Eachan Johnson

Group leader @TheCrick | antimicrobials 🧪 chemical genetics 🧬 sys bio 🧫 Opinions are my own. he/him

[Eachan Johnson @EachanJohnson]

Taking a hiatus from updates here, but more - including open positions in the SCBIR lab @TheCrick - over there 👉 https://t.co/VJ5UWUyhJs

[Louise Walport @lwalport]

Now out in print: https://t.co/ohMMteC276

See Maria's thread below for a nice summary of what we got up to and let us know if you'd be interested in trying out any of our new tools for probing the function of PAD4/PADI4

[Biochemical Journal @Biochem_Journal]

Check out this #OA review article, where Parkhill and @EachanJohnson explore potential routes to discover new antibacterial drugs, highlighting various classes of antibiotics, such as glycopeptides. #AMR #Microbiology #DrugDiscovery
https://t.co/Dpnfw5wvRz

[Louise Walport @lwalport]

I'm delighted to share our recent article developing an approach to identify cyclic peptide binders of challenging protein targets directly in cell lysates - led by @catherine_hurd with GSK's @Jake_T_Bush and Andy Powell @TheCrick @impch

[David Balchin @balchin_david]

New from our lab @TheCrick , led by @BetkaRoe. A fun side project that tried to understand what happens when a chaperonin encounters a translating ribosome.
https://t.co/2t0cpKIMKl

[Rashmi Priya @rashmi-priya.bsky.social @_Priya_R]

...and if you find this work exciting, we have fully-funded PhD/post-doc positions available @TheCrick! International, collaborative environment, terrific Science and plenty of training & career support at every stage. Do get in touch, more details here 
https://t.co/iXHDZOUVnI

[Biochemical Journal @Biochem_Journal]

Check out this #OA review article, where Parkhill and @EachanJohnson explore potential routes to discover new antibacterial drugs, highlighting various classes of antibiotics, such as glycopeptides. #AMR #Microbiology #DrugDiscovery https://t.co/Dpnfw5wvRz

[Rashmi Priya @rashmi-priya.bsky.social @_Priya_R]

Beyond thrilled to present our first (!) work @TheCrick! A tour de force by @tobyandrews et al combining imaging, solid morphometrics, theory, perturbations to show how a developing heart grows and scales up its morphological complexity to keep beating...
https://t.co/RghtQtmYxF

[Prof Miraz Rahman @MirazRahman]

Discovery of new antimicrobial has been neglected by UKRI for a while. Probably the panels still think almost non-existent Pharmaceutical research programmes will deliver new antibiotics. Very short sighted.

[Eachan Johnson @EachanJohnson]

Using lots of illustrative examples, we advocate using molecular genetics in harmony with phenotypic drug discovery. Let us know what you think!

https://t.co/R8C0cn2LNK

[Eachan Johnson @EachanJohnson]

Our review on the past, present, and future of antibacterial drug discovery is out in @Biochem_Journal! It's the result of hard graft by Susie Parkhill, an excellent 3rd-year PhD. We aimed to be (hopefully) readable, informative, & a little provocative 🧵 https://t.co/R8C0cn2LNK

[Eachan Johnson @EachanJohnson]

Resistance mechanisms can act on chemical structure of drugs or compensate for their biological action. So we need more integrated approaches that understand both the biology and the chemistry of new drugs. We can't focus only on vulnerable targets 🧬 or only on safe chemistry 🧪