✨ Latest exciting story of @haploteam in @Nature. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how SVs shape the phenotypic landscape.
@InstUnivFr@ERC_Research@CNRSbiologie
https://t.co/RE7ec6K6Ru
Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6
Our ScRAPdb paper is finally out at @NAR_Open > https://t.co/xtFRx6BReF , in which we assembled a #pangenome x #multiomics database for the iconic model organism S. cerevisiae. This is one step forward for the ScRAP project and we expected many more to come. Read more >
couldn’t agree more about the need for more computational biologists. More importantly, we must ensure they receive the recognition and support they deserve. Their work should never be dismissed as merely “just service”. Additionally, I’d like to remind everyone of the excellent paper titled ‘All Biology is Computational Biology’. 🧬 💻
Shout out for the 15th Chinese Conference on Yeasts and Fungi (June 14-17, 2024). This meeting is organized by the community and for the community, and it goes fully international now. Bonus: Nobel Laureate Dr. Paul Nurse has confirmed to attend the meeting!
Lichen are a big deal on earth. First off, they’re GORGEOUS but also they cover 6–8% of Earth's land surface! We know of 20000 species but there are likely MANY MANY MORE.
We estimate that we’ve only discovered 10% of fungi, as opposed to 85% of plants.
1/ Today in Science, we train a neural net from scratch through the eyes and ears of one child. The model learns to map words to visual referents, showing how grounded language learning from just one child's perspective is possible with today's AI tools. https://t.co/hPZiiQt6Vv
Our mammalian cell programmable reaction-diffusion plasmid pack is now on Addgene--everything you need to get started making waves, analyzing images with DSP, and interfacing with cell biology! Have fun and reach out if you need help/have questions 😵💫https://t.co/T4IVieWGre
Our new study led by @SakenovaNazgul from the @TypasLab at @embl is out ! If you want to learn more about inferring cross-resistance and collateral sensitivity between antibiotics from chemical genetics datasets, please check it out !
https://t.co/fJ2AGt0wF4
How stable are bacterial genomes as they adapt to an environment? My collaboration with @anuraglimdi, @EvolSys, @RELenski, and @ten_olivier exploring this over 50,000 generations of evolution is out today!
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https://t.co/q7WwMo1LvY
We have a new paper out on the ecological basis of hybrid incompatibilities! We argue, via literature review, two meta-analyses, and simulations that epistatic incompatibilities might underlie much of what is known as 'extrinsic' post-zygotic isolation https://t.co/kblZWF0bhr 1/n