#caseoftheday Tubular adenoma (a benign adnexal tumor) that, in this case, shows tubulo-cystic, papillary, eccrine, apocrine, and hydrocystoma-like features. In more than half of cases, the BRAF p.V600E mutation can be detected #pathology#dermpath#dermatology#PathX#MedX
A challenging case of a melanocytic lesion diagnosed as nevoid melanoma. Cytological atypia, mitotic activity, and loss of p16 expression supported the diagnosis. Interestingly, PRAME was negative #dermpath#pathology#dermatology#dermatopathology
New paper - Bilateral Metachronous Typical and Atypical Carcinoid Tumors of the Lung - Busetto - 2025 - Thoracic Cancer - Wiley Online Library https://t.co/55AhzeEal8 #pathology#lung#lungcancer
#WhatsNewInDermpath
"Conceptual contextualization of neutrophilic dermatoses" by @ngelFernndezFl1
https://t.co/5epFC3Mmml
This article discusses neutrophilic dermatoses & describes the connection b/w neutrophilic dermatoses, autoinflammatory diseases, & autoimmune diseases.
#ClinicalPathologicChallenge
63F with known Darier disease (DD) presented to the ED after 1 week of fevers, gastroenteritis, and rapidly progressive skin blistering and desquamation.
P/E: Diffuse epidermal sloughing with hemorrhagic crusting on the vermillion border
Trichilemmoma: a benign follicular tumor with characteristic CD34 immunoreactivity. Multiple trichilemmomas may be associated with Cowden syndrome #pathology#dermpath#dermatology#PathX#MedX
Calcinosis cutis is a crippling sequela of dermatomyositis, likely driven by ongoing inflammation, ischemia, trauma, and specific autoantibodies. Notably, there is marked thickening of the basement membrane, typical of the disease #dermpath#pathology#dermatology#rheumatology
#caseoftheday: Meyerson dermatofibroma. The Meyerson phenomenon is not limited to nevi. These images show classic features of spongiotic dermatitis associated with a dermatofibroma. Some cases have been reported (PMID: 36345407) #pathology#dermpath#dermatology
Undifferenziated/dedifferenziated melanoma: these tumors lack classical melanocytic markers and mimic sarcomas or carcinomas. Medical history and molecular profiling can guide the diagnosis #dermpath#pathology#dermatology#MedX#PathX#caseoftheday