Hiller Lab

Group of Prof Sebastian Hiller. Structural Biology Research Group @biozentrum @Unibasel. Unravelling Biomolecular Mechanisms. (run by students)

[Basile Wicky @BasileWicky]

New lab preprint! We used design to sample protein space, and developed a HT NMR pipeline to analyze 384 designs; a first glance into seq-struct-dynamics at scale! An exciting collaboration with @HillerLab, and @DlanAbr's first paper! https://t.co/HCJNUNKFSU

[Hiller Lab @HillerLab]

Great Collaboration between our lab and the @BasileWicky lab 🚀

[Dylan Abramson @DlanAbr]

First PhD paper is out 👀We built an automated pipeline to do NMR on de novo proteins at scale. We believe designed proteins can be a lens for fundamental biophysics
https://t.co/Hq1ovtLRNl

[Hiller Lab @HillerLab]

We are thankful to our collaborators from the @Spang_Lab and @MaierLab @Biozentrum @UniBasel

[Hiller Lab @HillerLab]

New paper alert! Stellar work by brilliant lead first author @annaleder_ together with project leader @guillaumemas2 reveals a groundbreaking discovery: PDIA6 forms multi-chaperone condensates creating "folding factories" in the ER. https://t.co/TvNsHJ3anB

[Hiller Lab @HillerLab]

These condensates could revolutionize our understanding of protein folding and inspire new therapies for misfolding diseases like diabetes and cancer. A new era for targeting ER function! #Biomedicine #Therapeutics

[Hiller Lab @HillerLab]

Last day for our summer student @Shreyan11_11, who has done great work during his one and a half months in our lab working on the Hsp70 functional cycle! If you are looking for a PhD student in the next few months, @Shreyan11_11 will be a great fit for any lab!

[Hiller Lab @HillerLab]

Congratulations to PhD student Marta and NMR Facility Manager Thomas for the publication of their great work on Photo-CIDNP in JACS ! https://t.co/GEHFffsZS1

[Hiller Lab @HillerLab]

Great pictures!

[नील सरोवर भवेश Neel Sarovar Bhavesh 🇮🇳 @neelbs]

It was great meeting Sebastian Hiller after 18 years at the joint #APNMR-@NmrsIndia meeting at @IISERPune. We worked in the same lab for five years, sharing the same office space, HPK-G13.

The first photo is from 06/2025, and the second is from 04/2005.

[Biozentrum, University of Basel @biozentrum]

A Day Dedicated to Science: On June 12, the @biozentrum community gathered for its traditional symposium. Bringing together around 300 Biozentrics, the event showcased a broad spectrum of cutting-edge research while fostering interdisciplinary dialogue and collaboration.

[Hiller Lab @HillerLab]

Congratulations to @annaleder_ receiving the Shepherd price for her PhD work at today’s @biozentrum symposium @biozentrum_phds . Stay tuned for the official paper release in the coming weeks.

[Hiller Lab @HillerLab]

Our data reveal that calcium doesn’t affect the cycle, but combined with ADP accumulation it creates off-pathway states that prolong the nucleotide-bound lifetimes. This changes Hsp70’s function extending client protein interaction times — a new layer of cellular regulation!

[Hiller Lab @HillerLab]

Introducing in-cyclo NMR, a new method led by @GuillaumeMas2 at @biozentrum (@NatureComms)! This method combines high-resolution NMR with ATP regeneration & phosphate removal to resolve kinetics & dynamics of molecular machines - all in one experiment! https://t.co/cGCLUs9dCQ

[Hiller Lab @HillerLab]

This versatile in-cyclo NMR platform is adaptable to study diverse ATP-driven molecular machines beyond Hsp70 — enabling precise dissection of functional cycles, allosteric regulation, and the effect of cofactors or co-chaperones at unprecedented resolution. #MolecularMachines

[Hiller Lab @HillerLab]

Tired of costly cloning software? Try IVA Prime: a free, game-changing tool for automated primer design in IVA cloning! Simplify complex cloning with one click, reduce errors, and save time. Visit https://t.co/AmYWbwd6KG. https://t.co/4ZSF33feV6 collaboration with @JGarciaNafria

[Hiller Lab @HillerLab]

Check out our latest story on the cryoEM structure of the BAM holo insertase complex! Out in @ScienceAdvances (https://t.co/VthJBGHosr)

[Hiller Lab @HillerLab]

Big week ahead for our lab! @annaleder_ presents at the 1.2 GHz inauguration in Zurich, and @GuillaumeMas2 speaks at @ENC_Conf (5:05pm PT) in Asilomar #ENCISMAR2025. Expect groundbreaking ideas on enzymology, molecular chaperones, LLPS, & ER biology. Don’t miss it!

[Hiller Lab @HillerLab]

Happy to announce the release of our collaboration with the @JenalLab! @GuillaumeMas2 led the NMR analysis, identifying the toxin’s product and unravelling the enzymatic properties of the toxin-antitoxin system.

[Biozentrum, University of Basel @biozentrum]

Researchers @JenalLab and @HillerLab have discovered how a dangerous human pathogen causing pneumonia uses a kind of molecular "sleeping pill" to enter a dormant state to persist antibiotic treatment. @UniBasel_en @NCCR_AntiResist @snsf_ch @EMBOPress https://t.co/GiuQDjescy