HittingerLab

Biodiversity | Biochemistry | Biotechnology | Functional, Ecological, and Evolutionary Genomics | Moderated by current lab members

[HittingerLab @HittingerLab]

It's been awhile since we posted here, but we have an opening for postdoctoral training! Please apply by 15th August 2025 for full consideration. Here is the ad: https://t.co/rrx3YAs5NF

[HittingerLab @HittingerLab]

For more information and to see our previous winners, see our website https://t.co/jQjey0oAcI

@UWEvolution

[HittingerLab @HittingerLab]

UW-Madison Evolution Seminar Series' Early Career Award is open for applications until November 30th, 2024. This is a great opportunity to showcase your work at our seminar! 🦡⚗️

Postdocs and grad students in evolutionary biology are encouraged to apply: https://t.co/bQGbgxl65T

[Great Lakes Bioenergy Research Center (GLBRC) @GLBioenergy]

🥐 John Crandall, a postdoc in the @HittingerLab, works with yeasts both in and outside of the @UWEnergy lab as a home brewer and baker.

Find out what makes a yeast boring or interesting in his colorful spotlight:
https://t.co/A0xcVDKvCK

#postdoc #microbiology #uwmadison

[ASBMB @ASBMB]

🍺Q: What makes a yeast variety suitable for lager beer rather than ales?
🍻A: Yeast that ferments best at cool temperatures. Industrial lager brewers favor S. pastorianus.
🧬Learn about research from the @HittingerLab for more on the genetics of #beer: https://t.co/esE95cMGXc.

[HittingerLab @HittingerLab]

See the full paper here:
https://t.co/dzTJjWFe9Q

Led by Dr. John Crandall (former @uwgenetics PhD student and current @GLBioenergy postdoc) with Dr. Xiaofan Zhou and @RokasLab

[HittingerLab @HittingerLab]

How can a yeast sugar transporter find a new function?
In our new paper out now in @MolBioEvol we look at a recent evolutionary innovation in an alpha-glucoside transporter in S. eubayanus and find that multiple simultaneous mutations are required for this new function!

[HittingerLab @HittingerLab]

Zooming out to look at the Major Facilitator Superfamily across diverse yeasts, we find that these specialized alpha-glucoside transporters likely evolved from a generalist ancestral transporter.

[UW Energy Institute @UWEnergy]

Happy Halloween from the Wisconsin Energy Institute!

[HittingerLab @HittingerLab]

This work was a great collaborative effort led by @MarieClaireHar2 with @DOpulente @shenxingxing1 @MarizethGroene1 @RokasLab @Lab_LaBella

[HittingerLab @HittingerLab]

See our new article in which we developed an Ontology of Yeast Environments.🌱This hierarchical framework allows for new systematic analyses and insights into the evolution, ecology, and diversity of yeasts!💡https://t.co/8SftnR2FSM

[HittingerLab @HittingerLab]

This is based on genome-informed higher ranked classifications led by @MarizethGroene1 as part of the https://t.co/0q2BfbiWAa project

https://t.co/Ltk3kHDyFI

[HittingerLab @HittingerLab]

Check out @NCBI Insights blog on updating the yeast taxonomy:
https://t.co/vahHGdTbqt

[bioRxiv Microbiology @biorxiv_micrbio]

Machine learning uncovers gene families impacting oxidative stress resistance across yeasts https://t.co/zNZa4QIod0 #biorxiv_micrbio

[HittingerLab @HittingerLab]

How can yeast fermentation workflows be optimized in biorefineries for isobutanol production?

See our @GLBioenergy collaborative work on using gamma-valerolactone (a renewable green solvent) in biomass pretreatment to achieve high titers of isobutanol

https://t.co/kuYTOUTIyg

[HittingerLab @HittingerLab]

Huge thanks to our @GLBioenergy and @RokasLab collaborators!

[HittingerLab @HittingerLab]

How do yeasts resist oxidative stress? We used machine learning to identify gene families that are predictive of ROS resistance across the yeast subphylum.

Check out the preprint led by @UWBiochem undergrad Kat Aranguiz and postdoc @Linder_surprise

https://t.co/UtX8ZAeAZq

[HittingerLab @HittingerLab]

The most predictive gene families included reductases and were enriched for cell wall-related genes. After interrogating the model to make specific hypotheses about how manipulating gene families would impact ROS resistance, we also validated their impact using two yeast species.

[HittingerLab @HittingerLab]

Huge thanks to our @GLBioenergy and @RokasLab collaborators!

[HittingerLab @HittingerLab]

The most predictive gene families included reductases and were enriched for cell wall-related genes. After interrogating the model to make specific hypotheses about how manipulating gene families would impact ROS resistance, we also validated their impact using two yeast species.