Brunet Lab

Aging lab @Stanford - Epigenomics and metabolism in #aging; Brain aging and rejuvenation; Neural stem cells; C. elegans; African #killifish

[Loïc A. Royer 💻🔬⚗️ @loicaroyer]

Want to build some of the most advanced light-sheet microscopes in the world to watch life assemble itself cell by cell?

The Royer Lab @ Biohub is hiring an Optical Engineer (Advanced Light Sheet Microscopy).

🔬🔧 #Hardware + #Python + Advanced #Optics

https://t.co/LLoHqTiBEy

[Polly Fordyce @fordycelab]

Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)

[Itamar Harel @ItamarHarel]

A 🧵
When DNA damage repair (DDR) fails, it activates the innate immune sensor cGAS. But does this sensor actively exacerbate the disease?

Our new paper reveals a dual role for cGAS in shaping both cellular and organismal responses to genomic instability: https://t.co/rkyHfyK8dh

[Karl Deisseroth @KarlDeisseroth]

Directional elements: the preprints are out! Congratulations to our amazing team linked here:
https://t.co/SxNw2isNcd
https://t.co/f48w42FKcJ
https://t.co/o5NXdGcViw
We screened for principles governing global brain dynamics by developing a set of new methods: 1) conformal immersion microscopy for recording high-speed/high-resolution neural activity across dorsal cortex; 2) unbiased computational screening of brain-spanning activity for fast directionally-propagating spatiotemporal elements; and 3) novel genetically-encoded voltage sensing integrated with designed spectrally-compatible opsins (derived from our channelrhodopsin structure work) for systematic causal testing.
This unbiased screening/testing approach (which we show is applicable either to voltage or calcium imaging) allowed discovery and functional validation of a surprisingly well-defined set of directional elements that generalized across cell types and frequencies. The ability to work over long timescales at high speeds and with broad scope, anchored in optogenetic causal testing, unveiled rich spatiotemporal structure that was remarkably tractable.
From the perspective of natural brain function, the directional elements were found to be behaviorally relevant and robust to diverse perturbations; however, we also found specific conditions allowing elemental incidence and boundaries to be selectively modulated, which may provide translational as well as basic-science insight...
I'm so grateful to all our collaborators, and honored to work with all the outstanding students, postdocs, and staff who worked together to develop and apply this approach...

[Nalini Rao @NaliniRRao]

Excited to share my first postdoc work co-led with Yuichi Chayama, from @andcyang lab - now out in @CellCellPress! We created a genetic system to trace how the brain clears waste, uncovering surprising new biology about waste clearance pathways. 🧵1/9

🔗 https://t.co/1s7AcXZcv4

[Inigo Martincorena @imartincorena]

Our autoimmunity paper is now OA in final form. We found a fascinating landscape of somatic evolution underpinning thyroid autoimmunity, where tens of B cell clones convergently lose immune checkpoints and some acquire 4-6 drivers over years of evolution. https://t.co/KrHKhXA4QS

[Katherine Aird @airdlab]

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats @ApoorvaUboveja!
https://t.co/o4ekqG9E4Y

[Yael David @Yael_David__]

Going outside of our chromatin comfort zone here, the brilliant @YangXiao_TPCB discovered that SRSF2 undergoes non-enzymatic glycation that disrupts its function & leads to the missplicing observed in cancer! Great collab w/ @CalebLareau & @AbdelWahablab

https://t.co/zllCcwbdfH

[Michael Snyder, PhD @SnyderShot]

Our consortium paper on deep profiling of individuals of different ethnicities located across continents just came out. I HPP initiative involving many different labs from aorund the world and an amazing open access resource. Full of cool results. https://t.co/zJgWCCS0bQ

[Irene Miguel-Aliaga @FlyGutLab]

The beautiful PhD work of our postdoc @elisa_delaunoit is out! https://t.co/y1XSI5MbcH

[Kim Tolias @kft70]

Happy to share that I've joined Stanford as Professor in Anesthesiology, Perioperative and Pain Medicine. After 20 wonderful years at Baylor College of Medicine, I'm deeply grateful to my outstanding trainees, colleagues, collaborators, and staff. Excited for this next chapter!

[Aaron Newman Lab @AaronNewmanLab]

1/ Thrilled to share our new paper, out today in @Nature: "Non-invasive profiling of the tumour microenvironment with spatial ecotypes".

Paper (open access): https://t.co/EujZFqU7wi

[Stanford Medicine @StanfordMed]

Spotlight on Nicolas Altemose, assistant professor of genetics: The Altemose Lab applies new tools and technologies to explore the biology of repetitive areas of the human genome.
https://t.co/rv8PS6ZjT4

[Felix Horns @FelixHorns]

Our new Comment is out today in @natrevbioeng. mRNA could treat many more diseases than it currently does, but we don’t have a way to get it to most of the cells where it’s needed. We explain why a cell will be the next transformative delivery vehicle⬇️

[Zihan Xu @xu_zxu]

PerturbFate is officially out in @Nature today! From chromatin to RNA, we dissect the causal regulatory logic linking genotype to phenotype. Huge thanks to my PhD advisor @junyue_cao @Wei_Zhou_1989, and @RockefellerUniv for providing such an incredible research home!

[Chad Weldy, MD, PhD @ChadSWeldy]

I am thrilled to say that I have accepted a position as Assistant Prof at @Stanford CV Medicine and am launching the Weldy Lab at Stanford!

My work integrates genetics, epigenetics, RNA biology, and cardiovascular disease.

Check it out: https://t.co/eb27xStRWM

Recruiting!

[Ali Max Erturk @erturklab]

in @CellCellPress, using iDISCO+ clearing & spatial transcriptomics, @nicolasrenier lab maps how cerebral vasculature forms across the whole brain. Reveals three phases—growth, specialization, refinement—linking vascular remodeling to neuronal maturation.
https://t.co/9d8IvaK9Rq

[brangwynnelab @brangwynnelab]

Fantastic weekend at the @brkthroughprize celebration, finally celebrating our Breakthrough Prize in Life Sciences with @HymanLab. What an incredible event!

[Ishmail Abdus-Saboor @IshmailSaboor]

This program transformed my career. Give it a shot!

@hhmi_science's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, + salary & benefits. Postdoc? This year's comp has a program for you too. Opens 11/3! https://t.co/OJQ5A7lHOT

[Ishmail Abdus-Saboor @IshmailSaboor]

Excited to share my lab’s new paper out today @CellCellPress.

"Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity"

Congratulations to this amazing team of scientists.

https://t.co/VYf1nfkWtB