Sandeep Gupta

Assistant Professor of Cell Biology, U Alberta. Developing next- generation of stem cell models for diseases and regenerative medicine.

[Sandeep Gupta @GuptaLabUofA]

First lab meeting of the Gupta lab. very exciting start!
We are building functional stem cell models to investigate neurodevelopmental disorders like autism

[Ryuta Koyama @ryuta_koyama]

Transcriptome-based classification in mice with ASD-risk mutations
https://t.co/ZCGyVNBT6E

[Massimo @Rainmaker1973]

This is a 3D HREM visualization of a human embryo in its fifth week.

It has a fishlike appearance because humans and fish share some DNA and a common ancestor.

[🎞️ Richard Behringer]

[Sandeep Gupta @GuptaLabUofA]

@Sergiu_P_Pasca @Nature Omg beautiful work! Congratulations!

[Sergiu P. Pasca @Sergiu_P_Pasca]

Today in @Nature, we report a new approach to studying human brain development and modeling disease in vivo.

Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations. Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.

To address some of these limitations and obtain more advanced functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex and hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.

We call these #xenocortical mice (XCX).

Nearly 7 years in the making. Congratulations to an extraordinary team and wonderful collaborators!

Link to the article below 👇

[Sandeep Gupta @GuptaLabUofA]

@SankarIITK @ANRFIndia @DBTIndia @agrawalmanindra @insa_academy @IITKanpur @mfcem_iitk Many congratulations, Sir! This is very exciting!

[Nature Japan @NatureJapan]

発生中のニューロンは移動の過程でDNA損傷を受けていた 脳形成の新たな仕組みを解明
見学美根子氏らの@Nature #OA #論文 #神経発生学 #神経科学 #分子生物学
Confined migration induces non-lethal DNA damage in developing neurons
https://t.co/JI0BGrCwbE
#オープンアクセス
@univkyoto @icems_ku

[eLife - the journal @eLife]

This 'important' Tools and Resources paper establishes a robust live-imaging toolkit to characterize excitatory and inhibitory synaptic dynamics during neuronal development. The methodology and quantitative data are 'convincing' and well validated.

https://t.co/24OcZ35AI2

[nature @Nature]

Lab meetings don’t always have to be so formulaic

https://t.co/2qURNTCOmS

[Ajeet Kumar @mrajeet]

I am excited to announce that our manuscript has been accepted in Nature Communications with the findings “Epitranscriptomic mechanisms governing axon projection and guidance during mammalian cortical neurogenesis”.

https://t.co/YeYUCL8kpf

[Sergiu P. Pasca @Sergiu_P_Pasca]

Our article, led by the remarkable Xiangling Meng, on establishing CRISPR screens in neural #assembloids and #organoids is on the cover of Nature Protocols today

[nature @Nature]

Nature research paper: Competing programs shape cortical sensorimotor–association axis development

https://t.co/SbqH4LykSW

[Sandeep Gupta @GuptaLabUofA]

@agnihotrinitin Congratulations Nitin, My best wishes!

[Sandeep Gupta @GuptaLabUofA]

@Ankita_JenaIITK Many congratulations, Ankita! My best wishes.

[Deepthi Muthukrishnan @deepthi03_krish]

Postdoctoral Research Fellow https://t.co/A6LGNN0M7E

[Ankita Jena @ankitajena91]

All smiles, endless motivation, a little chaos, a lot of science ✨🧪
Here’s to experiments, fun lab moments, and the amazing people behind them. Happy SB Lab Day! 💙

[UCLA Broad Stem Cell @UCLAstemcell]

For the first time, UCLA scientists @LTULab have mapped how Down syndrome reshapes the human brain before birth — uncovering surprising shifts in neuron development that may explain differences in brain size and cognition.
Read more ➡️https://t.co/wTZCXfavhk #BrainDevelopment

[Sergiu P. Pasca @Sergiu_P_Pasca]

Several staff scientist positions available in our lab at Stanford

More details and application at the link below

[Joseph G. Gleeson @jogleeson_ucsd]

Check out our new publication at https://t.co/Cj588ZClMc on Developmental organization of sensory and sympathetic ganglia, by @HarryKiv @shishenyxx and amazing collaborators.

[Cell Reports @CellReports]

Transcriptomic and spatial organization of mouse spinal cord projection neurons https://t.co/W36eVH6nu2

[SNEH HARSH @Sneh_Harsh]

Science often chases buzzwords, but studying sex determination showed me how a simple question can reveal deep biology. Discovering Zelda’s role was thrilling. Grateful to Erika Bach, my colleagues, and Artyom Kopp for the beautiful primer.https://t.co/LlaVudzK1f