Very pleased to share our latest work, led by @ExelbyKR and myself, supervised by @psollich and @briscoejames.
There's plenty of fun for all: Enhancer KO, stochastic modelling, tissue patterning, non-eq statistical mechanics, and much more!
https://t.co/Bviv0p7Yp2
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Our article "The Clock and Wavefront Self-Organizing model recreates the dynamics of mouse somitogenesis in vivo and in vitro" is out in @Dev_journal 🥳 Discover how the Sevilletor equation can self-organize to make somitogenesis waves! #SelfOrganization
https://t.co/8aRDx4pRne
Our updated study of how SOX2 levels direct the WNT response of embryonic progenitors is now out! https://t.co/lgGBYgcZia
It was quite a puzzle to unpick – hopefully this thread helps to show why we found it so intriguing.
🧑🔬Behind every great image, there are great scientists. Let us showcase the cameramen & camerawomen from
@cellworlds_off
➡️ @maitrejl@oozguc@MSchliffka@Edge_HD and others from @institut_curie@CNRS
🔍Look for them : https://t.co/hpYKS1Wbsr
Do you have a background in physics, mathematics or computer science and want to move to Spain☀️? If your are excited about self-organization and non-equilibrium thermodynamics apply for this scholarship to join our lab. Deadline 27-01-2022, more info here https://t.co/In5sLf34qP
Happy to see this piece out, we have covered (to our knowledge) all theoretical approaches to understanding preimplantation development. We discuss how modelling has provided concrete insights to the field, and look forward to exciting advances ahead! @maitrejl@CellsDev
Theoretical modelling can be very helpful, sometimes essential, to understand the mechanisms controlling embryonic development. Here is a brief overview and perspective on modelling preimplantation development with @Edge_HD@CellsDev
https://t.co/1cOZmm3q5E
Our latest: Quantifying Waddington Landscapes
* Constructed dynamical models of ES cell differentiation from data
* Identified 2 fundamentally distinct mechanisms of binary decisions
* Models make quantitative predictions & generally applicable
https://t.co/ToucMz0NRi
Interested in understanding how the amazing diversity of neurons in the nervous system emerges during development? 1 week left to apply for a PhD position in the lab of @SagnerAndreas at @UniFAU! https://t.co/RweNSkWXjF
There's apparently a sweet spot for explanation. A senior PI at a famous department said to me once: "the 1st part of your talk, showing the amazing things bioelectricity does in the body - I loved it! But then you showed the mechanism, turns out it's just physics :-(" 1/n
Cleavage stages: 2 days without much going on, as far as morphogenesis is concerned. Cells must be pretty quiet, right? Well, actually it depends on how fast you're imaging! Here is the latest preprint from the lab with @oozguc!
https://t.co/BHYD8Ihwd5
New preprint!
As a synthetic dev biologist, I always wanted to manipulate the shape of organoids. We developed an optogenetic tool to induce apical constriction in mammalian cells. Illumination of neural organoids caused shrinkage of the apical lumen. 1/
https://t.co/F0JgPdidf8
We are thrilled that our paper with the Schwille lab is now online in Nature Physics https://t.co/Kn7Zea4YAK. Below is a brief summary of this joint experimental and theoretical work by the two first authors @BeatriceRamm and @AndriyGoychuk 👇
Our latest: Quantifying Waddington’s landscape
Theory & xpts to construct dynamical models of differentiation:
- makes testable quantitative predictions
- reveals two fundamental cell decision mechanisms
- generally applicable to wide range of systems
https://t.co/uP17L8LKp2
New on the Node - Precision by design: Setting boundaries in patterning
@Edge_HD looks back on a theoretical-experimental collaboration that gave insights into the robustness of neural tube patterning
#BehindThePaper#DevBio
https://t.co/i0Sf0SZnB7