The HW lab is in the Dept Physiology and Biophysics, and the Institute for Computational Biomedicine at Weill Cornell Medical College of Cornell University
The address system of the postal service for cholesterol traffic in the cell: how StarD4 uses PIP2 subtypes to recognize pickup and delivery sites
doi: https://t.co/K3XU4zmWeb
We are now officially into year 5 of the SARS-CoV-2 pandemic/endemic.
I gave a lecture to my virology class this Fall about the history of the pandemic through the lens of viral genotypes.
I thought I would share that lecture as a thread.
This is a long one.
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Really exciting to see previously described mechanisms and residues identified for efficacy and potency so beautifully re-presented in this new Science paper.
https://t.co/Dx17fO4yK0
The graphics are inspiring, even if the original findings are not cited. Bully for Science!
Hengyi Xie @HWeinsteinLab developed a powerful analysis of ligand-induced conformational rare events underlying the functional dynamics of the cell component protein that shuttles cholesterol (CHL) to membranes with low CHL content. Excellent example of allostery in action.
Allosterically coupled conformational dynamics in solution prepare the sterol transfer protein StarD4 to release its cargo upon ... https://t.co/n1u6Ybq4sN #biorxiv_biophys
"How lucky I was to have access to such incredible care...and to be the beneficiary of such amazing technology." Katie Couric on her recent diagnosis and treatment @WeillCornell by Dr. Lisa Newman (@LANewmanMD) from @WCMSurgery and the @WCMEnglanderIPM
https://t.co/tEcFUdYjCf
We hope you can join us on October 10, 2022, from 5:00 p.m.– 6:30 p.m. EST to learn more about the PhD programs at Weill Cornell Graduate School!
Registration is required: https://t.co/04U0tAgy3T
#openhouse#weillcornellgs#phd#research
"Another co-author had known about my contribution but chose not to credit me."
Don’t make early career researchers "ghost authors"—give them the credit they deserve, argues this #ScienceWorkingLife. https://t.co/NY4ulTM8dH @ScienceCareers
Khelashvili, G., Kots, E., Cheng, X. et al. The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase. Commun Biol 5, 990 (2022). https://t.co/L6wQu8X0JH
The NbIT and the TCF codes used to perform quantitative allostery analyses