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Using skin as a clinically relevant model, Gabriel Batzli, Sarah Kleb, Drs. Stephenie Droll, and Brett Shook discuss how single-cell #RNASeqencing has advanced our understanding of mechanisms that regulate inflammation after injury.
π Read the review: https://t.co/YGRcdg5MCC
π¨ Researchers from @Westlake_Uni and @CAS__Science elucidate the coordinated spatiotemporal interplay of fibroblasts during #WoundRepair and spur novel therapeutic modalities and interventions for cutaneous healing.
Read more in @CellStemCell π https://t.co/DC7Ta1zT5t.
This study, led by co-first authors Jinmin Ye, Wenhao Li, and Yatong Qin, presents a dual-action microneedle therapy for #psoriasis that alleviates psoriasis by modulating #keratinocyte ferroptosis and scavenging cell-free DNA to restore inflammatory #homeostasis.
https://t.co/eHttbZvSBZ
π’ Researchers introduced a matrix metalloproteinase-9 (MMP-9)-responsive protein release system offering a precise, adaptive therapeutic strategy for #DiabeticFootUlcer. This system holds promise for other MMP-related diseases!
π https://t.co/UqJ55087mV
In @sigtrans_sttt, this review provides a systematic overview of the epidemiology, risk factors, diagnostic classifications, and comorbidities associated with acne.
#OpenAccess: https://t.co/XGVINSDP6r
Findings from a new study establish recombinant humanized type III #collagen as a structurally defined and reproducibly produced collagen-like #biomaterial with promising potential to support early repair of acute UV-induced #skin injury.
Congratulations to first authors Yi Xie and Yongjun Li of @iLZU1909, and their team!
Read the paper here: https://t.co/fZ46oIvuDp
Researchers from @CUHKofficial introduced an MMP-9-responsive protein release system as a precise, adaptive therapeutic strategy for #DiabeticFootUlcer. π£
Read the #OpenAccess article published in Advanced Science (@AdvPortfolio): https://t.co/UqJ55087mV
Though kallikrein 5 (KLK5) overactivation is known to contribute to several inflammatory skin disorders, research findings from @CincyChildrens demonstrate that complete loss of KLK5 is also pathogenic in atopic dermatitis-like responses in mice.
Read the #OpenAccess paper here: https://t.co/anLAevWoVf
#AD #AtopicDermatitis #Inflammation
This review highlights how #secretome-derived therapies offer a scientifically robust and clinically viable approach for restoring regenerative π± competence in aged skin.
Learn more: https://t.co/N7GQwMEE9l | #OpenAccess
Dr. J. Michelle Kahlenberg and investigators used cutaneous UVB photoexposure βοΈ of healthy controls and patients with #SystemicLupusErythematosus to provide an atlas of the cutaneous inflammatory response 24 hours after UV exposure in single-cell resolution.
π https://t.co/T9oxVQX9XJ
π New study published in @CellReports links enhancer co-occupancy by p63/p73 to signaling and tumor maintenance in skin #SquamousCellCarcinoma.
π Read the #OpenAccess article: https://t.co/5xsGCXydim.
Dr. Mariko Chikuma and researchers identified #TRPV4 β‘as an important mediator of #epidermal responses to low-humidity stress ποΈ , providing a molecular basis for low-humidity-driven signaling in the mammalian epidermis.
π https://t.co/dDC6F5Zgio
#OpenAccess
Researchers identified GLS1-mediated #glutaminolysis as a metabolic program preferentially induced in #keratinocytes under type 3 inflammatoryπ₯conditions.
Check it out: https://t.co/k5MAMGYGbZ
Researchers identified terminal epidermal differentiation-associated RNA as an important regulator of terminal #epidermal differentiation and suggest that its suppression may contribute to disturbed differentiation in inflammatory and neoplastic skin diseases.
πLearn more: https://t.co/iuGAvFA3UW #OpenAccess
Dr. Jiangang Feng and researchers including Xiaoyu Zhang suggested that the FOXQ1/SSBP2 regulatory axis plays a critical role in #melanoma progression and may serve as a potential therapeutic target π― to improve melanoma treatment outcomes.
π https://t.co/IRf8oXM2GU
#OpenAccess
New in @cddpress! β
Findings identify CaMK4 as a critical driver of pathogenic Th17 cell response via the STAT3/RORΞ³t axis in #psoriasis and suggest that it may represent a potential target π― for further therapeutic exploration.
https://t.co/rTTb6bErKG
A new study from Dr. Jiangang Feng's lab identified novel molecular targets associated with #melanoma progression.
π¦ Check out their work with FOXQ1 and SSBP2 in Molecular Carcinogenesis: https://t.co/rovvgcoJ0A
Scientists identified a previously unrecognized RNA-based mechanism that maintains pathogenic fibroblast states during #SkinFibrosis. @PNASNews
Check out their findings here:
π https://t.co/h52AobNikB