For years Blastic Plasmacytoid Dendritic Cell Neoplasm (BPCDN) was taught to derm and pathology residents with the mnemonic CD123456; referencing the common immunophenotype CD 123 + CD4 + CD 56 but the diagnostic criteria were updated by the WHO in 2022. Here's the new criteria:
* Table from: Lee YJ, Kim Y, Park SH, Jo J. Plasmacytoid dendritic cell neoplasms. BR 2023;58:S90-S95. https://t.co/z7D5WEshd0
When taking office in 2025 RFK Jr shut down
- The team responsible for dealing with cruise ship outbreaks
- One of the only labs in the world capable of Ebola research
How's that workin out?
In my 1977 study of 128 open lung biopsies from patients with sarcoidosis, granulomatous vasculitis was observed in 69% of the biopsy specimens (PMID: 576782). In a subsequent study published in 1999 the authors found granulomatous vasculitis in 100% of 40 patients with sarcoidosis studied at autopsy. (PMID:1427751 ).
Despite the high incidence of granulomatous vasculitis in the lungs of patients with sarcoidosis demonstrated by surgical lung biopsies and autopsy, this lesion is rarely seen in transbronchial lung biopsies.
Granulomatous vasculitis can occasionally be seen in conditions other than sarcoidosis as shown in the accompanying images.
What to call a soft tissue tumor resembling fat-free spindle cell lipoma, low-grade fibromyxoid sarcoma (or SEF) and SFT?
Read more about this upcoming #BSTPath WHO6 📘 entity in this open access IJSP paper https://t.co/wsbMTUX9jg
🔬clue: cleft-like, gaping spaces!
#PathTwitter
Just reported the second example I’ve seen of this unusual and possibly clinically insignificant Rosai-Dorfman phenomenon in a young patient’s eosinophil-rich inflammatory nasal polyp #ENTpath#Pathtwitter@ENTpathology
Advancing care with precision during Retinoblastoma Awareness Week 🎗️
@JWHarbourMD shares how innovative, eye-focused therapies are changing outcomes for patients in this MedBlog.
🔗 Read now: https://t.co/AF2VKdvEYk
#UTSWOphthalmology#Retinoblastoma#OcularOncology#UTSW