New work from Xueyi and team: Chem-CLIP-Map, a method to map small molecule binding sites on RNA using nanopore sequencing and fragment analyzer.
https://t.co/07XCr0UHkx
#RNA#ChemCLIP#DrugDiscovery
Updated preprint:
Cell growth rate strongly impacts the mechanisms controlling variation in protein concentrations.
We report larger than previously appreciated role of protein degradation to protein variation, both across proteoforms & tissue types.
https://t.co/5XG8M3B4b8
New paper out in Biochemistry!
We lay out a roadmap for targeting human RNAs with small molecules—focusing on genetically validated targets, functional binding sites, and cellular activity.
A step toward unlocking RNA’s drug potential.
https://t.co/0Th1VtKnZ5
#RNA#DrugDiscovery
New preprint: The first whole-body map of both DNA methylation and 3D genome organization at single-cell resolution across 16 human tissues, with in-depth analyses of cell type diversity of these epigenome modalities at unprecedented resolutions. (1/5)