Excited to share our latest work: Mitotic Cdc42 waves encode PI(3,4)P2 signaling and Golgi morphological state to control spindle scaling | Science Advances
https://t.co/ugwVMi2l0Z
Reinisch's lab work with @LabVanni, now is online in Cell!! Combining cryoEM and MD simulations, we reveal how the bridge-like lipid-transfer protein VPS13A coordinates with the scramblase XK to deliver and redistribute lipids to plasma membrane. https://t.co/OjrCbz5LPf
"I always wanted to be a scientist."
De Camilli’s journey from curious observation of nature as a child to understanding the molecular machinery of the brain has consistently been driven by an unwavering commitment to understanding life. @PDClab
https://t.co/pkjJBtrg5Y
Covill-Cooke, Hirashima, Kawano, Endo, Kornmann @UniofOxford and colleagues find that the ERMES #lipid-transporting complex, long-thought to be an obligate heterotetramer, can be replaced by only one component: mitochondrially tethered Mmm1. https://t.co/ClOi3Vigfq
#Mitochondria
Excited to share new preprint from the lab. Here we show that Pex30 reticulon homology domains generate membrane curvature and increase membrane thickness at ER subdomains that affects LD biogenesis.
https://t.co/2cfwbSa0zW
Yale University is recruiting a Staff Scientist II to join the Yale CryoEM Resource team and support our growing cryoEM community. Please take a look and share with anyone who may be interested: https://t.co/ay6ixzt4Kh
New in Cell Reports: SNAP-25 SNAREopathy variants (I192T/I192N) destabilize the SNARE complex C-terminus, ... Congrats and thank you to our collaborator Jakob B. Sørensen and co-first authors Victoria Vold & Jie Yang! https://t.co/6Ne0rjFk4f
Kim, Parolek, and Burd @YaleCellBio show that depletion of #cholesterol increases #sphingomyelin synthesis as a result of increased coatomer II–mediated endoplasmic reticulum-to-#Golgi#trafficking of #ceramide, the precursor to sphingomyelin. https://t.co/FgqgGIHuvo