Mikhail Eltsov

DNA and chromatin in situ/ Cryo-ET @IGBMC

[Mikhail Eltsov @EltsovMikhail]

We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ

https://t.co/lRrk3SvF8y

[Mikhail Eltsov @EltsovMikhail]

@kazu_maeshima @ScienceAdvances @MasaAShimazoe @rcollepardo @janhuemar Congratulations Kazu!

[Mikhail Eltsov @EltsovMikhail]

I am not afraid to say it: this is the most fundamental advance in our understanding of chromatin structure since the zig-zag fiber model.

[Kazuhiro Maeshima @kazu_maeshima]

Using single-H1 imaging and computational modeling, we show that most H1 behaves like a liquid inside chromatin domains, rather than binding stably to nucleosomes as in the textbook model.
Congrats, @MasaAShimazoe & all contributors! 🎉 2/2
🔗https://t.co/fGZsmvRPWK

[Mikhail Eltsov @EltsovMikhail]

@Miguel_Montez_ Thank you!

[Mikhail Eltsov @EltsovMikhail]

We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ

https://t.co/lRrk3SvF8y

[Mikhail Eltsov @EltsovMikhail]

Generate crowded synthetic tomographic data and train your model for particle picking in real data.
Impressive work by Mohamad Harastani:
https://t.co/vq5iaAJIhr

[Mikhail Eltsov @EltsovMikhail]

@kazu_maeshima @biorxiv @shiori_iida @MasaAShimazoe Congratulations, Kazu! Fascinating work. This study provides solid evidence for the old ideas of Jacques Dubochet and Andy Belmont.

[Kazuhiro Maeshima @kazu_maeshima]

Our new work @biorxivpreprint
🔗https://t.co/rpWHc1Br9k
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates.
@semeigazin @katsu_s_minami @MasaAShimazoe

[Benoit Zuber @ben808080]

A plain language overview of our recent publication

https://t.co/KFYydcl93j

[bioRxiv Biophysics @biorxiv_biophys]

Straightening FSC curves https://t.co/x85nkOB0Uw #biorxiv_biophys

[Mikhail Eltsov @EltsovMikhail]

@ben808080 Congratulations!

[Benoit Zuber @ben808080]

Our latest paper is out. Getting high resolution reconstruction from vitreous cryo-sections.

[Svetlana Dodonova @Sveta_Dodonova]

the first preprint of the lab! So excited! 😎#archaea #cryoEM #chromatin #Asgard

[Kazuhiro Maeshima @kazu_maeshima]

I am seeking an Assistant Professor in my lab. If you are interested, please contact me! 📩
ゲノムダイナミクス研究室で助教を公募中です。ご興味のある方はぜひご連絡ください！
RTお願いします。 🔄
日本語版👇👇👇

[Kazuhiro Maeshima @kazu_maeshima]

🧬My retrospective chromatin review is out@Proc Jpn Acad: https://t.co/0te20pvDUj
Textbook models of 30-nm fibers are fading. A new paradigm: chromatin forms liquid-like domains—locally dynamic, yet globally stable at chromosome level (viscoelastic)—supporting genome function.✨

[Kazuhiro Maeshima @kazu_maeshima]

🎥 Video: See chromatin in action — each dot is a single nucleosome, dynamically fluctuating in a living HeLa cell (TMR-labeled, 50 ms/frame).
Original paper: https://t.co/ZLzM5qSDEt

[Mikhail Eltsov @EltsovMikhail]

A question for the experts: Can you recognize nucleosomes and linker DNA in this data?
Find an updated version of our manuscript in
https://t.co/54OnoU7qaC

[Mikhail Eltsov @EltsovMikhail]

@kazu_maeshima @MasaAShimazoe @rcollepardo @janhuemar Congratulations Kazu! H1 binding has been always a key question of chromatin. Beautiful work!

[Mikhail Eltsov @EltsovMikhail]

@kazu_maeshima @NatureComms Congratulations, Kazu!

[Mikhail Eltsov @EltsovMikhail]

Spectacular work!

[Kazuhiro Maeshima @kazu_maeshima]

Excited to share our new paper @NatureComms.
https://t.co/RsRQ5F02Bt
Single-nucleosome imaging reveals that condensins act as molecular crosslinkers, locally constraining nucleosomes to organize mitotic chromosomes. Nucleosome-nucleosome interactions constrain whole chromosomes.

[Florian Fäßler @FaesslerFlorian]

There is still time to apply for the cellular structural biology #postdoc position in my team @IGBMC. This is your opportunity to acquire/further hone your cryo-ET skills ❄️