Oded Friedman, MD MSc

Nephrologist

[Oded Friedman, MD MSc @FriedmanOded]

Hoping I live to see the day when renal regenerative medicine transforms this Star Trek IV movie scene from science fiction to non-fiction.

https://t.co/c2KgvheMfZ

[Oded Friedman, MD MSc @FriedmanOded]

@IzabelaZakrocka @Proximal_Baxi @TWhittier_RUSH @NephRodby @Rush_Nephrology @BajinderR @zainabo87 Remarkable but what’s the MCL —> C3G pathogenesis? By definition, can’t be MG-assoc C3G as no MG detected.

[Oded Friedman, MD MSc @FriedmanOded]

@GlassockJ @Proximal_Baxi @NephRodby @IzabelaZakrocka @GlomCon @Neph_SIM @Renalpathsoc @RenalFellowNtwk Does she have 3 diseases or at this point, ‘just’ 1 disease + 2 variants?

Considering the high prevalence of both TTR Val122Ile & APOL1 HR variants in Africans, the penetrance of each is clearly incomplete (also age-dependent) with intrafamilial variability.

[Oded Friedman, MD MSc @FriedmanOded]

@NephRodby @IzabelaZakrocka @JeanHouMD @TWhittier_RUSH @Proximal_Baxi @BajinderR @Rush_Nephrology (2/2)

https://t.co/xOUWhJaZ83

This showed no response to PLEX but did to ECU on top of EURO-CYC f/b RTX.

And it goes on & on like that.

[Oded Friedman, MD MSc @FriedmanOded]

@NephRodby @IzabelaZakrocka @JeanHouMD @TWhittier_RUSH @Proximal_Baxi @BajinderR @Rush_Nephrology (1/2)

Wish we knew whether LN with LV (lupus vasculopathy) needs different/more aggressive Rx approach, eg PLEX.

https://t.co/MmZ8Fimb7i

This suggests no difference in IS response but lumped all LV types.

[Oded Friedman, MD MSc @FriedmanOded]

@sijiezheng @askrenal Co-administer a SGLT2i.

[Oded Friedman, MD MSc @FriedmanOded]

@arkanalabs Accelerated ANS recently described in MPNs.
https://t.co/76IRcP3mNR

[Oded Friedman, MD MSc @FriedmanOded]

@kidney_boy Wouldn’t Fe deficiency be erythropoiesis-limiting & therefore desirable here? Isn’t that the rationale of rusfertide (= hepcidin mimetic) in PV?
https://t.co/tGVBsQJ5zF

[Oded Friedman, MD MSc @FriedmanOded]

@NephRodby 99.5%. For what 0.5% have I considered Rx with IVF + loop? 2 scenarios that come to mind are the euvolemic pt with either drug-induced crystal nephropathy or hyperK but admittedly not routinely.

[Oded Friedman, MD MSc @FriedmanOded]

@Proximal_Baxi @VelezNephHepato @aishaikh Also aligns with reported UE vein blood flows (Q) in that if ~ 10% artifactual Na drop from 130 mL/hr H2O, then Q = (130 x 0.9 / 0.1) / 60 = 20 mL/min.

[Oded Friedman, MD MSc @FriedmanOded]

@NephRodby

[Oded Friedman, MD MSc @FriedmanOded]

2 #spurious #urine lab abNs in #SGLT2i-treated pts:

1. Pseudohypercreatininuria with #Jaffe assay.

2. Pseudoethanoluria from #fermentation of C6H12O6 → 2 C2H5OH + 2 CO2 (‘auto-brewery’).

[Oded Friedman, MD MSc @FriedmanOded]

@nickmmark STAT CTA: R/O hyperemic bowel.

[Oded Friedman, MD MSc @FriedmanOded]

@NephRodby @askrenal @Glomkeeper An abN I haven’t seen much written about with ICO use is hyperCa/+ve diffusive Ca balance, esp in pts using > OD back-to-back & suspected low turnover bone, didn’t come as a surprise when I found out its high [Ca] = 1.75 mEq/L = 3.5 mmol/L.

[Oded Friedman, MD MSc @FriedmanOded]

@RhodesHambrick @BookBurton Along same line, some of the worst cases of hyperK I’ve seen among anuric ESKD pts were those who happened to also be colectomized.

[Assita Kanko MEP @Assita_Kanko]

Today, I have a question. A pressing question. For some Western feminists.
How can you remain silent, when women and girls are raped, tortured, their bodies carried around naked and spat on by bearded men shouting Allah Akbar?

Then you can never call yourself a feminist again.

Every day, including today, some Western hypocritical feminists should be ashamed of their silence on the horror that Hamas men inflicted to women and girls on 7 October.

And that includes big names we were once proud of.

Why are their lips sealed and their hearts of stone when it comes to the excruciating pain of Jewish women?

The MeToo movement and so-called intersectional feminists do not care about all women.

If they remain silent, it means they have lied to us about their commitment to women's rights.

Their actions support the oppressor, not the victims.

Also the EU money does.

Indirectly.

Those who say nothing about these women and the hostages, should not be standing here and speaking about human rights.

When you are under attack by terrorists, a cease fire is like raising your hands when you are being shot at.

Perhaps it is worth considering that a real lasting cease fire will start with bringing back all the hostages to their homes and the rapists to justice.

Assita

[Oded Friedman, MD MSc @FriedmanOded]

@MattiasMandorf1 Interesting as expected drug to only shift pathology of cholemic nephropathy from less proximal tubulopathy to more distal cast nephropathy. Hadn’t considered proximal cell debris to be integral to cast formation.

[Oded Friedman, MD MSc @FriedmanOded]

@AlanYuNeph @Distractio @NephRodby @BrianJL If chose to Rx, I might go with 3% saline (HS; + loop diuretic +/- SGLT2i too) vs tolvaptan (TO). In this observational study, mod-sev hypoNa was corrected by > 5 in 78% with HS = 81% with TO except more rapid response with HS.

https://t.co/12g3RhsHl3

[Oded Friedman, MD MSc @FriedmanOded]

@NephroMD Might this be b/c bolus (unlike slow continuous) urea exposure acts on IMCD too by exceeding UT-A1/3 reabsorptive capacity?

[Oded Friedman, MD MSc @FriedmanOded]

@ChristosArgyrop @NephRodby Doesn’t that depend on the anion’s identity? For eg, citrate ➡️ soluble complex ➡️ high tot Ca/low ion Ca until metabolized whereas HPO4/oxalate ➡️ insoluble complex ➡️ extravascular precipitation ➡️ low tot Ca/low ion Ca.

[Oded Friedman, MD MSc @FriedmanOded]

@NephRodby @shastriki @VijayanMD @NephJC (2/2)…I could never find any reported difference by gender (rather only by age with very young at ⬆️ risk) so your explanation makes a lot more sense.

[Oded Friedman, MD MSc @FriedmanOded]

@NephRodby @shastriki @VijayanMD @NephJC (1/2) Also, for the same body weight, water load & AVP level, worse hypoNa in females b/c ⬇️ %TBW & ⬆️ V2R expression. I recall reading herniation risk was ⬆️ too b/c ⬆️ brain : cranium volume ratio but