be *spatiotemporally patterned* with two orthogonal wavelengths of light!

Led by @DenisHartmann @JeffersonMSmith @Razia_C @OxfordChemistry @UCLChemistry https://t.co/leAJPRHq0I

[Michael Booth @DrMikeBooth]

We made *orthogonally* light-activated antisense oligonucleotides as precise switches for cell-free systems 🔦🧬

Published in @J_A_C_S 🤩!

Led by @Jack_Mazzotti @DenisHartmann @OxfordChemistry @OxfordSynthesis @UCLChemistry #DNA https://t.co/9r2kZytPoT

[Michael Booth @DrMikeBooth]

We've topologically constrained antisense oligonucleotides into a handcuff structure, via photocages, to control gene knockdown!

Published in @ChemCommun, led by @DenisHartmann
@OxfordChemistry @OxfordSynthesis @UCLChemistry #supramolecular #ASO https://t.co/s8T1JmKIIF

[Communications Chemistry @CommsChem]

.@DrMikeBooth, @DenisHartmann and co. report photocaged antisense oligonucleotides to knockdown cell-free protein synthesis using light. @UCLChemistry @OxfordChemistry @OxfordSynthesis @UCLChemLight https://t.co/zMdzZneXgM

[SBM CDT @OxfordSynthesis]

Great work by our very own @DenisHartmann out now in @CommsChem! https://t.co/BECarGRUnJ

[Michael Booth @DrMikeBooth]

We’ve developed light-activated antisense oligonucleotides by conjugating photocages to phosphorothioates 🤩🧬🔦!

Published in @CommsChem, led by @DenisHartmann @OxfordChemistry @OxfordSynthesis @UCLChemistry #ASO #DNA #light https://t.co/Ft96CAeBRB

[Michael Booth @DrMikeBooth]

@EPSRC We've got *2* EPSRC PhD opportunities to join our group in London to study the chemistry and application of nucleic acids, photocages, and polymers! 😍🧬🔦🌡️🧪
https://t.co/JcE4XGWf3O

[Dr Denis Hartmann @DenisHartmann]

One of my DPhil projects with @DrMikeBooth is now on chemRxiv! We developed light-activated antisense oligonucleotides by photocaging the backbone and could use that to control gene knockdown in cell-free expression! Have a look below!
@OxfordSynthesis @OxfordChemistry

[Michael Booth @DrMikeBooth]

We've developed light-activated antisense oligonucleotides by conjugating photocages onto phosphorothioates 😍🧬🔦!

We used these as cell-free expression OFF switches 🧪🛑⚡️!

Preprint from @DenisHartmann

@OxfordSynthesis @OxfordChemistry @UCLChemistry https://t.co/PKSYtFuphE

[Dr Denis Hartmann @DenisHartmann]

If you are curious what I spent a large part of my DPhil on so far, my project on blue light-activatable DNA is now available on ChemRXiv as a preprint! 🎉
@OxfordSynthesis @OxfordChemistry

[Michael Booth @DrMikeBooth]

We’ve developed blue light-activated DNA!

We used it to create the first dual light-activated cell-free logic gate 🤩🧬⚡️🧪

Preprint led by incredible student @DenisHartmann

@Razia_C @JeffersonMSmith @OxfordSynthesis @OxfordChemistry @UCLChemistry https://t.co/CsPiCYL9Fw

[Michael Booth @DrMikeBooth]

We’ve engineered light-activated communication between synthetic cells and living cells! 🧬⚡️🧫

Check out our preprint, led by my amazing student @JeffersonMSmith

@DenisHartmann @SynBioCDT @OxfordChemistry @UCLChemistry @SynCellEU @buildacell
https://t.co/sX0uSWxhUq

[Dr Denis Hartmann @DenisHartmann]

My poster is now up at the #Biochemistry2022 conference in Münster! Come have a look and chat to me (in 🇩🇪 or 🇬🇧) about blue-light controllable DNA, done under supervision of @DrMikeBooth as part of @OxfordSynthesis.
It is nice to have in person events again! 🎉

[Dr Denis Hartmann @DenisHartmann]

Preparing for a conference presentation with the smallest ironing board ever to iron the fabric poster 🎉

[Michael Booth @DrMikeBooth]

📢 4th Edition of @RoySocChem Nucleic Acids in Chemistry and Biology has now been released (Blackburn/Gait/Egli/@jwattsgroup) – The bible for scientists who work with nucleic acids

Furthermore, I wrote the revamped chapter on DNA and RNA Sequencing! 🥳
https://t.co/1HJFDZ0CU3