I am ecstatic to announce that our #T2T paper (w/ @khmiga and @timp0) “Epigenetic Patterns in a Complete Human Genome” has been published in @ScienceMagazine (https://t.co/NwQOVSG2Jt). We believe this represents the most complete human epigenome yet described. A few highlights:
A special section in this week's issue of Science presents research by the Telomere-to-Telomere (#T2T) Consortium, which has completed a challenging 8% of the human genome left unresolved by the initial Human Genome Project.
Read more: https://t.co/aCBIarMm7u
What are the top 10 science visualization trends of 2021? I summarize ten notable changes I've seen in science figures in the past year. https://t.co/X3aeJG5bYC
Very excited for Next-Generation Genomics 2021 - and the wonderful list of junior speakers - later this month! Free registration is still open, and you can see a full agenda at https://t.co/M6YufsIaFP
Searching for computational Post-Doc positions in London. My skin is in Bioinfo/Comp Bio/Algo dev. Interested in repeats/omics/single-cell/spatial/imaging. Planning to change labs in 3-6mnths. orcid: https://t.co/xpakT31j9U. Reason: Current lab changing country. RT appreciated.
Proliferating cancer ells in culture videoed using a microscope. Cells were expressing the Fucci Cell Cycle Sensor. Magenta shows G1 and S. Green shows S, G2 and M.
#CellBiology#microscopy#SciArt
We associate unstable transgene expression with
1)integration site within highly variable & repressed genomic loci
2)genomic rearrangements induced in the host genome
3)enrichment of gene sets (ATR,MCM,ECM regulators,IF signaling) indicate cellular response to genomic stress 4/4
My 8th FA publication (last from @BOKU) on "Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations" is out now.
https://t.co/M4plcGvqgp. In this study ... 1/4
Information deduced from the random integration events, was used to identify genomic loci that potentially favor reliable and stable transgene expression and are reported for use as targeted transgene integration sites. Genome browser available at https://t.co/6DmQ41DMpq 3/4
Don't forget to tune into our free webcast with @NatureRevGenet featuring @annagloyn and @manoliskellis :
'Variant to function: Understanding disease mechanisms through integration of genetic data with epigenomic profiling'.
3 December 11am EST / 4pm GMT https://t.co/mtdw9X5pVl
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses (Zhang et al.) https://t.co/N9IKGLELNR