Jacob Bush

Chemical biologist at GSK and the Francis Crick Institute.

[Jacob Bush @Jake_T_Bush]

@PracticalFrag @angew_chem @GSK @HarryWilders

[Practical_Fragments @PracticalFrag]

Synthesis without purification still yields clear fragment hits.  'Direct-to-Biology' screens crude reaction mixtures & yields covalent and noncovalent inhibitors of SARS-CoV-2 main protease
https://t.co/lToSmtSlI3
@angew_chem @Jake_T_Bush @GSK

[George Biggs @georgebiggs94]

Excited to share a key part of my postdoctoral work from @TheCrick and @GSK , published in @NatureComms . A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems.

https://t.co/16gsEjFLNF

[Jacob Bush @Jake_T_Bush]

Rapid optimisation of covalent and non-covalent SARS MPro inhibitors by ‘direct-to-biology’ reactive fragment screening. Great work by Harry Wilders on @ChemRxiv from @GSK, @UniStrathclyde and @TheCrick. #chembio https://t.co/Xbzz61ZBcE

[Louise Walport @lwalport]

I'm delighted to share our recent article developing an approach to identify cyclic peptide binders of challenging protein targets directly in cell lysates - led by @catherine_hurd with GSK's @Jake_T_Bush and Andy Powell @TheCrick @impch

[Jacob Bush @Jake_T_Bush]

Fantastic work by George, Emma and the team in the @GSK and @TheCrick collaboration: a robust chemoproteomics platform to screen covalent compounds against the proteome. Exciting work on-going to deploy at scale with AI/ML to map the druggable proteome. https://t.co/HNYuP1qRvN

[Adam Matthew Thomas @AdamMThomasChem]

Hot off the press! Check out our ‘mutate and conjugate’ paper in @ACSBioMed 🔥
Here we demonstrate that combining site-directed mutagenesis and reactive fragments can be used to rapidly identify selective covalent probes for target validation studies.

[Stuart Conway @conway_group]

Our 'Mutate and Conjugate' paper is out now in ACS Chem Biol (@ACSBioMed)! We combine site-directed mutagenesis and electrophilic fragments to identify inhibitors the mutant protein with a view to helping target validation.
https://t.co/hN0oOHupVy
#chembiol #medchem

[Nathaniel Jones @DrNathJones]

Happy to share our latest preprint. Catherine used #biochemical & #structural methods to study the #epigenetic reader protein BDF5 as a potential drug target in #Leishmania. Partnership between @Mottram_group , Wilkinson lab @YSBL_York & @conway_group. https://t.co/lbdcb3cq8P

[RSC Medicinal Chemistry @rsc_medchem]

Check out recent work by @Jake_T_Bush, Nicholas Tomkinson & co:

'Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry'

The #OpenAccess article is online now🔓

https://t.co/BXE4p4AvgH

📍 @GSK and @UniStrathclyde

[Jacob Bush @Jake_T_Bush]

Excited to share the latest publication from our collaboration between @GSK and @TheCrick. Expanding the liganded DUBome to support target validation in biomedical research. Great work from Rosa Cookson, Aini Vuorinen and co-authors. #chembio @target2035 https://t.co/VA0ilBM8XP

[Burley Research Group @BurleyResearch]

Our latest paper in collaboration with @GSK describes how the reactivity of a series of SuFEx reagents influences covalent modificaiton of the proteome. Congratulations to @KateGilbert_ , @Jake_T_Bush and @arronaatkar .
https://t.co/R1aoL66Yy4

[Covalent Modifiers @CovalentMod]

Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments [@arronaatkar] https://t.co/yhkaCfc21N

[Jacob Bush @Jake_T_Bush]

Check out @arronaatkar’s work taking reactive fragments into new landscapes: beyond-cysteine covalent ligand discovery with sulfonyl fluorides @ChemRxiv. Great collab @GSK, @StrathChem, @TheCrick. #chemicalbiology #covalentmodifiers
(Artwork @emma_k_grant)
https://t.co/Tay2C2Jmie

[Jacob Bush @Jake_T_Bush]

Excited to share this opportunity for a bioinformatics post doc in the Crick-GSK collaboration https://t.co/aPBeffmNHr

[Jacob Bush @Jake_T_Bush]

Great opportunity to join the @TheCrick / @GSK partnership to build systems chemical biology approaches to therapeutic discovery. #chemicalbiology #chembio #covalentmodifiers

[J. Mark Skehel @SkehelJM]

We're recruiting for the Crick/GSK EPSRC prosperity partnership! If you're thinking about a postdoctoral position have a look at the link below! @TheCrick

https://t.co/mRnLpa9Zcv

[J. Mark Skehel @SkehelJM]

We're recruiting for the Crick/GSK EPSRC prosperity partnership! If you're thinking about a postdoctoral position have a look at the link below! @TheCrick

https://t.co/mRnLpa9Zcv

[RSC Medicinal Chemistry @rsc_medchem]

Register now for our free #RSCDesktopSeminar Lectureship webinar, featuring Lectureship winners @Jake_T_Bush & @london_lab!

📅 4 Aug 2022 at 1 PM BST

Even if you can't attend on the day, be sure to register to receive a recording of the webinar later!

https://t.co/rR4D8BIKd7

[RSC Medicinal Chemistry @rsc_medchem]

Our #RSCDesktopSeminar Lectureship is TODAY! 🎉

Register now to see talks by our Lectureship winners, Dr Jacob Bush (@Jake_T_Bush) and Dr Nir London (@london_lab) at 1 PM BST ➡
https://t.co/rR4D8C0lBH

[RSC Medicinal Chemistry @rsc_medchem]

One week until our free #RSCDesktopSeminar Lectureship webinar, featuring our 2021 & 2022 winners, Dr Jacob Bush (@Jake_T_Bush) and Dr Nir London (@london_lab)! ✨

📅 4 August 2022 at 1 PM BST
🔗 https://t.co/k8k4DVdiyW