@Adrian_H Loading control band "smiling" upward smearing at far left and right wells are normal. "Smiling" artifacts in the middle wells is unusual and indicates that these are two gels spliced together?
@peiferlabunc @CWolberger You can trace the general path of the disordered H3 tail to the Haspin active site in a low-pass filtered map! The final few residues that make contact with the active site are well resolved after performing a local refinement of Haspin alone!
I am thrilled to share a preprint of my PhD project revealing the cryoEM structure of Haspin kinase bound to nucleosome at a DNA supergroove!
https://t.co/ZjVjJMp2Y6
@AHollandLab@CWolberger@SanimRahman4 This project was conceptualized as a way to provide a useful and fun cryoEM experience to Hopkins Summer Academic Research Experience (SARE) scientist Stacy Vasquez during her senior year of high school last summer. We were really surprised by the results...
I am very grateful to the amazing scientists and coauthors. You are all awesome, and I am so proud of our discovery! @AHollandLab (Colin Gliech), @CWolberger lab (Xiangbin Zhang, @SanimRahman4), Baltimore Polytechnic Institute (Stacy Vasquez).
@dabiophysicist Thanks! Many of the nicest looking pictures of the eclipse are also composite images from many different photos. These here are single photo images, so that's probably why they look more natural!
I managed to get some awesome photos of the 2024 solar eclipse. What an amazing experience...
The reddish solar prominence at the bottom of the sun (which was visible to the naked eye) is ~40,000mi long or ~5 times the diameter of Earth 🤯