Disha K. Narang, M.D.| Endocrinologist, Dipl. ABOM

Obesity, and Culinary medicine doc. Trying to make the world healthier via weight management, habit change and food. Tweets are my own. IG: @dishanarangmd

[Michael Albert, MD @MichaelAlbertMD]

💡Can people with obesity reach a “normal” weight through diet & lifestyle alone?

A massive UK study of 177,000+ adults says… not easily.
📉 Over 9 years (no surgery involved):
For those with class 1 obesity (BMI 30–34.9):
🔹Men: 1 in 210 reached normal weight
🔹Women: 1 in 124
For severe obesity (BMI 40–44.9):
🔹Men: 1 in 1290
🔹Women: 1 in 677
⚖️ A 5% weight loss was more common (1 in 7–8/year) — but most regained it within 2–5 years.

🧠 Takeaway:
Community-based weight loss efforts often aren’t enough. We need better tools, access to effective treatments (meds & surgery), and bold public health action.
Source: https://t.co/Xe2534MlA1 #ObesityResearch #WeightLossJourney #PublicHealth
Adapted from @NeilFlochMD

[Michael Albert, MD @MichaelAlbertMD]

New research confirms the incredible weight management potential, cardiometabolic benefits, and safety of tirzepatide. Future incretins need to attempt a similar imbalanced agonism of GLP1/GIP. This gets me excited for SURPASS-CVOT & SURMOUNT-MMO!
https://t.co/ZhaG4wW40f

[Angela Fitch,MD @DrAngelaFitch]

Thank you @EliLillyandCo for innovation on care delivery by providing access to the vial program. Now at a lower price (would have liked lower but 🙏 for a future of lower yet) and more dosing options!

https://t.co/zptqHB3vUP

[Neil Stone @DrNeilStone]

Because of conventional medicine

-Your mother didn't die in childbirth
-You didn't get polio as a kid
-You've never seen smallpox
-Your friend with type 1 diabetes is alive because of of insulin
-You recovered from that infection because of antibiotics

Science saves lives

[Michael Weintraub, MD @MWeintraubMD]

Higher Body Mass Index is strongly linked to less sleep.

Data from objective sleep monitoring with wearables from 120K individuals.

Study link: https://t.co/1QGuoEA2ug

[Scott Isaacs @scottisaacsmd]

Treatment with #tirzepatide in the SUMMIT trial led to a lower risk of death from cardiovascular causes or worsening heart failure and improved health status in patients with #HFpEF and obesity.
https://t.co/O9iU9a1Xgw

[Mark Lewis, MD, FASCO @marklewismd]

There is a wisdom from the lived experience of patients that is not found in any medical textbook but that they teach to us in practice

“Running, walking, and crawling are all moving forward, just at different speeds”

[Daniel J Drucker @DanielJDrucker]

The FLOW trial was stopped early due to clear benefits for using semaglutide to reduce progression of kidney disease and cardiovascular death in people with #T2D at risk for progressive diabetic kidney disease @US_FDA @novonordiskus

[Disha K. Narang, M.D.| Endocrinologist, Dipl. ABOM @DishaKumarMD]

@HeartOTXHeartMD You will be sorely missed!

[Michael Weintraub, MD @MWeintraubMD]

There is a move toward revising the definition of obesity away from BMI and more toward better measurements of excess fat, based on this week's Lancet Commission.

We can evaluate someone's level of excess fat by body through measuring someone's waist circumference or waist-to-height ratio.

How does one appropriately measure waist circumference or waist-to-height ratio? 🤔

Check out a video by the NHS from the UK on how to properly make this measurements:
https://t.co/QUk1pBOV4c

[Michael Weintraub, MD @MWeintraubMD]

Obesity can be under or over-diagnosed when BMI alone as a criteria is used.

Instead, measuring for excess body fat and evaluating for obesity-related diseases is a more accurate method of diagnosing obesity.

See the new Definition and Diagnostic Criteria of Clinical Obesity commission statement, published in Lancet today: https://t.co/FqoMNYs4hJ

[Nisha Patel, MD MS, Dipl of ABOM, CCMS @DrPlantel]

Woohoo! Medicare has approved Zepbound for the treatment of sleep apnea (OSA)! THIS IS HUGE! Hopefully commercial insurances will soon follow.

Let this be a reminder to people that GLP-1 medications are not just “weight loss” meds. They are cardiometabolic medications with more & more data demonstrating significant improvement in multiple health outcomes.

[Disha K. Narang, M.D.| Endocrinologist, Dipl. ABOM @DishaKumarMD]

@chrissyfarr Happy birthday Chrissy!!

[Michael Weintraub, MD @MWeintraubMD]

Both GLP1-RA and SGLT2 inhibitors reduce cardiovascular events in people with Type 2 Diabetes.

But does combination GLP1-RA + SGLT2 inhibitors reduce CV events more than GLP1-RA alone?

Yes, according to a recent meta-analysis.

In adults with type 2 diabetes, those adding empagliflozin to GLP1-RA had lower risks of MI, stroke, HHF, and all-cause mortality compared to those adding SU to GLP1-RA.

MACE reduction HR 0.75
Heart Failure hospitalizations HR 0.54

https://t.co/ii7S4DFzf0

[Daniel J Drucker @DanielJDrucker]

Label expansion as @US_FDA approves the GIP-GLP-1 medicine tirzepatide for moderate to severe obstructive sleep apnea https://t.co/nEligtX61I $LLY @EliLillyandCo

[Ethan J. Weiss @ethanjweiss]

The unique thing about GLP1RAs is that these drugs are not going away despite whatever hysteria is drummed up by skeptics . Unlike most drugs (eg, statins), people desperately want them, not because they will reduce the risk of serious chronic disease (they will)

[Michael Weintraub, MD @MWeintraubMD]

🚫 Why is aspirin 💊 not recommended for primary prevention in Type 2 diabetes?

15,480 adults with T2DM were randomized to aspirin 100mg had significantly lower rates of cardiovascular events 🫀 by 12% vs those on placebo.

Why don't we give aspirin to everyone with T2DM? 🤔

Because aspirin also significantly increased major bleeding events🩸.

So benefits did not outweigh the risks ⚖️

A more personalized approach is possible if we can better identify those with increased platelet activity.

NEJM Ascend trial: https://t.co/Cy0PxOeXDd

[Scott Isaacs @scottisaacsmd]

Semaglutide is an option for treating obesity in patients with kidney failure on dialysis. This could significantly aid in their weight loss efforts and improve their chances of being listed for kidney transplantation. #semaglutide
https://t.co/10hB8IjwO2