Gemma R-M, PhD

She/her Post-Doc in Cancer Biology and Genomic Sciences
🏳️‍🌈

[Stonewall @stonewalluk]

If you were given £25,000, what would you buy? 🤔 For many lesbians, bi women, and trans people, that’s how much it could cost to start a family via IVF. #IVFforAll

✉️ Join @WhatWeganDid in ending fertility inequality and email your MP: https://t.co/YMgFRUP7CM

[richard white @whitefishlab]

An important piece about the "scissor" of gender representation from @Johanna_A_Joyce. When we were colleagues at @MSKCancerCenter she was the person who really opened my eyes to this. Check it out: https://t.co/VmcmKBA712

[Davies Lab - CH3 @DaviesLab_CH3]

😃😃Another PhD opportunity in ⁦@DaviesLab_CH3⁩. This time investigating the chromatin role of PRMT1 via the methylation of a novel substrate. Deadline 12th Jan. come join us!! ⁦@Impact_Aim_Mrc⁩ ⁦@PetermannLab⁩ ⁦@IcgsUob⁩ ⁦ https://t.co/frrouc8hK5

[Davies Lab - CH3 @DaviesLab_CH3]

Exciting 🎉🎉🎉🎉PhD opportunity in my lab investigating the role of PADI enzymes and citrullination in genome stability. Deadline 4th Jan. Come join our fantastic team!!! https://t.co/MtuRhnzvU4

[Gemma R-M, PhD @Gemmarm1]

Congratulations on this incredible story!

[Krithika Venkataraman, PhD @kritvenks]

My thesis work, the curiouser and curiouser case of tweedledee and tweedledum is out at long last - @eLife version of record here: https://t.co/YZY7doyCLV. Biggest thank you to @leslievosshall, PhD advisor extraordinaire, and the best collaborators. 👇🏾for a thread (in gifs).

[Krithika Venkataraman, PhD @kritvenks]

True story!👇🏽 7 years of @RockefellerUniv wonderland later, here we are with a wild story about female reproductive resilience in deadly disease-transmitting mosquitoes. Come join us down the rabbit hole!

[Krithika Venkataraman, PhD @kritvenks]

Enormous gratitude to @leslievosshall, my truly *fantastic* PhD advisor @RockefellerUniv @HHMINEWS, and my brilliant, inspiring collaborators. Thank you for embracing the weird and wonderful with me!

[Krithika Venkataraman, PhD @kritvenks]

My PhD paper is live @eLife! Settle in for a tale of female mosquitoes flexibly extending their “pregnancy” in response to drought conditions, a striking behaviour driven by a curious pair of rapidly evolving genes — tweedledee & tweedledum. Fully formatted version coming soon!

[Gemma R-M, PhD @Gemmarm1]

@kritvenks @eLife Congratulations! What fantastic work!!

[Gemma R-M, PhD @Gemmarm1]

Excitingly single-molecule data revealed that the rescue stemmed from allowing sister replication forks to progress at equal rates. 3/3

[Gemma R-M, PhD @Gemmarm1]

Thrilled to share our highly collaborative work uncovering the delicate balance between Pol2’s polymerase and exonuclease domain activity! Congratulations to my co-first authors @mxz0309 and Clemence and of course Iestyn and @ZhaoLab_SKI
https://t.co/V0eh1EbPIG
1/3

[Gemma R-M, PhD @Gemmarm1]

We show that multiple defects caused by mutations of a conserved subdomain of the catalytic core, including impaired growth and DNA synthesis and genome instability, were rescued by exonuclease inactivation. 2/3

[SGD Project @[email protected] (bsky too) @yeastgenome]

🌟New SGD blog post! 🌟 Regan-Mochrie et al reveal key role of #sumoylation in regulating #genome #replication - hypersumoylation interferes with MCM loading, hyposumoylation allows increased origin firing https://t.co/5VQqJ3crqk @GenesDev #yeast

[Xiaolan Zhao Lab @ZhaoLab_SKI]

Congrats, Gemma! What an outstanding defense; we are very proud of you 👏👏😀 😃

[Gemma R-M, PhD @Gemmarm1]

Both hypersumoylation and hyposumoylation of ORC result in genome instability providing evidence that appropriate ORC sumoylation levels are important for cell fitness. 3/3

[Gemma R-M, PhD @Gemmarm1]

I'm extremely excited to share our work uncovering the role of ORC sumoylation in fine-tuning origin licensing! Many thanks to our collaborators
@CatherineFoxLa1 @LabRemus @nbhagwat @HunterMeiosis and of course @ZhaoLab_SKI
1/3
https://t.co/H32eVo8PKB

[Gemma R-M, PhD @Gemmarm1]

We show that ORC hypersumoylation preferentially reduces the function of a subset of early origins, while Orc2 hyposumoylation has the opposite effect. Mechanistically, ORC hypersumoylation reduces MCM loading in vitro and diminishes MCM chromatin association in vivo. 2/3

[Shibai @Shibai6]

Happy to share our latest paper about how Smc5/6 complex clamps DNA. Great experience work with @You Yu, ⁦@ZhaoLab_SKI⁩ @Petal Lab_SKI. https://t.co/S2T4ulmmDn

[Gemma R-M, PhD @Gemmarm1]

Congratulations on such an exciting study!

[Paige Arnold @paigearnold2]

I’m beyond thrilled that our paper identifying a ‘non-canonical’ TCA cycle active in cancer cells and stem cells is out today in @Nature ! @__btjackson @LucasBSullivan @lydfinley @MSKCancerCenter @GSKGradSchool 1/n

https://t.co/bY3Y5BUtIZ

[Gemma R-M, PhD @Gemmarm1]

Congratulations @paigearnold2! Extremely well deserved recognition of all your hard work!

[GSK Graduate School @GSKGradSchool]

GSK Graduate Student Wins Prestigious Award for Outstanding Achievement in Biological Sciences https://t.co/4RqEUHBN7r