Ed O'Brien, MD FRCPC

Cardiologist / CSO Pemi31 Therapeutics / Advancing “ICAST” immune therapy to lower inflammation and cholesterol levels for coronary artery and liver diseases

[JoAnne Foody, MD, FACC, FAHA @FoodyMD]

Special request from @DrMarthaGulati! Adding CLEAR outcomes to the “line of parity”in a shareable slide! First nonstatin outcome trial since to have 50% women. Lean in ♥️♥️♥️@EsperionInc @Drlipid @CMichaelGibson @ErinMichos @DBelardoMD @PeterAttiaMD @Drroxmehran

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Pemi31 Therapeutics is now seeking investment for the final stage of pre-clinical development and the launching of its pre-IND phase for its therapeutic platform targeting lipid lowering and prevention of NASH. (Attached: latest published US patent for PC…https://t.co/2EkiTzaRc1

[NewAmsterdam Pharma Corporation @NewAmsPharma]

@ProfKausikRay, a member of our clinical advisory board, shared data from our ROSE study in his #ACC22 session describing How to Go Lower. The data show obicetrapib, our oral #CETP inhibitor, is effective at lowering LDL-c in combination with high-intensity statin therapy.

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Pemi31 Therapeutics advances its IP Portfolio aimed at lowering PCSK9 and treating atherosclerosis and NASH via a first in class mechanism that increases LDLR expression. The HSP27 immune complex is a platform technology (called ICAST for Immune Complex A…https://t.co/VdWGrfpCmi

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

@benhibbertMDPhD @NEJM @adnanalkhouli @Babar_Basir @seanvandiepen @BillONeillMD @DrCindyGrines @dzavik_vlad @ebelleycote @NavinKapur4 @SrihariNaiduMD @CombesProf Huge congrats on this impressive study. Recruiting 192 with cardio genie shock patients is very challenging and the results are important in guiding future therapeutic strategies. Well done!

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

The new "one-two punch" to prevent atherogenesis: HSP27 Immunotherapy lowers cholesterol AND inflammation.

Novel mechanism for upregulated LDL-R expression, lowering of PCSK9 and reduction in systemic, plaque and hepatic inflammatory biomarkers.

Now i…https://t.co/pJkyzQ7QnI

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Now more than ever is the time to invest in Public Health!

[StrategyCorp @StrategyCorp]

NEW PODCAST – You can also listen to Dr. Michelle Gagnon talk about her paper’s recommendations for how Canada can learn and improve its public health on Intended Consequences now!

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Great to see @CaladriusBio continue to show important progress developing therapies for coronary micro vascular dysfunction, an increasingly recognized cause of angina in women - particularly post-menopause

[Lisata Therapeutics, Inc. @lisata_tx]

Stories like these emphasize the dire need for therapies treating cardiovascular diseases, particularly in women, like our CD34+ cell therapy, CLBS16, for the treatment of coronary microvascular dysfunction.
https://t.co/iePZzMZJQT @HeartSisters @EdOBrien_HSP27 @DrMarthaGulati

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Can you get cholesterol out of atherosclerotic arteries ... and reduce plaque inflammation? Previously we showed that Heat Shock Protein 27 (HSP27) could do both via reverse cholesterol transport. Our latest study shows that one method by which HSP27 prom…https://t.co/q2YRqTBkQb

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Why are women relatively protected against COVID-19? HSP27, a potential new estrogen related therapy for hyper-inflammation (https://t.co/OgnCFvbs1j)

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Twice as many men as women die of COVID-19. Why? It is possible that female hormones, like estrogens, may be protective against the ravages of the SARS-CoV-2 viral infection.

Heat Shock Protein 27 (HSP27) is an estrogen-responsiv…https://t.co/faKhEvuZlE https://t.co/11lZ7EgFAk

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Inflammation plays a critical role in atherogenesis and plaque instability. While Heat Shock Protein 27 (HSP27) lowers cholesterol, it also dampens inflammation - dual modality "athero-protection". See the latest review paper from…https://t.co/XA4OZYJsnJ https://t.co/8qlk5PnJXg

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

The loss of a giant in vascular biology - an atypical mentor and an incomparable mind - we will all miss his impetuous but brilliant questions that seemed to come from left field, but were always right on target. He trained many but inspired many more, his legacy will live on.

[UW Medicine Newsroom @uwmnewsroom]

Dr. Stephen Schwartz, 78, a longtime professor of pathology @UWMedicine @uwpathology is remembered for his pioneering work in vascular biology, for mentoring generations of scientists, & for his vigorous advocacy for research & scholarly endeavors https://t.co/MLRx1AKOpB

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

@lucykellaway Very irresponsible!

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Heart and Stroke Foundation of Canada Heart Month 2020 Spotlight on Women
@HeartandStroke @LibinInstitute #RedList #KVsax #CV&Me https://t.co/a8tzwchIgY

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Libin International Trainee Symposium: Research is Better with Sex and Gender! Feb 4-5, 2020 https://t.co/0pdpIF9Vr6

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Sad to learn of the passing of a great scientist and collaborator. Although we focused on different diseases - she was always quick to share common biological insights. Obituary: Professor Jackie de Belleroche PhD, DS 1945-2019 | Imperial College London https://t.co/rEtjPyrF7V

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Luckily @cityofcalgary warmed up yesterday for CUPS Xmas in January 2020! Over 250 guests, @calstampeders and Mayor @nenshi! Congratulations to @CarleneDonnelly and her @CUPSCalgaryAB staff, volunteers. Thanks to the @HyattCalgary for the delicious meal!

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Catch What the @HeartandStroke Foundation of Canada is saying about our Women's Heart Health research aimed at developing novel vaccination therapies for Post-menopausal Coronary Artery Disease https://t.co/2Mc0rf3E1i

[Ed O'Brien, MD FRCPC @EdOBrien_HSP27]

Catch What the Heart & Stroke Foundation of Canada is saying about our Women's Heart Health research aimed at developing novel vaccination therapies for Post-menopausal Coronary Artery Disease https://t.co/mbKBIvcvP8