Using single-H1 imaging and computational modeling, we show that most H1 behaves like a liquid inside chromatin domains, rather than binding stably to nucleosomes as in the textbook model.
Congrats, @MasaAShimazoe & all contributors! 🎉 2/2
🔗https://t.co/fGZsmvRPWK
Generate crowded synthetic tomographic data and train your model for particle picking in real data.
Impressive work by Mohamad Harastani:
https://t.co/vq5iaAJIhr
I am seeking an Assistant Professor in my lab. If you are interested, please contact me! 📩
ゲノムダイナミクス研究室で助教を公募中です。ご興味のある方はぜひご連絡ください!
RTお願いします。 🔄
日本語版👇👇👇
🧬My retrospective chromatin review is out@Proc Jpn Acad: https://t.co/0te20pvDUj
Textbook models of 30-nm fibers are fading. A new paradigm: chromatin forms liquid-like domains—locally dynamic, yet globally stable at chromosome level (viscoelastic)—supporting genome function.✨
🎥 Video: See chromatin in action — each dot is a single nucleosome, dynamically fluctuating in a living HeLa cell (TMR-labeled, 50 ms/frame).
Original paper: https://t.co/ZLzM5qSDEt
A question for the experts: Can you recognize nucleosomes and linker DNA in this data?
Find an updated version of our manuscript in
https://t.co/54OnoU7qaC
Excited to share our new paper @NatureComms.
https://t.co/RsRQ5F02Bt
Single-nucleosome imaging reveals that condensins act as molecular crosslinkers, locally constraining nucleosomes to organize mitotic chromosomes. Nucleosome-nucleosome interactions constrain whole chromosomes.
There is still time to apply for the cellular structural biology #postdoc position in my team @IGBMC. This is your opportunity to acquire/further hone your cryo-ET skills ❄️