Happy to share our work showing that the NRF2 activating compounds, DMF and 4-OI, induce the secretion of the anti-inflammatory protein Annexin A1 from macrophages! @DiskinCiana@EscherToller@laoneill111
https://t.co/2Euk7eUFQ3
Very happy to share that our paper is out in @NatureComms! It was a long and exciting journey to find out more about the role of PKM2 in neutrophil functions! A huge thanks to all collaborators, specially @laoneill111, and to my supervisor @JC_Alves_Filho. https://t.co/kEu4Hg34wU
Huge congrats to @laoneill111 and co-first authors @AlexHooftman, @ChristianGPeace and @metab_innate 🥳 A massive achievement that is so well deserved, you guys made a fantastic team ⭐️
Our paper is out today in Nature linking Fumarate Hydratase to inflammation.
Big thanks to all our collaborators and congrats to Alex Hooftman @AlexHooftman Christian Peace @ChristianPeace and Dylan Ryan @metab_innate for their great ideas and hard work.
https://t.co/j9NZeKzAjR
Great representation from the @laoneill111 lab at the poster session at #MHD22 with @DiskinCiana presenting her work on indole-3-pyruvate and @ChristianGPeace showcasing our work on fumarate hydratase 👏🏼
Huge congratulations to Marah from our lab with the latest on the itaconate story @Cell_Metabolism : "Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages"
Very impressive work!! 🥳
https://t.co/Q30usG473R
Couldn’t have our usual lab Kris Kringle this year so (right to left) Shane, Lucas, Tristram and Alex left mine outside my house with a cocktail and distributed to others too. Took a quick snap from the front door. Kathy helped too. Well done on the logistics!
check out our news page! Scientists discover new ways to block inflammatory cells implicated in a suite of diseases https://t.co/YL904MZJ39 @laoneill111@DiskinCiana
Our paper and long overdue final chapter of my PhD is now online. Huge congrats to the incredible @DiskinCiana who has a second first author paper in the same edition! @laoneill111
https://t.co/HCbfcgneDD
Secondly, we have my original PhD project where we show that two derivatives of Krebs cycle metabolites, 4-octyl itaconate and dimethyl fumarate, decrease expression of COX2 and thereby suppress prostaglandin secretion by macrophages @laoneill111
https://t.co/nuxyt23Y0x
Seems that papers are like buses, with two coming along at once! First is a project started during @sarahcorcor's PhD and finished during mine. We show that a trypanosome metabolite directly inhibits COX2 activity to limit prostaglandins @laoneill111
https://t.co/KzNS8ewWNe
Our new review from the @laoneill111 lab, Targeting immunometabolism to treat COVID19, is out now in @IMTadvances . This review details potential immunometabolic modulators to combat the hyperinflation seen in COVID19.
https://t.co/5DvKDJHgPZ
Excited to see our News & Views finally out for @NatureCellBio! Me and @AlexHooftman discuss one of the mechanisms for SARS-CoV-2 immune evasion. 🧪🔬Many thanks to @laoneill111 Lab.
Have a look at it here: https://t.co/GjzXureRsq