Francesco Pesce

PhD fellow at Linderstrøm-Lang Centre for Protein Science @uni_copenhagen.
Working on protein dynamics and integrative methods in molecular simulations.

[Kresten Lindorff-Larsen @LindorffLarsen]

We look forward to welcoming our #TWIN2PIPSA collaborators in Copenhagen 🇩🇰 next week for our first workshop

If you're local, you are welcome to come and listen to the presentations by colleagues from @UCPH_Research. See programme for the talks below.

[Francesco Pesce @FrancPesce]

Very proud to see the last (and largest) project carried out during my PhD finally out.

Thanks to all contibutors and in particular to @TanjaMittag and @StJudeStructBio for hosting me to run experiments on our designs.

[Kresten Lindorff-Larsen @LindorffLarsen]

I'm excited to present @FrancPesce's work on developing, applying & testing a method to design intrinsically disordered proteins 🍝

While there has been much work on design methods for folded proteins, much less has been done for IDPs. 1/n

https://t.co/c3iqBtimbe

[Kresten Lindorff-Larsen @LindorffLarsen]

.@FrancPesce 's most recent paper is now published 📜

We studied the temperature-dependent 🌡️ conformational properties of the IDP Histatin 5 🍝 by combining enhanced sampling simulations with SAXS ⚡️, NMR 🧲 and CD 🤲 data

https://t.co/XD1JmBy6K3

[Kresten Lindorff-Larsen @LindorffLarsen]

Do you enjoy interdisciplinary science and are looking for a postdoc position?

We're looking for a PD with strong experience in MD simulations 🖥️ for our #DynaPLIX ERC Synergy project to integrate MD with with NMR 🧲 & time-resolved crystallography ⏱️⚡️

https://t.co/2n9WsJ2v8l

[Kresten Lindorff-Larsen @LindorffLarsen]

I'm proud to introduce you to the IDRome 👋🍝

We performed simulations of 29,998 IDRs from the human proteome and analysed sequence-ensemble-function relationships.

For a quick intro watch 🎞️👇 and then read: https://t.co/7BamqSlY61

[Francesco Pesce @FrancPesce]

It was extremely nice to conclude this journey by discussing the results of my work with this fantastic committee. Thanks @HenrietteAutzen, @jkoefinger and @alexander_buell!

[Kresten Lindorff-Larsen @LindorffLarsen]

Big congratulations to Dr. Francesco Pesce 🎉🥂🎓🇮🇹

@FrancPesce gave a wonderful talk about his work on integrative modelling of IDPs 🍝 ⚡️ 🧲 🖥️ and [secret stuff we’ll soon preprint] and defended his PhD in front of @jkoefinger, @alexander_buell & @HenrietteAutzen

Well done!

[Francesco Pesce @FrancPesce]

@KamilTamiola Thanks Kamil! Looking forward to our collaboration 😉

[Kresten Lindorff-Larsen @LindorffLarsen]

Why science needs a protein emoji 🍝 🧶 🥩 🫘

Read about the relentless work by @andrewwhite01 and my own minor role that led to the submission and rejection of a protein emoji

https://t.co/HSTv4CBqPl

[Francesco Pesce @FrancPesce]

Nonetheless, we could not achieve an optimal agreement with SAXS and Rh simultaneously, and we discuss the possible reasons and shortcomings that cause this.

[Francesco Pesce @FrancPesce]

New preprint with @LindorffLarsen!
We examine the temperature-dependent behaviour of Histatin5, a 24 residues-long disordered peptide that was previously characterized by experiments from @MarieSkepo and @BBKrage.
https://t.co/k1ZS48XpWY

[Francesco Pesce @FrancPesce]

Thanks to our previous works about integrative modelling of conformational ensembles of IDPs against SAXS (https://t.co/MV9JCmBjuT) and Rh (https://t.co/f6FCdrdPCM), we have improved the agreement of the simulations with experiments and confirmed the link between PPII and Rh

[Kresten Lindorff-Larsen @LindorffLarsen]

Today marks the last day in our wonderful #BRAINSTRUC consortium on integrative structural biology. Funded by @lundbeckfonden in 2016 and involving @PoulNissen @gregers_rom @LiseArleth @aelangkilde and (in the last years) also @BBKrage, this has been a wonderful experience 🎉🙏

[Kresten Lindorff-Larsen @LindorffLarsen]

PhD fellowship in structural bioinformatics available in the group in our #PRISM centre 🇩🇰

If you love proteins, know a bit of programming and like to do quantitative analyses based on protein structure and sequence, this might be for you.

https://t.co/MQqFbvm69j

[Francesco Pesce @FrancPesce]

"A cat mistook the HPC facility for a litter tray and my IDP simulation is only 100ns long" error

[ErrantScience @ErrantScience]

Just hope it's your cat! 🐈‍⬛

#cartoon #academia #science

[Kresten Lindorff-Larsen @LindorffLarsen]

THEY SAY THAT THE PROTEIN FOLDING PROBLEM IS SOLVED, BUT WHAT THEY ARE NOT TELLING YOU IS THAT WE REALLY HAVE NO CLUE HOW MOST PROTEINS ACTUALLY FOLD

[Kresten Lindorff-Larsen @LindorffLarsen]

Thank you reviewers 🙏

[Kresten Lindorff-Larsen @LindorffLarsen]

Meet the newest version of CALVADOS, our coarse-grained model for simulating intrinsically disordered proteins. CALVADOS 2 has been fully reparameterized and shows interesting effects from tuning long-range non-ionic interactions. Work by @GiulioTesei. 1/n
https://t.co/BYPEbLmqmA