⏳T-minus 3️⃣ months until @ABUrology Part I Boards ➡️ great time to start or boost your exam prep with the fully updated 2026 edition of @HighYieldUro 🚀
⏳T-minus 3️⃣ months until @ABUrology Part I Boards ➡️ great time to start or boost your exam prep with the fully updated 2026 edition of @HighYieldUro 🚀
In cisplatin-ineligible patients with muscle-invasive bladder cancer, enfortumab vedotin–pembrolizumab plus surgery led to better event-free survival (74.7%, vs. 39.4%) and overall survival (79.7%, vs. 63.1%) than surgery alone at 2 years. Full phase 3 KEYNOTE-905 trial results and Research Summary: https://t.co/bzVbmJXHMD
We keep rediscovering the same truth—hormonal biology works. Estrogen returns in prostate cancer, this time via patches, with noninferior outcomes and potentially better tolerability. Not new—just better applied. Study in @NEJM by the #Stampede group/@MRCCTU
https://t.co/Pq17ahdPgu
3 studies testing Perioperative immune bases therapy (EVP or Gem/Cis/Durva) in muscle invasive bladder all have shown an OS advantage vs standard of care. KN905 (EVP) is distinct in that it’s in a cisplatin ineligible population (accounting for the poor performance of the control arm). It’s also a smaller trial. The control arm of KN-B15 performed slightly better than NIAGARA (Gem/cis for both), but the trials are otherwise similar. The pCR in the EVP trails and the consistent efficacy of EVP is striking. #GU26
JUST IN: @US_FDA approved PARP inh Niraparib +abi/pred for BRCA2-mutated (BRCA2+) metastatic castration-sensitive prostate cancer (CSPC). Data based on AMPLITUDE trial showing rPFS benefit in the overall/BRCA population. Most benefit came from the BRCA2+ tumors: HR 0.46 (vs 0.88). Paper in @NatureMedicine led by @AttardLab @DRathkopf --Approval where therapies work Best!
Link: https://t.co/DgAuE5idLb
The FDA approval of EV + Pembro in cisplatin ineligible muscle invasive bladder is based on pCR=57% & OS HR of 0.5 vs cystectomy alone. Initial systemic therapy rather than surgery is now preferable for all eligible pts. I suspect this is not the last we hear from EVP in MIBC.
🚨RC48-C016 @NEJM
🇨🇳 484 pts w/ untreated HER2(+) locally advanced or M1 UC ➡️ compared to chemo, combination Tx w/ disitamab (mAb to HER2) - vedotin & toripalimab (PD-1🛑) doubled med PFS (7 vs 13 mos) and med OS (17 vs 32 mos) & ⬇️ G3+ AE’s ✅ https://t.co/LhYPHNAjVU
🚨 IMVigor 011 @NEJM
After cystectomy for MIBC, ctDNA-guided adjuvant Atezolizumab (PD-L1 inhibitor) extended med DFS (10 vs 5 mos) and med OS (33 vs 21 mos) over placebo ✅ https://t.co/cdafbq5Zme
🚨LITESPARK-015 @NEJM
🌎🌍 72 patients w/ advanced, unresectable, and/or metastatic Pheochromocytoma or Paraganglioma ➡️ all got Belzutifan (HIF-2a inhibitor) ➡️ at med f/u 30 mos, obj response rate and disease control were 26% and 85% ➡️ FDA-approved ✅ https://t.co/xMRmpfhIj9
JUST IN: Tar200 now @US_FDA approved based on SunRise-1 phase 2 trial in BCG unresponsive NMIBC.
-Intravesical form of Gemcitabine
- CR: 82.4%/grade ≥3 AE 12.9%
- DFS 70.2% at 12m
- 51% of CRs with DOR ≥ 12 months.