Epigenomic Mechanisms in Human Disease

Epigenomics Research Group: Christopher G Bell - Barts & The London; QMUL

[Epigenomic Mechanisms in Human Disease @EpigenomicMed]

-expressed genes. It highlights the fascinating, intertwined nature of developmental and ageing-related pathways.
Thanks to @impetusgrants @hevolution_f [2/2]
#CpG #ucCpGs #epigenomics #DNAmethylation #ageing #aging #populationgenetics @QMULepigenetics
https://t.co/5BVqtM54Bg

[Epigenomic Mechanisms in Human Disease @EpigenomicMed]

BioRxiv preprint from us identifying ultra-conserved Human CpG Dinucleotides - the crucial motif for DNA methylation in differentiated cells - from >0.5 million whole genome sequences (UKB/gnomAD).
This identified enriched signals in developmental, ageing and brain... [1/2]

[Epigenomic Mechanisms in Human Disease @EpigenomicMed]

Quantifying stochasticity in the ageing DNA methylome - comment on the 3 recent @NatureAging papers
https://t.co/TzSZEfvPtF
Viewable link here - https://t.co/NUT3o1uRHc
@qmulepigenetics
#epigenetics #DNAmethylation #ageing #aging

[Nature Aging @NatureAging]

📎Now see the associated News & Views from Christopher Bell, covering all three studies @EpigenomicMed https://t.co/XiwjB8wl6u https://t.co/JF4QG4aihl

[@qmulepigenetics @QMULepigenetics]

Great review article on "Epigenomic insights into common human disease pathology" by Chris Bell from QMUL Centre for Epigenetics
https://t.co/A2gfnvv00T

[Epigenomic Mechanisms in Human Disease @EpigenomicMed]

https://t.co/Nwve89t494
#epigenomics #commondisease

[Miguel Branco @BrancoLab]

We have two new faculty opportunities at QMUL, part of a £3.2M investment by @Barts_Charity to develop genomic and epigenomic liquid biopsy analyses for diagnostics and research applications.
More details here: https://t.co/TBlDEp1sF0
Please RT abundantly

[Barts Charity @Barts_Charity]

Early and accurate diagnosis saves lives.

With our funding, teams @QMUL @blizard_inst and @nhsbartshealth will investigate how the marks on our DNA unlock vital genetic information to diagnose a much wider range of diseases than ever before.

[Genome Centre @BartsLondonGene]

Great to be involved in this work, just in the press.

A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain https://t.co/bDhUiL6gK7

@blizard_inst @QMUL @QMULBartsTheLon @QMULWHRI @QMUL_LSI @QMBCI

[GenomeWeb @GenomeWeb]

Hundreds of Hypertension-Related Effector Genes Identified in Genetic Fine-Mapping Study. Investigators used genetic fine mapping and multiomics to identify 436 blood pressure-related candidate effector genes, some of which could become drug targets.  https://t.co/7HHgPXudpr

[William Harvey Research Institute @QMULWHRI]

Scientists from @QMUL @OfficialUoM @unizar @UniofOxford reveal the genetic underpinnings of blood pressure regulation, offering hope for more effective treatments and preventative measures for hypertension. https://t.co/lk0QGjXWlP
@ManchesterBRC @BartsBRC @AJHGNews @NIHRresearch

[Gabi Ficz @GabriellaFicz]

📢 New publication from our lab spearheaded by @Emilysaun, a truly collaborative work with Bonnet lab (Crick) @DrHHEncabo and Marion Piganeau, @EpigenomicMed @JulieDevis J. Gribben and @kevin_rouault https://t.co/PCXhUr2OPr This story aims to disentangle cause and consequence..🧵

[Epigenomic Mechanisms in Human Disease @EpigenomicMed]

Interviewed in National Geographic about the AI-driven assessment of ‘biological’ age - through facial & other modalities - and ageing-related diseases
https://t.co/uUGcGGODgr
#ageing #chronicdisease
@QMULepigenetics @QMULWHRI @DERI_QMUL
@QMULBartsTheLon

[@qmulepigenetics @QMULepigenetics]

Don't miss this exciting #postdocjobs to join Chris Bell's lab in London @qmulepigenetics, @QMULWHRI in #epigenomics #Ageing – exploring the functional impact of the DNA methylome in ageing/ageing-related disease. Funded by @impetusgrants apply here https://t.co/FGzqaUqBxR

[Julia Ramírez @Ju_Ra_Ga]

📢In our latest preprint we prioritise 394 consolidated effector genes for hypertension🩸by integrating fine-mapping and multi-omics 🧬
https://t.co/dP0G3V5MsL

[Epigenomic Mechanisms in Human Disease @EpigenomicMed]

We have a post-doctoral position available in epigenomics & ageing – exploring the functional impact of the DNA methylome in ageing/ageing-related disease. Funded by @impetusgrants
https://t.co/iz40SoXVQ3
@QMULWHRI @qmulepigenetics #epigenomics #ageing

[nature @Nature]

Nature research paper: A DNA methylation atlas of normal human cell types https://t.co/NA4rSbtkfj

[@qmulepigenetics @QMULepigenetics]

Please join us for @qmulepigenetics event at @blizard_inst for the focused meeting on "DNA-on-repeat" (in person only) on 14th Dec 2022. We will have talks, posters, X-mas jumper competition & drinks. Pl submit abstracts for talks & posters, details 👇
https://t.co/pCttgGCjOs

[ASHG @GeneticsSociety]

Live from LA, it's #ASHG22 ☀️

We are so excited to welcome you back in person for five days of breakthrough science!

➡️ https://t.co/bjnxvLdHY1

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”