Chris Bennett

Microglia enthusiast and psychiatrist

[Chris Bennett @FChrisBennett]

We wanted a safe and specific way to replace microglia, so we created one.

[Sonia Lombroso @Sonia_Lombroso]

Ending 2022 on a high note with the Bennett Lab’s first paper! Excited to finally share this work! TLDR: We (@FChrisBennett and @BlurtonJonesLab) engineered an inhibitor-resistant human CSF1R variant that can be used for microglial replacement. 🧵 below.

[Molecular Therapy Family of Journals @MolTherapy]

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells https://t.co/CZJ5zdobxF #genetherapy #celltherapy

[Molecular Therapy Family of Journals @MolTherapy]

CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies https://t.co/WdZOEU9EBZ #genetherapy #celltherapy

[Waggoner Lab @LabWaggoner]

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
https://t.co/8nmw1KqIRR
https://t.co/UuNBDs8m84 @MolTherapy @FChrisBennett @Sonia_Lombroso @BlurtonJonesLab @JPChadarevian
@UCIrvine @Penn

[Sonia Lombroso @Sonia_Lombroso]

Microglia replacement via vascular delivery and no toxic preconditioning? Now THAT is something I can get excited about. In our new paper we find that microglia replacement can now be achieved by peripheral delivery w/ no irradiation or chemo required.
👉 https://t.co/UK6HJRutZh

[Cody J. Smith @cssmity]

We are excited that our work describing microglia cannibalism is now officially in press! https://t.co/9mrfB0gC2Z

Stay tuned because we are on to the genetic mechanisms! 😀

[Jonathan Kipnis 🟦 @jonykipnis]

Thrilled to share new work from our lab led by ⁦@mitchkim_mw⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature https://t.co/Db86b5JKvv

[Mariko Bennett MD PhD (she/her) @nachoriko]

Interested in studying type I interferonopathy? Here is a primer on existing tools from the self proclaimed "AGS supergroup". https://t.co/QdokvDeOd6

[Michael P Hart 🏳️‍🌈 @MichaelPHart1]

New paper ALERT!! @MaraCowen discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab! https://t.co/UpUBIdbEqn

[Jenn Orthmann Murphy @JennOligoMyelin]

looking forward to tomorrow!!

[Ophir Shalem @ophirshalem]

Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines.
https://t.co/SBRXfWau75

[Jonathan Kipnis 🟦 @jonykipnis]

🚨Postdoc positions available🚨
If you have expertise in T cell biology (primarily TCR specificity/function) and/or in artificial intelligence, and if you would like to apply your knowledge to cool questions in #neuroimmunology, please email me for inquiry.

[Kahlilia Morris-Blanco @MorrisBLab]

One of the best ways to spend a sunny day in Philly is with these brilliant, creative,  and fun people! So honored to work with this awesome team! Happy #newpi Morris-Blanco Lab #strokeresearch

[CHOP Research @CHOP_Research]

Congrats to @ChildrensPhila's Dr. Evan Weber, recipient of the @NIHDirector's New Innovator Award! Dr. Weber will pursue a novel approach to reprogram T cells with enhanced tumor killing function, paving the way for more efficacious #cancer therapeutics.

@CHOPCancerCntr

[Mariko Bennett MD PhD (she/her) @nachoriko]

So delighted that one of my very favorite scientists and people Dr Allen is a Pioneer Awardee (you heard it here first!) woooohooo! @salkinstitute

[Mariko Bennett MD PhD (she/her) @nachoriko]

!!!!!!!!!!!!!! 🔥🔥🔥🔥💯💯💯💯💯🔥🔥🔥🥂🥂🥂🥂🤪👍👍👍

[Lucas Cheadle @LucasCheadle]

New protocols from Jessica Kahng and Andre Xavier for quantifying synapse engulfment by OPCs, based on foundational work from ⁦@SchaferLabUMass⁩ ⁦@stevens1lab⁩ ⁦@wonsukchung⁩ and others (1/4) https://t.co/VYDQe9JS7m

[JIRico @JuanInclanRico]

https://t.co/cgdK16JdGJ
Itching can be annoying but could it also be beneficial? Maybe it’s your body 🚨 you of a secret invasion… Our freshly baked manuscript is trying to answer these and other neuron, 🪱 and macrophage-related questions. (1/n)🧵 👇🏼

[Anand Bhagwat, MD, PhD @anandbmdphd]

Tremendously proud to share my fellowship work, online today in @NatureMedicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10
@PennMedicine @CHOP_Research @GillSaar https://t.co/Dkp8YsSYJ9

[SchaferLabUMassChan @SchaferLabUMass]

Thanks to all the support from @UMassChan @NeurobioUMass. It is a honor to be part of this community.

[Penn Medicine CSO @PennMedCSO]

Pooled endogenous protein tagging & recruitment for systematic profiling of protein function ft. @YSereb, Deepak Mani, @ophirshalem (@PennGenetics/ @CHOP_Research), @MaujeanT & @GMBurslem (@BB_UPenn/ @Penn_CBIO/ @PennEpiInst) @CellGenomics https://t.co/figonl7gag