Dimpy Kalia

Utilizing the power of Organic Chemistry to address unsolved problems in Biology. Current interests: Protein Bioconjugation and cdiGMP signalling in bacteria

[IISER Bhopal @iiserbhopal]

We are delighted to share that a research article titled “Rapid and High-Yielding Disulfide Bioconjugation at Any Desired Site in Proteins” from the research group of Dr. Dimpy Kalia, Department of Chemistry has been published in the prestigious 𝙅𝙤𝙪𝙧𝙣𝙖𝙡 𝙤𝙛 𝙩𝙝𝙚 𝘼𝙢𝙚𝙧𝙞𝙘𝙖𝙣 𝘾𝙝𝙚𝙢𝙞𝙘𝙖𝙡 𝙎𝙤𝙘𝙞𝙚𝙩𝙮 (JACS).

The article describes the development of 𝗦𝘁𝗮𝗽𝗹𝗲𝗔𝗹𝗱 technology, a robust platform enabling stable, rapid, and quantitative disulfide bioconjugation of solvent-exposed cystine disulfides in proteins under physiological conditions. When combined with LAP tag technology (LAP-StapleAld), this chemistry becomes location-agnostic, allowing precise installation of lipoyl disulfide linkages at any desired site on a protein—opening new possibilities in chemical biology and protein engineering.

IISER Bhopal congratulates Dr. Dimpy Kalia and her research team on this outstanding achievement and wishes them continued excellence and many more high-impact scientific contributions.

🔗 Access the article via this link:
https://t.co/jA1c971oPV

@EduMinOfIndia @IndiaDST @DBTIndia @ANRFIndia @dasgobardhan @Dimpy_IISERB @chm_iiserb @J_A_C_S

#IISERBhopal #ResearchExcellence #JACS #ScientificAchievement #ProteinBioconjugation #ChemistryResearch

[Dimpy Kalia @Dimpy_IISERB]

@J_A_C_S @iiserbhopal @ANRFIndia @shivkuma_k @chm_iiserb

[Dimpy Kalia @Dimpy_IISERB]

Our latest paper is out in @J_A_C_S on disulfide bioconjugation on proteins (my first as a mother). This one is for you, little Timisa! Thanks @iiserbhopal @chem_iiserb @ANRFIndia @shivkuma_k for funding. #womeninstem #chemicalbiology #organicchemistry

[J. Am. Chem. Soc. @J_A_C_S]

Rapid and High-Yielding Disulfide Bioconjugation at Any Desired Site in Proteins | Journal of the American Chemical Society @iiserbhopal https://t.co/CaApsCRaxj

[IISER Bhopal @iiserbhopal]

We are delighted to share that Dr. Dimpy Kalia, from the Department of Chemistry, has been awarded the Thieme Chemistry Journals Award 2025. This prestigious recognition celebrates her significant contributions to the field of chemical research.

Adding to this achievement, Dr. Kalia’s lab has been awarded the MIT–IIT Kanpur Seed Fund Grant enabling her lab to join hands with Prof. Elizabeth M. Nolan’s group at MIT to investigate the unchartered pathways of bacterial signaling.

Congratulations to Dr. Kalia and her team on these outstanding accomplishments!

@iiserbhopal @dasgobardhan @EduMinOfIndia @IndiaDST @DBTIndia @serbonline @Dimpy_IISERB

[Dimpy Kalia @Dimpy_IISERB]

My lab has been awarded the MIT-IIT Kanpur Seed Fund grant @MISTIatMIT with Prof. Elizabeth Nolan's lab at @ChemistryMIT which will fund visits of personnel between the two labs enabling us to join forces to study bacterial signaling mechanisms using chemical biology approaches.

[Dimpy Kalia @Dimpy_IISERB]

Chemistry PhD interviews at IISER Bhopal have been announced. This time, there are several available positions in my group (https://t.co/cE3f0P5k6r) to pursue projects in synthetic organic chemistry, protein bioconjugation and chemical biology of bacterial signaling mechanisms.

[Dimpy Kalia @Dimpy_IISERB]

Humbled to be chosen as a Thieme Chemistry Journals Awardee 2025. Thanks to @thiemechemistry for the honour, and to @iiserbhopal , @chm_iiserb and @ANRFIndia for supporting my lab's research. https://t.co/9QYKv826cX

[Dimpy Kalia @Dimpy_IISERB]

Huge thanks to Dr. Ajay Kumar Srivastava, Dr. Kishor Mohanan, Dr. Namrata Rastogi, Dr. Anil Kumar K.S. and others for hosting such a great meeting.@chm_iiserb @iiserbhopal

[Dimpy Kalia @Dimpy_IISERB]

Honored to present at my alma mater @CSIR_CDRI and meet the person who shaped my career, my PhD advisor Dr. Dinesh Dikshit, and @batysan, Dr. Radha Rangarajan, Dr. Madhu Dikshit, @GautamPanda7, Dr. Amit Misra, Dr. Saman Habib, Dr. Koneni Sashidhara and others

[CSIR-CDRI @CSIR_CDRI]

🎓 CDRI Alumni Talks for the Next Generation!
✅ Dr. Dimpy Kalia (IISER Bhopal @iiserbhopal )
📖 Protein bioconjugation and the chemical biology of bacterial c-di-GMP signaling
Exploring new frontiers in chemical biology! 🔬 #CTDDR2025 #OurAlumniOurPride

[Dimpy Kalia @Dimpy_IISERB]

Back from an extremely enriching US visit. Presented talks at the Bioorganic Gordon Conference, @TuftsUniversity , and @ChemistryMIT. Huge thanks to GRC organizers @hargrovelab and @jbaryza, and @MattDShoulders and @Yu_Shan_Lin for hosting me at MIT and Tufts respectively.

[Dimpy Kalia @Dimpy_IISERB]

@DDasLab @NatureComms @serbonline @iiserkol Congratulations, Dibyendu! Nice work!

[Dimpy Kalia @Dimpy_IISERB]

@iiserbhopal @EduMinOfIndia @IndiaDST @serbonline @chemeng_iiserb @INYAS_INSA @paramitadas_drg Congratulations, Paramita!

[Dimpy Kalia @Dimpy_IISERB]

@MonikaRaj_lab @TheRajLab1 Congratulations, Monika!👍

[Dimpy Kalia @Dimpy_IISERB]

@ruchianand1975 @India_Alliance @serbonline @IndiaDST @DBTIndia @iitbombay Congratulations, Ruchi!

[Dimpy Kalia @Dimpy_IISERB]

Really humbled to receive praise from the great @kiranshaw for our lab's BHoPAL technology! Thank you very much ma'am for your kind words. Looking forward to employing BHoPAL for both pharmaceutical and basic research.@iiserbhopal @chm_iiserb @IndiaDST @serbonline #WomenInSTEM

[Kiran Mazumdar-Shaw @kiranshaw]

IISER Bhopal develops technology to link chemical tags to proteins for facilitating drug development, ET HealthWorld This is very impressive Kudos to Dimpy Kalia & her research team ⁦@iiserbhopal⁩ https://t.co/mchOxkZz5u

[Dimpy Kalia @Dimpy_IISERB]

@iiserbhopal https://t.co/G9aH6NOobE, https://t.co/rNBLwLoVeh

[Dimpy Kalia @Dimpy_IISERB]

Selected links of the media coverage of our recent paper. Thanks @iiserbhopal @chem_iiserb for the tremendous support at every stage from the start of the project 6 years ago right until the press release https://t.co/YRkQjOMinA, https://t.co/Fhl5LyYPqT, https://t.co/Ujd8eX8kya

[Dimpy Kalia @Dimpy_IISERB]

@iiserbhopal @chm_iiserb

[Dimpy Kalia @Dimpy_IISERB]

@NatureComms @iiserbhopal @chm_iiserb @serbonline @IndiaDST Thanks a lot everyone for your comments and reactions. I truly appreicate your support and encouragement!

[Dimpy Kalia @Dimpy_IISERB]

Unveiling our BHoPAL technology for quantitative location-agnostic site-specific protein labelling @NatureComms (https://t.co/12OKYKp04t) @iiserbhopal @chm_iiserb @serbonline @IndiaDST #organicchemistry #proteinbioconjugation #chemicalbiology #SERBPOWER #WomenInSTEM

[ACS Student chapter IISERB @iiserb_ACS]

Celebrating International Day of Women and Girls in Science !!! On this day, we are honoring the intellect, tenacity, and steadfast strength of women in science.
#InternationalDayForWomenInScience #ACS_Students_chapter #AmericanChemicalSociety