Francesco Moiraghi

Breaking symmetries @unrulyvc

[Stefano ₿Ξrnardi 🌲🏴 @stefanobernardi]

https://t.co/DTU6KyZiBG

[Francesco Moiraghi @FraMoira]

@SterlinLujan @Logos_network enjoyed this so much

[Roxana λ (TheHat) @roxananasoi]

Congratulations @FraMoira and @SterlinLujan for a great discussion on Sovereignty at Parallel Society this morning.

The Q&A was 🔥🔥🔥

[Logos @Logos_network]

Unruly Capital is a London-based venture firm that backs early-stage founders building transformative tech.

Focusing on health, climate, manufacturing, and frontier tech, @unrulyvc's approach to data transparency sets them apart from many VCs.

Catch Unruly’s @FraMoira and his talk on "Thinking Sovereignty".

11 AM @ The Lab.

[Aeron Laffere @aeronlaffere]

London's oldest parish church will be hosting Coordinating British Progress on February 20th.

Featuring speakers from @sotalikesfuture, @lfg_uk, @BritishProgress, @civic_future, @RenPhilanthropy, @ARIA_research, and some of the most exciting companies leading the way to Britain's future.

Spaces are now limited so be sure to confirm here, as we won't be able to admit anyone not on the list: https://t.co/qNHpOPCodP

[Francesco Moiraghi @FraMoira]

@tomough @AtelierMissor_ @sineiudicio What am I witnessing

[Julian Englert @julian_englert]

Can Claude Code design proteins?

We're just about to release our wet lab API + SDK so we made a quick demo to test how agents can interact with protein design models and submit the proteins to our lab for testing.

This closes the loop between the computational design and the experiment validation

We queued up a bunch of agent-designed proteins for wet lab validation, will release the results in a couple weeks on @proteinbase

[Matthew Osman @thematthewosman]

Today we are excited to publish our first results and what we’ve learned so far in building the autonomous tissue foundry (blog post linked below).

Human tissue is one of the most valuable materials on Earth and we believe there is now a clear path to producing it at scale and at high margin.

Some early highlights from our first two programs (cortical and cardiac):
• 700 tissue constructs cultured, monitored, and analyzed over time
• 2.9M individual cells quantified through our AI phenotyping pipeline
• 60% and 49% improvement in hit rates across the two programs
• 94% and 68% reduction in search space
• Same platform transferred across tissue types, minimal retuning shows proof of concept of generalization
• 54% improvement in program speed from first to second tissue type
• >70% reduction in cost per experiment from first to last iteration

Instead of trying to fully decode morphogenesis upfront, we constrain the problem using developmental datasets, then let AI-guided, lab-in-the-loop optimization discover what works. Each iteration closes in weeks, generating reusable datasets that compound over time.

Our first post in a two-part series walks through our initial results and how we achieved control of a critical structural feature of natural tissue, polarity, across two distinct lineages with minimal retuning.

In the next post, we’ll focus on the unit economics of an autonomous tissue foundry.

link in bio

[Stefano ₿Ξrnardi 🌲🏴 @stefanobernardi]

A quick recap of what we spoke about at @unrulyvc 's Human Futures Summit!

Also, all talks now available here: https://t.co/zJIqMGmTIi

[Kyle Harrison @kwharrison13]

I cannot read this stuff and stay pessimistic. There is too much hope in these visions.

[Francesco Moiraghi @FraMoira]

@thematthewosman and @FabioZB_I are building one of the most important companies of our time.

A tissue foundry to make eternal life manufacturable, on-demand.

Great piece by @eryney_ok / @ashleevance

and thanks @shelbynewsad

[Ashlee Vance @ashleevance]

Mind-blowing scoop this morning on Polyphron.

They're building human tissue - ie parts of organs - to replace diseased and damaged parts of the body.

@eryney_ok delivered the goods on this one

https://t.co/JD4wOBEUeO

[Francesco Moiraghi @FraMoira]

And this was sick. We must build planets @jasonjoyride @calarsenc @tomough @ObadiaAlex @lucia_asanache

[Francesco Moiraghi @FraMoira]

@PMArslanagic @WorksInProgMag Great piece! must-read

[Stefano ₿Ξrnardi 🌲🏴 @stefanobernardi]

Today we're very excited to share the new, updated investment thesis for Unruly Capital.

Population decline is the #1 trend of the century - and what will shape the world in the coming decades.
At Unruly, we've been thinking about (and investing in) this for a while, and believe there is not much more important than this to focus on if you have a long term view of the world.

We took some time to write down what is happening, why, and what we can do about it. Would love to hear your comments on it.

[Francesco Moiraghi @FraMoira]

@ladanuzhna Brava! Incredible

[Francesco Moiraghi @FraMoira]

@ObadiaAlex @ARIA_research Incredible stuff!

[Francesco Moiraghi @FraMoira]

"We must fill the eyes and ears of all of us with things that are the beginning of a great dream. Someone must shout that we'll build the pyramids."

Nostalghia - Tarkovsky

[Francesco Moiraghi @FraMoira]

Excited to host the London Premiere of Planet with @jasonjoyride on December 3rd.

All founders building a new planet welcome.

https://t.co/E7Vf2ejfOr

[Francesco Moiraghi @FraMoira]

Hosted w/ our friends @ARIA_research, @RenPhil21, @netholabs.

@ObadiaAlex @calarsenc @lucia_asanache @maxie3000

[Halen Mattison @HalenMattison]

The dream behind General Galactic started more than 60 years ago.

We’re the team making it real.

Esse Quam Videri