Andrew Holland

Director @AmgenOncology, ❤️ @JohnsHopkinsMBG

[Andrew Holland @AHollandLab]

Excited to share a new Perspective published today in @NatureCellBio, written with Colin Gliech

In this piece, we discuss how cells leverage biological “clocks” during mitosis to protect genome integrity—a fascinating layer of regulation in cell division.
https://t.co/RrqEN9sjmS

[Andrew Holland @AHollandLab]

I love watching Walnut come alive during the finishing process

[Andrew Holland @AHollandLab]

Also, check out the accompanying paper from the @oegemadesai_lab https://t.co/mJhhd86il0

[Andrew Holland @AHollandLab]

Interested in E3-Ub ligase regulation? Check out the latest paper from our lab: https://t.co/3FjXEmnML3. Big congrats to @PeterYeowZY who conceived and drove this study!

[Journal of Cell Biology @JCellBiol]

Centriole structural integrity defects are a crucial feature of hydrolethalus syndrome, say Ana Curinha (@ana_curinha), Andrew Holland @AHollandLab @JohnsHopkins and colleagues: https://t.co/dtooFEF3GG

#Centrioles #Cilia

[Andrew Holland @AHollandLab]

Check out our latest work using the AID2 system to control the levels of an essential protein in mice. Congrats to the entire team, especially @SladkyValentina and Margaret Strong

https://t.co/DBOfiVJdsK

[Andrew Holland @AHollandLab]

Check out our latest paper in @JCellBiol. Congrats to the entire team, especially @ana_curinha

[Journal of Cell Biology @JCellBiol]

HLS, an autosomal recessive #ciliopathy, is associated with a mutation in the centriole protein HYLS1. Curinha, Holland et al @JohnsHopkins show that HYLS1 mutant mice exhibit developmental abnormalities, with #centriole integrity & #cilia assembly defects https://t.co/3GQybPtJUD

[Rajini Rao @madamscientist]

BREAKING: Johns Hopkins along with 12 peer institutions and Assoc of Amer Univ sues to stop drastic cuts in NIH funding. This is separate from lawsuit brought by 22 states, which also includes Maryland. Hopkins prez cites our 600 clinical trials that would be crippled by the cut.

[Lydia Finley @lydfinley]

Things I wish more people knew about doing science in the US (thread):

[Andrew Holland @AHollandLab]

Three papers accepted in one week. That won’t ever happen again….

[Andrew Holland @AHollandLab]

We got a puppy 😍

[Elizabeth Chen @EChenLab]

Curious about how cells generate mechanically stiff invasive protrusions from branched actin filaments? Check out our paper published today in @NatureCellBio!

Congratulations to Yue Lu and all co-authors for a beautiful piece of work!

https://t.co/DYsJq48Qag

[Andrew Holland @AHollandLab]

@MarinaSchapfl @NatureComms @villunger Congrats Marina!

[Centrosome Papers @CentrosomePub]

Mesoscale regulation of MTOCs by the E3 ligase TRIM37 https://t.co/bktrvMOWLC

[Peter Yeow @PeterYeowZY]

Full preprint here: https://t.co/m3IPtbRPx8 we welcome feedback and questions, thanks! 🙏

[Peter Yeow @PeterYeowZY]

📝Preprint! 1️⃣Question: How are large MTOC structures regulated by an E3 ligase? 🧵In 2020, we showed TRIM37 suppresses surrogate MTOC structures in 17q23 cancers, see ⬇️). But TRIM37 also regulates centrosomes and pathological MTOCs (Gönczy/Oegema/Desai labs). How?? ➡️our model

[Peter Yeow @PeterYeowZY]

2️⃣ Model: My work at @ahollandlab suggests a shared blueprint within the TRIM family for assembly regulation. Akin to TRIM5a in HIV restriction, TRIM37 employs an assembly-driven E3 activation process but is uniquely tailored for MTOC control via its TRAF domain. ➡️Impact

[Andrew Holland @AHollandLab]

Cilia are beautiful

[Andrew Holland @AHollandLab]

@DeryaTR_ @JSheltzer That’s a pretty good experiment. A PDX panel would be my choice.

[Andrew Holland @AHollandLab]

@goleylab @ekreils Congrats Erin! So happy for you.