The number from AGBT 2026 that changes everything for AI x Biology: $0.06 per million reads — ~10× cheaper than leading platforms.
The math for Perturb-seq at ~20K reads/cell:
1B cells × 20K reads × $0.06/Mreads = ~$1.2M
Billion-cell perturbation datasets just went from out of reach for most teams to economically plannable.
But cheaper reads ≠ better models. The bottleneck shifts to experiment design: which perturbations, which cell types, which contexts. A billion cells of random data is wasteful. A billion cells of the RIGHT data — that's the hard problem.
The limiting factor in computational biology is no longer the cost of measuring cells. It's the wisdom of choosing what to measure.
Meet the real rainbow fish 🌈🐟 Using Cre-mediated recombination, each zebrafish cell expresses a unique fluorescent color, creating a living rainbow of developmental history 🎨✨ Image by Bret Pearson #FluorescenceFriday#Zebrafish#DevBio
Our paper identifying evidence of off-target probe binding in the 10x Genomics Xenium Breast Gene Panel is now available as a reviewed preprint at #eLife
https://t.co/dQ9FqTMCdY
We look forward to revising the paper to incorporate reviewer recommendations and other updates 🧵👇
New paper from the lab with @andrewlutas. Work of the amazing Claire Gao. Important read exploring mechanistic insights as to why semaglutide may work better for some versus others. Building on all the amazing research that has been done over the years. https://t.co/afXbbZOjpr
📣 Hiring, please forward widely!!
Two postdoc openings to work on genomics of diabetes
1. computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@CRGenomica
https://t.co/4LjyznQWCk
https://t.co/BY8b6Obd5o
Congrats to Victor and Gary!! Victor is profoundly beloved here at @UMassChan , he always has the most interesting questions and ideas and is 100% kind all the time - a truly brilliant and generous spirit. He lifts up our entire community! Very well-deserved.
UMass Chan Medical School researcher Victor R. Ambros, PhD, arrives on the @UMassChan campus with his wife, Rosalind "Candy" Lee, after learning he is sharing the 2024 @NobelPrize in Physiology or Medicine. WATCH news conference at 10 a.m. EST: https://t.co/KC66QUHQrW #NobelPrize
Need to combine BED files into a consensus set? Our paper with methods to do this just came out in NAR! --Methods for constructing and evaluating consensus genomic interval sets https://t.co/IXCZvXNaIz
Our amazing lab manager is moving onto different opportunities and we're looking for a new lab manager/technician to join our dynamic and diverse team at UCalgary. See the link for details. Please RT.
https://t.co/fRjYKJ1ORZ
Happy to share my recent Current Opinion in Cell Biology @ELS_CellBiology
What is liver zonation? How do hepatocytes organize their activities in the tissue? And what does cell-cell communication and gradients have to do with it?
https://t.co/aEpeoratZp