Ethan Seltzer

PhD Candidate in the Tavazoie Lab @ Rockefeller University

[Rockefeller University @RockefellerUniv]

Good luck to Rockefeller's Clare Cahir, Heloise Carion, Erika Layfield, Julia Losner, @daniel_s_oh, @ESeltzr, Taylor Wallace, and all other runners in the NYC Marathon this Sunday! 🏃🏽 🏃🏽‍♀️ 🏃🏽‍♂️

[Blavatnik Awards @BlavatnikAwards]

Did you know that breast #tumors hijack sensory nerves to drive #cancer #metastasis? 2025 Blavatnik Regional Laureate🥇@VeenaPadmanaban @RockefellerUniv has discovered this crosstalk mechanism between them to identify new #breastcancer therapeutic targets https://t.co/W8gFcEAlv0

[Sohail Tavazoie @SohailTavazoie]

🚨Women with ER(–) breast cancer who took aprepitant (anti-nausea drug, NK1R blocker) had a 31% lower risk of metastasis or death (p<0.001) in large Norwegian study by Botteri & Chang. More doses = better survival 📉.Clinically validates our work by @VeenaPadmanaban: neuronal substance P drives BrCA metastasis via tumor NK1R & is blocked by aprepitant. https://t.co/lvxmFxA3g8. @RockefellerUniv @theNCI

[Elvina Almuradova @Dr_ElvinaA]

Can aprepitant improve outcomes in TNBC?
In a cohort of 13,811 women, aprepitant use during chemo linked to:
📉34% ↓ distant recurrence (HR 0.66)
📉39% ↓ breast cancer mortality (HR 0.61)
👉 Especially in triple-negative breast cancer

🤔 Could this be due to better treatment continuation via improved tolerability?
Or is there a molecular mechanism—e.g., NK1R pathway involvement?

https://t.co/OaICDuNtv7

@OncLive @OncoAlert
@SuyogCancer @Larvol

[Waggoner Lab @LabWaggoner]

Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses @jclinicalinvest @TheresaLuLab
https://t.co/khcLE0FMwu

[Wenbin Mei @wenbin_mei]

EXCITED to share my PhD work in @CellCellPress. We found that the chance of developing metastasis is partly decided by the DNA we inherited. We identified a germline variant in PCSK9 present in 70% of the white women conferring higher risk of breast cancer metastasis. (1/9)

[Rockefeller University @RockefellerUniv]

Good luck to Rockefeller's Marina Caskey (@marinacaskey1), Julia Losner, Brian Oh, Ethan Seltzer (@ESeltzr), Taylor Wallace, Mahsa Shirani Faradonbeh, and all other runners in the @nycmarathon this Sunday! 🏃🏽 🏃🏽‍♀️ 🏃🏽‍♂️

[Ethan Seltzer @ESeltzr]

Had an amazing time at the NIH this week sharing and learning about the great research being done by my fellow junior investigators! #NCIJI2024

[ImmunoSketch @ImmunoSketch]

Imagine nerves as highways that help cancer cells spread, but a common anti-nausea drug can act like a roadblock to slow this down.

https://t.co/gRPrDxbKgB

@VeenaPadmanaban @SohailTavazoie @IsabelKel @ESeltzr @benostendorf

[nature @Nature]

Nature research paper: Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis https://t.co/Sfl5WxRuLb

[nature @Nature]

The sorts of nerve that allow people to touch, see, hear and taste can help breast cancer cells to infiltrate other regions of the body https://t.co/I5XBJpPIHZ

[Rockefeller University @RockefellerUniv]

Researchers in @SohailTavazoie's lab found a “neuro-cancer axis” that may promote the spread of breast cancer. They also found that an FDA-approved anti-nausea medication may prevent it: https://t.co/vjnTds0yQy #RockefellerScience

[Ethan Seltzer @ESeltzr]

Our paper in @Nature is out! We demonstrate that sensory neurons drive breast cancer metastasis via paracrine signaling mediated by substance-P. Fortunate to work with such a great team lead by @SohailTavazoie and @VeenaPadmanaban with support from @IsabelKel @benostendorf &amp; more

[Veena Padmanaban @VeenaPadmanaban]

🚨❗️🚨 New Paper Alert
My postdoctoral work now out in @Nature. We find that sensory neurons drive breast cancer metastasis via an activity-dependent paracrine signalling mechanism mediated by substance-P, extracellular ssRNA &amp; TLR7 receptor. (1/11)
https://t.co/0eDdmLubGT$
🧵👇🏾

[Ethan Seltzer @ESeltzr]

Grateful for the opportunity to contribute to this work with @thomasmlii and many amazing collaborators!

[Theresa Lu Lab @TheresaLuLab]

It's out! Our story shows that IFN inhibits Langerhans cell ADAM17 in photosensitivity and is a resource for transcriptomic profiles of non-lesional skin from 3 lupus models. Congratulations to Thomas, Victoria, Ethan and coauthors!
https://t.co/35wXgCvpdN

[Cell Reports @CellReports]

Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load https://t.co/NEyoMAJB7C

[Ethan Seltzer @ESeltzr]

Congratulations to my amazing colleague and friend @thomasmlii!

[UCSF Surgery @UCSFSurgery]

‼️We're thrilled to introduce the 8⃣ talented individuals who have matched into our @UCSFGSResidency as General Surgery Preliminary Interns - We're delighted to offer a heartfelt and eager welcome to each of you as you commence this enriching journey with us! #Match2024 🎉🥳

[biohub @biohub]

We’re thrilled to share that we’re launching a new @CZBiohub in New York!

Bringing together engineers + scientists at @Columbia, @RockefellerUniv and @Yale, #CZBiohubNY will engineer immune cells for earlier detection &amp; treatment of disease

[Thomas M. Li @thomasmlii]

New preprint from @TheresaLuLab assessing the role of interferon acting on Langerhans cell ADAM17 in lupus photosensitivity! Thank you to all authors and collaborators involved for bringing this project to life: https://t.co/Y9KmE4b0C4 @VictoriaZyulina @ESeltzr @HSpecialSurgery

[Tim Stearns @StearnsLab]

A better title for this article would be “Huge demand for PhD scientists leads many to land high-paying jobs in the biotech sector” https://t.co/RffVV8Y7XG

[NTV Kenya @ntvkenya]

BREAKING: Eliud Kipchoge breaks his own world record to win Berlin Marathon
#BerlinMarathon2022