Navindra Soodoo, Ph.D.

PhD Materials Chemist | Biomaterials & Small Molecules | Decoding the Chemistry of Drugs & Supplements | How They're Built, Why They Work, What's Myth

[Navindra Soodoo, Ph.D. @DrSoodooLab]

https://t.co/x0vOcj3GbN

[Navindra Soodoo, Ph.D. @DrSoodooLab]

"Only fish oil lowers triglycerides."
"Lower one lipid, fix them all."

What the chemistry says:

Peony + danshen extract, 12 weeks: triglycerides 207 to 175 mg/dL. Placebo rose to 208.

Artery thickness didn't budge.

J Functional Foods
https://t.co/BO1pDT20L1

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@KatiStowe @SamaHoole That sounds like a tough road. Stomach acid can rebound after long-term use, which is why any change is best planned with your doctor. Wishing you some relief.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@KrittanawongMD Exactly. Outcome trials tell us what happens, and the pharmacokinetics help explain why it holds up. Thanks for the thoughtful reply.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@KrittanawongMD Well said. Serial changes tell the story far better than a single value, and that distinction matters most in MINOCA. Appreciate you sharing the clinical side.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@BowTiedPhys Oxygen is the underrated part. Fibroblasts need it, plus vitamin C, to hydroxylate proline so collagen strands can lock into a stable triple helix. Better blood flow from lifting delivers more of exactly that.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@BowTiedPhys Choline does double duty: it's the raw material for acetylcholine, a key memory neurotransmitter, and for the phosphatidylcholine in every cell membrane. One yolk carries about 150 mg, much of it already in phospholipid form.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@Boldstocksbabe KCL-286 is a nice piece of medicinal chemistry. It's a small molecule that selectively switches on retinoic acid receptor beta, one of the receptors vitamin A's active form uses, which helps sidestep the baggage of broad retinoid drugs.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@Outdoctrination Human milk oligosaccharides are a clever pick. Our own enzymes can't break these complex sugars, so they reach the colon intact, where Bifidobacteria ferment them into short-chain fatty acids that feed the gut lining.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@KenDBerryMD DIAAS is the right lens. Collagen, a common bar filler, contains no tryptophan at all, so its DIAAS is essentially zero even though every gram counts toward the protein number on the label. Eggs have no such gap.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@KenDBerryMD The beta-glucan catch is chain length. Its cholesterol effect depends on long chains that make gut contents thick and viscous. Extrusion and puffing can chop those chains, so a gram in a cereal may not act like a gram in steel-cut oats.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@SamaHoole The fuel chemistry here is elegant. BHB becomes acetyl-CoA in just two enzyme steps inside the mitochondria, bypassing glycolysis and pyruvate dehydrogenase entirely, the very stages that seem to struggle in these brains.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@SamaHoole Rapeseed oil says it all. Old rapeseed was high in erucic acid, so Canadian breeders reworked it into low-erucic canola in the 1970s. The star fat of that "ancient" diet is younger than most people reading this.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@LeddyLLC Cartilage has no blood vessels, so it feeds by being squeezed. Each stride presses fluid out and lets nutrient-rich fluid soak back into its water-loving proteins. Gradual, regular loading is part of how knees stay healthy.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@nicknorwitz Context changes the chemistry. With carbs very low, insulin stays low, so saturated fats like palmitate get burned for fuel instead of stored, and the liver makes far less palmitate of its own. Same 23%, very different metabolic fate.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

Some reactions are slow. That doesn't mean they're failing.

Give your work time, the right conditions, and keep showing up. The yield comes.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@PeggyMaca @SamaHoole She sounds remarkable. Cooking for officers and keeping a family healthy without doctors takes real know-how. That kind of kitchen wisdom often got the chemistry right long before science explained it.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@eddieroberts @drjamesdinic Great question. Materials chemistry is really about how structure drives function, and collagen is a perfect example: a triple helix held together by glycine and hydroxyproline. Same lens, just applied to the body.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@KrittanawongMD Exactly right. Lower detection limits catch smaller injuries, but they also flag troponin rises from causes beyond MI, so interpretation becomes the real skill. Thanks for adding that.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@KenDBerryMD Neat way to see it: HbA1c is literally glucose stuck to hemoglobin. The sugar binds the protein and rearranges into a stable bond, and since red cells live about 3 months, the number reflects months of eating, not one good week.

[Navindra Soodoo, Ph.D. @DrSoodooLab]

@FitAndFortune Solid list. Creatine's trick is simple chemistry: phosphocreatine hands its phosphate back to ADP in a split second, rebuilding ATP during short, hard efforts. Monohydrate is still the best-studied form, so fancy salts rarely add much.