Gregory Lepeu

MD-PhD, resident in Neurology. Epilepsy / Electrophysiology / Systems Neuroscience

[Gregory Lepeu @GregoryLepeu]

1/10 Can ideas from dynamical systems theory be used to gauge cortical excitability and predict epileptic seizures in vivo? 🧠In my PhD research, out in @NatureComms, we tested this idea and identified dynamical signatures of seizure risk. #Epilepsy #Neuroscience

[Gregory Lepeu @GregoryLepeu]

Bold this In Athens for the European Epilepsy Congress! 🇬🇷

I’ll be presenting “Paradoxes and Dynamics of the Post-Ictal Refractory Period” on Tuesday at 13:10 during Basic Science 2.

Looking forward to seeing many of you there.

[bioRxiv Neuroscience @biorxiv_neursci]

REM sleep reconfigures large-scale network dynamics: a link to its suppressive role in epilepsy https://t.co/hTHJKV8P6z #biorxiv_neursci

[Gregory Lepeu @GregoryLepeu]

Extensive circuit-level dissection points to a (partial) role for lateral hypothalamic MCH neurons. Opening exciting avenues to predict and reduce cataplexy.

[Gregory Lepeu @GregoryLepeu]

🔥 Temperature matters in narcolepsy!
Really nice translational neuroscience work by Bianca and colleagues, showing how decreasing temperature triggers cataplexy (while suppressing REM sleep) in narcolepsy type 1.
https://t.co/2A7TlqJYNN

[IFCN and its Clinical Neurophysiology journals @ClinicalNeuroph]

[Critical Care EEG] Lepeu and Rossetti: "In our registry of adult comatose cardiac arrest patients over 9 years, 735/976 had EEGs performed between 36–72 h; only 7 (0.95 %) met criteria for alpha or alpha–theta coma." https://t.co/g0RLhIOhjl
#CriticalCareEEG

[Nature Neuroscience @NatureNeuro]

The brain’s wake-to-sleep transition follows bifurcation dynamics with a distinct tipping point preceded by a critical slowing down

@nir_grossman @Junheng19 @ISN_Lab @UKDRI

https://t.co/HHskXavq4Y

[Gregory Lepeu @GregoryLepeu]

New paper out! We present a short, didactic case report/series on the rare EEG pattern of alpha coma, discussed in the context of post–cardiac arrest neuroprognostication.
https://t.co/NWeYnwbTFM

[Michael Wenzel @Maikl_Wenzel]

Cover story just out in Science Transl. Med.! https://t.co/Ilwgllr4Dr. Our 5-yr project in mice & humans on spreading depolarization (SD) in epilepsy! Huge Thx to collab labs @HeinzBeck8, @humansingleunit, @simonMusall, @LalaEwell! 1/2

[Jan Lepeu @jan_lpe]

I had the pleasure to appear in Jan Dunin-Wasowicz's podcast to discuss the past, present and future of EU sanctions. Among other things how the Russia sanctions differ from previous uses, where EU sanctions come from, and how they have evolved over time. https://t.co/5J571MolAo

[Stravoguine @stravoguine]

Des intelligences aliens existent déjà sur Terre — et non, elles ne sont pas artificielles !
Un thread sur les oiseaux, leur cerveau et l’évolution de l’intelligence 🧠🦜🧵

[Alberto Averna @AAverna7]

Embarking on a new era in sensing-based neuromodulation! ⚡🧠
We've demonstrated the potential of commercial devices—Medtronic Percept and Apple Watch— to track circadian rhythms, dopaminergic states, and dyskinesia symptoms in PD patients.🚀
https://t.co/pcJhuJtOAC

[Gregory Lepeu @GregoryLepeu]

New review article: Gauging and controlling excitability in cortical disorders : Current Opinion in Neurology https://t.co/TfZknq3Ys5

[Brain @Brain1878]

Many people living with epilepsy continue to have seizures despite medical treatment. Trevelyan et al. review the use of brain stimulation in epilepsy, and consider how recent advances in preclinical research could be translated into clinical practice. https://t.co/es4OqoRgmO

[Jan Lepeu @jan_lpe]

🚨 New Year, New Publication:
For the upcoming International Politics Forum on the (re-)organising of European Security following the
🇷🇺 invasion of 🇺🇦, I wrote this article focusing on the sanctions pillar of the 🇪🇺 response to the full-scale invasion.
https://t.co/4F1Vn0N2zh

[Michael Wenzel @Maikl_Wenzel]

Check by a 5yr journey of the lab in mice & humans, just up on bioRxiv! Post-ictal symptoms can be life-threatening, & basic mechanisms are mostly unclear. 1/2 https://t.co/7A2ZEW0VLL

[Gregory Lepeu @GregoryLepeu]

1/10 Can ideas from dynamical systems theory be used to gauge cortical excitability and predict epileptic seizures in vivo? 🧠In my PhD research, out in @NatureComms, we tested this idea and identified dynamical signatures of seizure risk. #Epilepsy #Neuroscience

[Fosco Bernasconi @BernasconiFosco]

Great PhD opportunity with Gilles Allali! on hallucinations, delusions, cognitive functions in neurodegenerative diseases. Come work with us https://t.co/F3jJlejweH
@OlafBlankeLab @CHUVLausanne

[Gregory Lepeu @GregoryLepeu]

@IreneLenzi1 @NatureComms Thanks Irene :)

[Gregory Lepeu @GregoryLepeu]

1/10 Can ideas from dynamical systems theory be used to gauge cortical excitability and predict epileptic seizures in vivo? 🧠In my PhD research, out in @NatureComms, we tested this idea and identified dynamical signatures of seizure risk. #Epilepsy #Neuroscience

[Gregory Lepeu @GregoryLepeu]

10/10 The full paper is in #OpenAccess here: https://t.co/vYBvLLRTHo.
Study conducted at @unibern @inselgruppe @DBMR_UniBe and funded by @snsf_ch .

[Gregory Lepeu @GregoryLepeu]

9/10 A huge thank you to all collaborators, especially @ellen_mvm , who set up the intracranial stimulation and recording in humans; Tim @NeuDyLab for his contribution with modeling and his dynamical insights; and @Tidis__ and Maxime, who guided me through this complex project.