Winston Timp

[Winston Timp @timp0]

Interested in a #postdoc position to develop new sequencing methods? Come work with us! Work includes but is not limited to epigenetics, RNA mods, and single-cell/spatial transcriptomics. https://t.co/t29Lp12y88

[🇲🇽 Leonardo Collado-Torres @lcolladotor]

Winston @timp0 is guiding us through a #DNAm journey starting with his paper with Kasper D. Hansen from 2011

Nowadays with @PacBio and @nanopore long read DNA data you get DNAm for free!

5mC, 5hmC, brain 🧠 etc 🐇 🕳️

#BoG2026 @cshlmeetings

[EpiCypher, Inc. @epicypher]

At CSHL Biology of Genomes, May 5 to 9 🔬

See our poster on a high-throughput CUT&RUN workflow for rare immune cells, presented by Alli Hickman.

Not attending? Download it here: https://t.co/mL7pcBix9g

#CUTandRUN #Epigenetics

[EichlerLab @EichlerLab]

Noyes et al. apply long-read sequencing to autism families identifying increased numbers of germline & postzygotic mutations. Repetitive sequences like segmental duplications are hypermutable, especially in early embryo. @EichlerEE @uwgenome @hhmi_science https://t.co/KzDfKRBPw5

[Hasindu Gamaarachchi @Hasindu2008]

We have released slorado v0.5.0-beta and now it supports Nanopore DNA methylation calling (5mCG_5hmCG). Also 20% performance improvement to SUP models. Slorado supports both NVIDIA and AMD GPUs.

https://t.co/oAKvtHva2F

@bonson_wong @GaganGdas

[plasmidsaurus @plasmidsaurus]

POV: Your Sanger read is giving you confidence.
Meanwhile the rest of the plasmid: "we need to talk" 😅

[Steven Salzberg 💙💛 @StevenSalzberg1]

In 1998, I talked to Craig Venter about the feasibility of sequencing the human genome as a whole-genome shotgun project. Here's a story about that conversation https://t.co/ci0kyDHf43

[Hasindu Gamaarachchi @Hasindu2008]

The pre-print for Slorado and openfish is out. https://t.co/MFDJFjkXE3

You can do @nanopore basecalling with not just NVIDIA GPU, but also using a range of AMD GPU.

Would be useful since popular GPUs are now 💸💸💸💸(& hard to buy),

Work by @bonson_wong

[EichlerLab @EichlerLab]

We assembled the acrocentric short arms of 23 samples from a 4-generation pedigree, revealing unique mutational and recombination patterns from these highly repetitive regions that are usually excluded in the genetic analysis. Preprint: https://t.co/GFT9JQTLqB

[Winston Timp @timp0]

Finally, in CA1 engram (Fos+) neurons, we found upregulated isoforms (Egr1-201, Junb-201, Arpc2-201) and downregulated isoforms (Plp1-201). Notably, Arpc2-201—a learning-linked cytoskeletal isoform—suggests structural remodeling during engram activation.

[Winston Timp @timp0]

We are excited to announce our most recent preprint “Single-cell long-read sequencing of the experience-induced transcriptome” (https://t.co/Qts0K63OmJ) led by @sheridan in collaboration with Richard Huganir. A few highlights:

[Winston Timp @timp0]

For example Baiap2; which encodes an abundant scaffolding protein (Irsp53) in the postsynaptic density. We observed no differential expression, only differential splicing, resulting in loss of the C-terminal PDZ binding motif, needed for postsynaptic density localization.

[plasmidsaurus @plasmidsaurus]

🦖 Something HUGE just hatched.

Plasmidsaurus now offers RNA sequencing for gene expression analysis with:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results that let you explore changes in genes and pathways

Explore Plasmidsaurus RNA-Seq today.

[Javier Santoyo @jsantoyo]

Direct detection of 8-oxo-dG using nanopore sequencing. #DNAmodifications #Nanopore #Sequencing @nanopore @NatureComms
https://t.co/dSA7vsKyxX

[Rasmus Kirkegaard @kirk3gaard]

3050 Ti added.
https://t.co/5hcUn0uSeK

[Oxford Nanopore @nanopore]

Knowledge is power. In the studio, Matt Loose shared insights on rapid CNS profiling — and how one participant told him: “Even if the answer isn’t what you want, it’s better than not knowing at all.”

[EpiCypher, Inc. @epicypher]

NEW review article from Henikoff and Ahmad about emerging epigenomic mapping technologies to study chromatin regulation. Very comprehensive - great for beginners and experts alike!
https://t.co/KOOHsRLpFm

[plasmidsaurus @plasmidsaurus]

Ski fast…and sequence faster. Plasmidsaurus now lives in Germany! 🇩🇪

Overnight sequencing for ALL of Europe
Pickup ~4PM → Results 8AM

🦖 Dropboxes in 14 European countries...and the dino is looking for MORE! Request your free dropbox here: https://t.co/O7b20zz8fP

Sequence plasmids, amplicons, bacteria, libraries, yeast, AAV, microbiomes, eukaryotes…sequence everything. No primers needed.

Big love to Dr Jan Müller, PI at the Medical University Innsbruck, Austria, for starring in this video!

[Kimberley Billingsley @KimberleyBill10]

Excited & very lucky to be part of the Gates Sr. AD Fellowship ✨

Using CARD’s long-read epigenetic data 🧬 to build better predictive models of ADRD & making all models & methods openly available (open science FTW!🔓).

Looking forward to collaborating with this awesome group!