Filiano Lab

We study neuroinflammation, autoimmunity, and rare diseases.

[Filiano Lab @FilianoLab]

Happy to drop this in the New Year. Learn how the “tough momma” regulates her house. @JExpMed @Dukeneurosurg
https://t.co/jKMTtNYBcl

[The Journal of Immunology @J_Immunol]

A special issue curated by guest editor @FilianoLab at @Dukeneurosurg highlights nine reviews discussing the multi-directional communication that occurs between the central nervous system, the surrounding tissues, and the immune system. Read it now: https://t.co/WNmvDh3B6s

[Filiano Lab @FilianoLab]

Was a blast guest editing this special issue for @J_Immunol . Check out these amazing reviews on brain border sites.

https://t.co/JqFw5TGHFH

[Danny Saban @SabanLab]

Check out our new preprint on a novel neuro-immune niche that underpins touch sensation.

[Filiano Lab @FilianoLab]

@jonykipnis @ImmunologyAAI @LukensJohnR Covering all the landmark papers!

[Neuroscience News @NeuroscienceNew]

Immune System Gene Linked to Hyperactivity, ADHD and Autism

Researchers have identified a link between the immune system and hyperactive behaviors, highlighting the role of the STAT1 gene in regulating behavior.

STAT1, a key regulator in immune responses, appears to influence brain development and function, particularly in dopamine neurons responsible for learning, memory, and motivation.

In mouse studies, prolonged activation of STAT1 during embryonic development led to hyperactivity, fewer neurons, and reduced neural activity in critical brain regions.

The findings suggest that disruptions in STAT1 signaling may contribute to neurodevelopmental disorders like autism and ADHD.

Researchers are now exploring whether the STAT1 pathway could be targeted for future therapies.

[Filiano Lab @FilianoLab]

Study in Mice Links Immune System to ADHD, Neurobehavioral Conditions https://t.co/CNEXBqJL3a

[Filiano Lab @FilianoLab]

@Dukeneurosurg Thanks Sarah Avery and Carol Harbers for this great coverage of @immunodani’s study

[Duke Neurosurgery @Dukeneurosurg]

New study from @FilianoLab links immune system to neurobehavioral conditions: "This work may have implications for ADHD, autism, and schizophrenia and open doors for investigating other conditions like Parkinson’s and substance abuse disorder." https://t.co/wBK53g6MH9

[Ashley St. John Lab @StJohnLab]

Check out our review "Mechanisms and risk factors for perinatal #allergic disease", led by Jozef and with @Abhay_R_. I♥️ how he simplified the complexities of allergies at the #maternal/#fetal & maternal/#infant interface. Authors' link for full access: https://t.co/HGhEdHUOza

[Filiano Lab @FilianoLab]

@jonykipnis Nice! Can’t wait to curl up in front of the fire with this one.

[Filiano Lab @FilianoLab]

@jonykipnis Ha, ya. Also looks like an Otter cracking a hippocampal clam

[Filiano Lab @FilianoLab]

Today I was discussing the evolutionary differences in the mouse and human brains. Please feel free to use this in your lectures. Really, you don’t even need to give me credit.

[Filiano Lab @FilianoLab]

@ImmunologyDuke @Dukeneurosurg

[Filiano Lab @FilianoLab]

Excited to share our labs latest work looking at how Prolonged STAT1 signaling in neurons causes hyperactive behavior. We think this could have implications for ADHD and other neurological conditions affecting the basal ganglia. @immunodani

https://t.co/CJomZi3dqv

[Filiano Lab @FilianoLab]

This was the final chapter to Dr. Clark’s thesis and can’t wait to see how much see accomplishes in her career.

[Ashley St. John Lab @StJohnLab]

Did you know that the fetal immune system can protect from congenital infection before birth? -Proud to share our study identifying protective functions of #microglia, contrasting the harmful early influence of #monocytes and primitive macrophages to #zika virus infection.

[Jonathan Kipnis 🟦 @jonykipnis]

Thrilled to share new work from our lab led by ⁦@mitchkim_mw⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature https://t.co/Db86b5JKvv

[Journal of Experimental Medicine @JExpMed]

Hyunjung Min et al. @FilianoLab reveal a mechanism by which mural cell–#macrophage interactions regulate the trafficking of CNS antigen-specific T cells to the dura. https://t.co/JFdBr0eFOD

📘 In our #Autoimmunity collection: https://t.co/VFgTlAKVYI

[Journal of Experimental Medicine @JExpMed]

Hyunjung Min et al. @FilianoLab reveal a mechanism by which mural cell–#macrophage interactions regulate the trafficking of CNS antigen-specific T cells to the dura. https://t.co/mmEkHxq4Cs

📘 In our #Neuroscience collection https://t.co/sUk5dzbTWI

#SfN24

[John Lukens @LukensJohnR]

🚨UVa Neurodegeneration job alert!! UVa Neuroscience is hiring multiple TT faculty in neurodegenerative disease research. If you're looking for a vibrant scientific community with wonderful colleagues then check it out! Please share/rt! @uvavpr @BIG_Center_UVA @UVANeurology