Eyo

Elucidating the role of microglia in acute brain injuries, neurovascular function and sex differences in development, maturity and disease

[Eyo @eyolab]

7 years ago, at my PhD Graduation, my Advisor gave me this picture of my last days in grad school grading papers, father-ing and finishing up my Thesis. His point was that Grad school had successfully built into me some level of multi-tasking that would be vital for success 🤓😎

[Eyo @eyolab]

Results here are promising to suggest continued focus on Trem2 activation in AD. They show rescued cognitive and synaptic phenotype with just 2 weeks of Trem2 activation. Would be nice to interrogate other AD models and older ages. Exciting nonetheless 🙏🏾
https://t.co/Bc971OrbCb

[Eyo @eyolab]

@Andy_P_Tsai @NIH @wysscoray @BrunetLab @StephenQuake @Stanford @IUStark_Neuro Fantastic news, Andy!!!!

[Eyo @eyolab]

Exciting findings that could "re-write" two decades of dogma that microglia are not replaced by infiltrated monocytes. Or perhaps humans experience recurring pathologies that elicit monocytes replacement of microglia. 🤯. does it happen in mice as well? https://t.co/bhaANMpFGA

[Eyo @eyolab]

@harris_kaplan @UVA Welcome @harris_kaplan!!!

[Eyo @eyolab]

Notably comprehensive work identifying cMAF as a transcription factor specifying perivascular macrophages and facilitating its regulation of CSF flow and hypercapnic arterial blood flow. 👍🏾https://t.co/QTnHgBGji7

[Tré Mills @astrecyte]

Hi all, I am going on the job market, and I have made a website containing important information and documents. You can find that here: https://t.co/mjdTqo8ZVo

Please pass along to anyone who is hiring. Thank you!

[Eyo @eyolab]

Fascinating new findings suggesting through epigenetic assessments that human microglia are replaced by infiltrating monocytes in aging challenging the notion that yolk-sac derived microglia are maintained without infiltration throughout (human) life. 🤯https://t.co/XXUHGtKKe1

[Eyo @eyolab]

Fifteen years after microglia were first implicated in synaptic pruning, this new study now implicates B cells originating from the skull bone marrow in synaptic pruning. So much for the "immune privileged" brain 😉 Cool findings from @soyonhonglab's group https://t.co/6qMwFXRcTY

[Eyo @eyolab]

This guy is killin’ it: T32, postdoc fellowship; Career Development Award; Nature Communications papers; now K99 and he’s on the job market. Most importantly a great person, scientist, and colleague. Huge congratulations @astrecyte 🎉🤩👏🏾

[Tré Mills @astrecyte]

I'd like to announce 1) that I have received my K99/R00 award entitled, "The role of microglia-pericyte signaling in maintaining basal capillary tone in health and Alzheimer's Disease" and 2) I am on the job market.

[Eyo @eyolab]

The MicroglEyo Lab turns 8 today🥳. We've trained 9 postdocs, 5 grad students, 6 staff members from 9 countries and 5 continents; we've published 38 papers, 15 grants and given 104 seminars/talks. We've received much help from so many to build this foundation for the next 8😉🤩!

[Eyo @eyolab]

Our latest study showing novel sex differences in
· astrocyte density and synaptogenic factor expression;
· excitatory synapse density &
· neuronal activity
through hormone-regulated microglial MerTK-dependent microglial phagocytic action in the developing somatosensory ctx🤩

[Cell Reports @CellReports]

Sex differences in somatosensory circuitry are programmed by developmental microglia-astrocyte interaction https://t.co/oLaPPCPry8

[Eyo @eyolab]

@bimald Congrats on the funding achievement but this is so sad.

[Eyo @eyolab]

The picture is how it started; this story is where we are at: https://t.co/HFz3Or3NZN. Beautiful story on (newly minted) Dr. Kareem El-Ghazawi from the @PeirceLab through whom @PeirceShayn and I jointly mentored! Always delightful to see successful individuals 🤩.

[Eyo @eyolab]

@jonykipnis lol

[Eyo @eyolab]

@PottorfTana @SfNJournals Congrats, Tana!!!

[Eyo @eyolab]

@PottorfTana @AAUW @OSUNeuroscience @OSUWexMed @McPopLab_OSU Congratulations!!!!!!!!

[Eyo @eyolab]

Brain Institute Pic'23 winner✅
@UVAimmunology Day'24 Poster winner✅ Universidad Central de Venezuela🇻🇪graduate✅
@UVA🇺🇸PhD recipient✅
Canadian🇨🇦Postdoc next✅
International scientist;microglial P2RY12 guru✅
Introducing Dr.Aida Lopez-Ortiz @neuroarroz https://t.co/Ip2SY6tUBG

[Eyo @eyolab]

Excited to be speaking at the joint Keystone Symposia on Neurodegeneration: From Neurocentric to System-Wide Perspectives / Neuroinflammation in Health and Disease, Whistler, British Columbia, Canada. Looking forward to great discussions!
Register here: https://t.co/wy4hoUpvhr

[Eyo @eyolab]

@jonykipnis Jony, this is really nicely put! I like the second point especially (putting "life" and "work" in conflict). It gave language to some of my concerns. I have recently been modifying the term to "work-life integration". The actionable focus of point one is also golden. 👌Olga!

[Eyo @eyolab]

NIH MARC Fellow ✅
NIH RISE Fellow✅
NIH T32 Fellow✅
Published academic author✅
Published popular science article author✅
HHMI Gilliam Scholar✅
Awesome *former* grad student✅
Current US Patent Officer✅
Introducing Dr. Synphane Gibbs-Shelton💪🏾