Heidi and Harlow

[dior ✞ @deeore5]

the older i get the heller the no

[Heidi and Harlow @HeidiMdx]

@GSantanacxyt @Suzycue681 @janekin24 @t_NYC Bestie 2.12 means one hantavirus infected person will infect 2-3 people that come into contact with them. The in reference to our other reply guy, the plague’s r value was around 1.5 to 1.7, so you should stop being a dumbass.

[Heidi and Harlow @HeidiMdx]

@zoeycyberkitty @latkedelrey Girl, EBV will fuck your ass up and maybe give you B cell lymphoma eventually, or MS. Chill and let this girl speak.

[Gina Darling @MissGinaDarling]

Calling it “the jab”

[Merriam-Webster @MerriamWebster]

This is coming from a place of warmth and acceptance…

-It’s ‘sleight of hand’
-It’s ‘bated breath’
-It’s ‘lo and behold’
-It’s ‘one fell swoop’
-It’s ‘brass tacks’
-It’s ‘free rein’

[derek guy @dieworkwear]

Tweet: "fuck this brownie is so good rn"

Ten immediate replies: "Well said. Brownies combine eggs, granulated sugar, and cocoa powder in a way that quietly elevates the culture. They're not just a snack, they're a vibe."

[Heidi and Harlow @HeidiMdx]

@Michaelfiore I bet your greenhouses are looksmaxxing right now and I’m here for it.

[David Leavitt 🎲🎮🧙‍♂️🌈 @DavidLeavitt]

Why the hell is there a banner of Charlie Kirk on the Department of Education?

Why is CHARLIE KIRK’s face on the Department of EDUCATION.

WHY IS CHARLIE KIRK ON THE DEPARTMENT OF EDUCATION?!?!?!?

[Heidi and Harlow @HeidiMdx]

@RVAwonk This enrages me. People need to shut the fuck up a lot more.

[Angry Staffer @Angry_Staffer]

Just saying, but when people are trying to do everything they can to prevent you from voting, that’s when you absolutely need to vote.

Ready to make this the biggest midterm turnout in history?

[Heidi and Harlow @HeidiMdx]

@indigos_aura @8Cherrington403 @RoyIsThaTruth They’re star tattoos

[Heidi and Harlow @HeidiMdx]

@singingsox Yes, they auto refill my propranolol too without asking and it pisses me off.

[goma @soigomaa]

The fact that people need a dead man's files to believe a thousand living women... tells you everything about whose voices they don't.

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Ryan Grim @ryangrim]

To be clear about what this depicts: An immigration officer threw a woman onto the ground. Alex Pretti, a registered nurse on scene as a legal observer, is filming and goes to help the woman up. He is then pepper sprayed and thrown to the ground for no discernible reason. Many officer surround and assault him; one removes his firearm, which police say appears to have been legally registered. They then execute him with a hail of bullets.

They are, objectively speaking, both cowards and criminals, while Pretti is what we teach people an American ought to be.

[⚡︎ @_sorrengailll]

yo what the FUCK did Apple do to the iPhone keyboard because I genuinely feel like I’m losing my mind typing these days

[Elmo @elmo]

Don't forget to take a nap today! Elmo knows you're going to need it!

[alli @sonofalli]

when the meeting gets cancelled

[Papa Woof und Krampus und Bleaken @woofknight]

My toxic trait is telling people I'm down for anything when in reality I mean not after 8 pm, food should be involved, and it also depends on the weather, the parking situation, and how tired I am