Azmavet G

Biologist | MSc. Immunology | PhD. Student in Immunology | Innate immunity, sepsis and intestinal permeability | I am a citizen of the whole world

[Azmavet G @GAzmavet]

@CMAS_Xalapa fuga de agua en esquina calle Obispo y privada de Paricutín, Unidad jardín.

[Azmavet G @GAzmavet]

@awamzzz Mi abuelo y mamá :) y de ahí viviendo solo y buscando recetas

[GRITCULT @GRITCULT]

latest studies show that short form videos

- lower your iq
- make you anxious
- make you stressed
- induce mental illnesses

[William A. Wallace, Ph.D. @WilliamWallace]

What actually happens to caffeine after you drink it?

your liver breaks caffeine into three separate biologically active molecules, each with different effects.

This pathway shows exactly how your body metabolizes caffeine, and why people respond so differently to the same cup of coffee.

When caffeine enters the bloodstream, 95% of its metabolism occurs in the liver and is controlled by the enzyme CYP1A2, one of the most genetically variable drug-metabolizing enzymes in humans.

Caffeine (1,3,7-trimethylxanthine) is broken down into three major metabolites:

1️⃣ Paraxanthine (1,7-DMX) - 84% of caffeine metabolism

This is the dominant metabolite.
Paraxanthine increases lipolysis, raises free fatty acids, and enhances alertness without as much vasoconstriction as caffeine itself.
Further metabolism produces AFMU, 1-methylxanthine, and 1-methyluric acid through NAT2 and XO pathways.

2️⃣ Theobromine (3,7-DMX) - 12%

Theobromine is the primary stimulant in chocolate.
It acts as a vasodilator, smooth muscle relaxant, and mild diuretic.
It is further metabolized into 3,7-dimethyluric acid via xanthine oxidase.

3️⃣ Theophylline (1,3-DMX) - 4%

Theophylline has bronchodilating properties and is actually used clinically for asthma.
It is metabolized into 3-methylxanthine and 1-methylxanthine through CYP1A1 and CYP1A2 pathways.

🧬 Why this diagram matters

Genetics determine how fast you metabolize caffeine.

Fast metabolizers (CYP1A2*1A) clear caffeine quickly → fewer jitters, higher tolerance, shorter half-life.

Slow metabolizers (CYP1A2*1F) break it down slowly → stronger effects, longer half-life, higher risk of sleep disruption and blood pressure effects.

NAT2 and other enzyme variants shape downstream metabolite balance.

This is why some people can drink coffee at 9 p.m. with no issue…
and others get heart palpitations from half a cup.

Your caffeine response isn't random, it's biochemistry + genetics.

📚 Source
Nehlig A. “Inter-individual differences in caffeine metabolism and factors driving caffeine consumption.”

[Neil Renic @NC_Renic]

Do a PhD

[Alerta News 24 @AlertaNews24]

🇺🇸 | AHORA: Microsoft anuncia que ha desarrollado un sistema de inteligencia artificial que crea un "camino hacia la superinteligencia médica" que puede lidiar con casos "diagnósticamente complejos e intelectualmente exigentes" y diagnosticar enfermedades con cuatro veces más precisión que un panel de médicos.

[¿Por qué es Tendencia? @porktendencia]

"La OEA":
Por su informe preliminar sobre las #EleccionesJudiciales.

[Rosana Ferrero 📈📊🙌 @RosanaFerrero]

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[Scholarship for PhD @ScholarshipfPhd]

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[Ángel M. Delgado-Vázquez @amdelvaz]

La semana pasada estuve impartiendo un breve curso para introducir las herramientas de #inteligenciaartificial en #investigación en el @ire_ub de la @UniBarcelona Os la dejo por aquí por si os interesa https://t.co/FfImU6dzQd

[Kirk Borne @KirkDBorne]

#Python #MachineLearning By Example: https://t.co/3mO7oBt4gc v/ @PacktPublishing
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——
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[Luis Arturo Herrera @RealArturoH]

Este símbolo ☭ debería causar la misma repulsión y rechazo que este 卍. Bajo la bandera del socialismo se hicieron genocidios, hambrunas, y en una ocasión casi provocan que Europa y parte de Asia quedaran completamente inhabitables (Chernobyl).

El socialismo es muerte y miseria.

[𝑷𝒖𝒏𝒌 𝒚 𝒄𝒖𝒓𝒔𝒊 @punk_y_cursi]

Domingo de bajón.

[Scholarship for PhD @ScholarshipfPhd]

If God helped you start, He will help you finish.

[Job Corner @JOBCORNER247]

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[blue @bluewmist]

read this. definitely worth your time.

[iyah may @iyahmaymusic]

Thank you to everyone supporting my song ‘Karmageddon’. As some of you might know I am now an independent artist after I lost my manager because I didn’t change the lyrics of this song, and also left my label. Your support means the world. If you’d like to hear the full track click this link: https://t.co/8xhXASDE38

[Jotaaa🇪🇸 @jotabanderita]

Hemos normalizado que haya gente que se sienta superior por devorar literatura barata y superficial

[PNASNews @PNASNews]

Researchers challenged longhorn crazy ants and humans with the same task: maneuvering a T-shaped object through two consecutive open doorways. Single humans always outperformed single ants, but ant groups could beat human groups. In PNAS: https://t.co/nV1ZXoFpSh

[Python Developer @PythonDvz]

Mathematics Concepts Required For Data Science 🔥🚀 https://t.co/7kiL3uhZf7

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