Juliane Gust

Pediatric neurologist at Seattle Children's. Physician-scientist working at the intersection of cancer and the brain.

[Juliane Gust @GustJuliane]

Neurotoxicity (=ICANS) is common with CD19-directed CAR T cell therapy. We now show that biomarkers of glial and neuronal injury increase during ICANS in pediatric patients. Extremely high pre-CAR T levels correlated with prior chemo and radiation.
https://t.co/QrmC1Tzg1i

[Andy Shih @AndyShih_Lab]

We are guest editing a special issue of #Neurophotonics on #OpticalImaging of #Neuroimmune, #Neuroglial & #Neurovascular interfaces.

Publish reviews, primers, protocols, and tutorials for FREE. Please spread the word! @SPIEtweets

More info: https://t.co/xA7TYf11g5

[Andy Shih @AndyShih_Lab]

With more interesting articles in the pipe! Thank you to #Neurophotonics and @SPIEtweets for supporting the neurovascular community.

[Andy Shih @AndyShih_Lab]

This special issue is becoming a wonderful collection of reviews and protocols for cerebrovascular enthusiasts. Contributions from experts on #pericytes, #endothelium, #astrocytes, #fibroblasts, #ImmuneCells, #BrainClearance and advanced optical imaging!
https://t.co/om9IuK37aw

[Andy Shih @AndyShih_Lab]

Our study on mechanisms of #CarT neurotoxicity is published! Critical to understand the "dark side" of a revolutionary cancer treatment. Congrats to the amazing @FaulhaberLila and corresponding author @GustJuliane! @seattlechildren
https://t.co/BJDd6f65Na

[Nick Vitanza @VitanzaNick]

On behalf of our amazing team at @seattlechildren and @SCTherapeutics, I’m so proud to share preliminary results from the first trial delivering repeated intracranial doses of CAR T cells to children with brain and spinal cord tumors in @naturemedicine.

https://t.co/mkKQZrCMkQ

[Juliane Gust @GustJuliane]

@michelle_monje @GutmannLab @YuanPan3 A labor of love in the time of Covid...

[Michelle Monje 🟦 @michelle_monje]

Delighted to share this collaborative #CancerNeuroscience study with @GutmannLab, led by the brilliant @YuanPan3, demonstrating that retinal neuronal activity is required for the initiation and growth of optic #gliomas in a mouse model of #NF1
https://t.co/3NYkaZaRai

[Andy Shih @AndyShih_Lab]

#CarT #CellTherapy is a revolutionary cancer treatment, but neurotoxicity is a side effect for some patients.

Using a mouse model and #twophoton imaging, @GustJuliane and @FaulhaberLila show that plugging of brain capillaries is a potential mechanism.

https://t.co/ZpU6UGxrAo