Prof Mark D Gorrell

Biochemist @CentenaryInst @Sydney_Uni interested in DPP4-like enzymes, and liver diseases, diabetes, cancer and Covid-19 therapies and pathogenesis.

[Prof Mark D Gorrell @GorrellProf]

@SeanDentBsc @Andrewp37075755 Hi Sean. I agree with you; synergy is more likely than competition.

[Prof Mark D Gorrell @GorrellProf]

We all want safer and more effective tumour treatments. This interview presents thoughtful expert clear views on how chemistry and immunology can harmonize for efficacy . https://t.co/FoWxCdUatM

[Prof Mark D Gorrell @GorrellProf]

FAP is a magnificent target for treating solid tumours, cirrhosis, arthritis, fibrosis in lung, heart or kidney, or endometriosis. FAP targeting increases efficacy while decreasing side effects. My new review is
https://t.co/e2RRlYIHfc
#centenaryinstitute

[Prof Mark D Gorrell @GorrellProf]

@RAH00084 @Blueberrymgmnt Yes, I would love see this idea tested on sera from treated patients. I would also like to see more of the great work done by FAP targeting companies published. My review was written 6 months ago and was limited to discussing published work.

[Prof Mark D Gorrell @GorrellProf]

@Blueberrymgmnt Avacta is at the forefront of precision oncology and going great, so don’t sweat it.

[Prof Mark D Gorrell @GorrellProf]

@RAH00084 To answer your question, consider that 6000 and 6103 have different warheads , so each should be used to treat tumors that are vulnerable to the appropriate warhead.

[Prof Mark D Gorrell @GorrellProf]

@thomasrcox @NatureCancer @SyntaraTx @GarvanInstitute @ecmcongress Great science Tom. I enjoyed your talk.

[Thomas R. Cox @thomasrcox]

Great fun presenting some of our labs work at the 2024 ECM Pharmacology Congress including our recent @NatureCancer work on pan-LOX inhibitors in pancreatic cancer in collaboration with @SyntaraTx #ECM2024 @GarvanInstitute @ecmcongress | https://t.co/L2eJT2AkEQ |

[International Proteolysis Society @IntProtSoc]

We would like to remind you that registration for the next IPS webinar "Many Roads to Inflammation" by Vishva M. Dixit, Vice President of Early Discovery Research at Genentech Inc, on November 20 is still open on IPS website : https://t.co/7nXWJuefUB. Make sure not to miss this!

[Prof Mark D Gorrell @GorrellProf]

@VanessaPirotta @sammyjcomedian @abcmelbourne I agree that fear is a likely cause of this huddle; what caused their fear? Sounds?

[Prof Mark D Gorrell @GorrellProf]

Fascinating novel work: HIV infected CD4 cells killed by Val-boro-Pro or 1G244. Congratulations @LShanlab

[Nature Chemical Biology @nchembio]

A new paper from @LShanlab and @KolinClark39 @Wustldbbs @WUSTLmed found that non-nucleoside reverse transcriptase inhibitors drive HIV protease-mediated CARD8 inflammasome activation, which is attenuated by DPP9. Free to read: https://t.co/pGAX2ANV8X https://t.co/X1KJ71GMHC

[Prof Mark D Gorrell @GorrellProf]

@jodieingles27 @heartfoundation @GarvanInstitute @dgmacarthur @LauraYeates1 @alexbutters25 @judydo26 @FergusS13 @neeshakrishnan @EbonyR_GC @amy_baker29 Jodie, You exhibit exceptional skill and talent. Your clients and colleagues win.

[Prof Mark D Gorrell @GorrellProf]

@CassHarapas @sethmasters @ReversadeLab @KimSamirah @WEHI_research @ASTARsg @NTUsg Brilliant work. I am thrilled to have helped you.🎉

[Prof Mark D Gorrell @GorrellProf]

Massively pleased in my role in these discoveries on DPP9 in humans. Now understand DPP9 is fundamental in humans, mice and fish. Congrats to @CassHarapas @sethmasters @ReversadeLab

[Science Immunology @SciImmunology]

New research involving humans, mouse models, and zebrafish clarifies how a protein complex called NLRP1 inflammasome encourages immune disorders. @WEHI_research @NTUsg @ASTARsg

https://t.co/4USj1RJuVa

[Science Immunology @SciImmunology]

New research involving humans, mouse models, and zebrafish clarifies how a protein complex called NLRP1 inflammasome encourages immune disorders. @WEHI_research @NTUsg @ASTARsg

https://t.co/4USj1RJuVa

[Prof Mark D Gorrell @GorrellProf]

Great to see: DPP9 selective inhibition is much needed.

[Prof Mark D Gorrell @GorrellProf]

@kellerlauraj @taylorhnguyen @ajodonoghue @MJNiphakis @MLakeme @mbogyo Excellent work @kellerlauraj - that will urge us to think about what bacterial proteases digest.

[Ruth Geiss-Friedlander @Ruth_G_F]

Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair https://t.co/IWVARfjpbc
Excited to share our newest work showing a role for DPP9 in repair of DNA damage. We show that the protease DPP9 determines BRCA2 stability and regulates HR repair!

[Stuart Turville @StuartTurville]

https://t.co/dVFteopp2G

Our snapshot of clinically isolated BA5 virus:
1- Antibodies derived from thousands of donors observes all Omicron variants (esp. BA1, BA2 & BA5) are evasive.
2- Potency of Evusheld and Sotrovimab reduced.
3- Tropism shift back to using TMPRSS2

[Prof Mark D Gorrell @GorrellProf]

The pandemic rages, so be careful: In NSW alone there are over 1700 in covid wards.

[dbRaevn @dbRaevn]

📊AUS - Deaths