@giovannilandoni@a_serpaneto The endothelin system is essential for endothelium homeostasis, HS and ET-1 have a complex bidirectional relationship. Heparin has been shown to decreased ET-1 production. Another drug that bind to HS and have shown antiviral effect is calcium dobesilate.
@jasminlaine It happened to me, I earned 15k more than the previous year. Child support reduced by $100, lost child care subsidy, now I am paying full cost for the before and after program, an extra $500/mo. So I lost roughly 7-8k + extra income tax.
@cremieuxrecueil It keeps the endothelium healthy. Endothelium ia the largest organ in the body and its dysfunction is a major factor in most chronic and autoimune disease: diabetes, CVD, Alzheimer's, Parkinson's, CKD, SLE, RA, SSc, Long covid. And also in COVID and HPAI.
Whoever is in charge of the Cons media game, they are nailing it. This is actually very good & well worth your time to watch. Excellent information
@outbreakupdates There is drug that can reduce mortality significantly,, it could have helped against COVID but the medical establishment choose to ignore it. Hopefully they will pay attention this time.
https://t.co/JpIQlvOiXZ
A 4 mile away conversation would have a 22.21 second delay between the words being said and heard due to the speed of sound at that temperature. Imagine it for a moment.
"It's cold out here!"
...
...
22.21 seconds later, the other guy hears it, and responds
...
...
"No shit!"
@dronico@psrivats_mdphd @farid__jalali Have you seen this one? NO and ET-1 are the main effectors of the dilation/constriction of blood vessels during various physiological processes including maintaining endothelium elasticity.
https://t.co/yXjYLYZetn
A new study shows that SARS-CoV-2 infection causes vascular dysfunction due to the modification of endothelial cell elasticity.
The results for the first time show that SARS-CoV-2 infection directly changes endothelial elasticity and causes endothelial dysfunction. 1/
@EuAlePavanelli Roubei o celular do meu marido pra comentar: Ser pai e ter q ajudar as crianças a estudar em casa é muito difícil, às vezes achamos que somos os únicos a nos frustrar. Parabéns aos pais pela coragem em compartilhar, mas seria bom "borrar" os personagens pra proteger os envolvidos
@ZimermanRicardo Essa sinalização exagerada de ATII eleva níveis de endotelina-1. Existe uma vasta literatura dos efeitos da ET-1 no endotélio e sistema cardiovascular. Oxido nítrico é o contrapeso da ET-1 no sistema endotelina, o equilíbrio entre os dois é essencial pra um endotélio saudável.
@TakeWeightOffMD@Aguirre1Gustavo Yes, endothelial cells should be the target if you want to treat COVID properly. Aminaphtone stabilize endothelial cells, decrease blood viscosity.
@nilocobau Yes! I struggled when I moved to Canada, floor plans are terrible here too. Kitchens with poor circulation, buildings with very little amenities.