Hugo Farne 🫁

Respiratory 🫁 doctor. Specialist interest in asthma

[Hugo Farne 🫁 @HugoResp]

Tweetorial for UK docs using @CernerUK PowerChart (not sure if this format will be useful but here goes)

First a question: how would you rate yourself as a PowerChart user?

[Hugo Farne 🫁 @HugoResp]

@HMRCcustomers Sorted now - thanks

[Hugo Farne 🫁 @HugoResp]

@HMRCcustomers if one receives a giro credit for a tax refund & it expires before it is deposited (not many banks have counters to accept these), how do you get one reissued (or a bank transfer instead)?

Online assistant suggests calling. After 1h, phone assistant says online 🤯

[Hugo Farne 🫁 @HugoResp]

@HMRCcustomers Self assessment tax refund

[ERS publications @ERSpublications]

This study validates a previously reported bronchial signature of bronchiectasis in nasal epithelium. Changes in gene expression and cell-type composition associated with radiological bronchiectasis are similar across both bronchial and nasal epithelia. https://t.co/g7NwClYcoy

[ERS publications @ERSpublications]

European Respiratory Journal: TSC2 mutations are the main cause of sporadic LAM in nearly all patients https://t.co/SiyT82Ke8j

[brian lipworth @doclip1]

Inhaled anti-TSLP for persistent asthma -Phase 1 study
https://t.co/zUgROlymcm

AZD8630 well tolerated with low incidence of ADA

Suppression of FeNO indicating effects on airway epithelial cells and downstream IL13 signalling

[Charles Swanton @CharlesSwanton]

Excited to share our ‘Evolutionary characterization of #LungCancer metastasis’ in #TRACERx & #PEACE, published today in @Nature: a decade spanning effort led by the Jamal-Hanjani lab, @SwantonLab, @NickyMcGranahan & @ZaccaSimo at @uclcancer & @TheCrick. Link below

[Hugo Farne 🫁 @HugoResp]

@ProfJDChalmers What about patients not eligible eg non-eosinophilic - what’s in the pipeline for them?

And are there any plans to trial DPP1 inhibitors in COPD? (Question for both you and Mona!)

[Hugo Farne 🫁 @HugoResp]

@ProfJDChalmers How do we ensure we select the right patients to see the benefit seen in trials - and ensure we can continue to prescribe these drugs? 2/

[Hugo Farne 🫁 @HugoResp]

@ProfJDChalmers Very nice work!

Azurocidin-1 also elevated in some patients with asthma. I wonder if DPP1 inhibitors might be effective in airways disease, if we can appropriately select patients?

[James D Chalmers @ProfJDChalmers]

A study 10 years in the making, just published in @LancetRespirMed
How do DPP1 inhibitors really work in bronchiectasis?
We show a novel mechanism for treatment efficacy, by inhibiting Azurocidin-1, a ciliotoxin, DPP1i can enhance mucociliary clearance.
https://t.co/eVR7fhgW7w

[James D Chalmers @ProfJDChalmers]

ECCMID 2026
No induction of resistance over 6 months with monoclonal antibody therapy against pseudomonas in bronchiectasis
Encouraging beneficial changes to the microbiome too
Encouraging early results presented by @beccahull_

[James D Chalmers @ProfJDChalmers]

Inhaled immunoglobulin as a novel treatment for bronchiectasis: results from a phase 1 trial

Inhaled immunoglobulin G was associated with low rates of adverse events and reduced airway bacterial burden. Encouraging results! Online now at @ATSBlueEditor
https://t.co/4p6TayHxLq

[Charles Swanton @CharlesSwanton]

People often ask how breakthroughs occur in cancer biology-often the story is more complex - the survival plot for myeloma outcomes is extraordinary - improvements come about in incremental steps - in my lifetime treatment of Myeloma has almost transformed into a curable disease

[brian lipworth @doclip1]

No cigar for Rilzabrutinib (BTK inhibitor) in mod-sev asthma (Ph 2)

Futility on primary EP of loss of asthma control upon withdawal of ICS/LABA
https://t.co/NgztQA48io

[Hugo Farne 🫁 @HugoResp]

It makes no sense to me to close roads and dig them up just before a 4 day bank holiday with the disruption inevitably being extended by 4 more days?

@MayorofLondon can you make it prohibitively expensive to do this?

@CadentGasLtd @UKPowerNetworks @thameswater

[Don Sin @donsin4]

Just counting blood vessels on #CT of #COPD pts predict lung function and its decline, exercise capacity & symptoms; better imaging biomarker of disease burden in #COPD than anything else we have https://t.co/lk0IVuLqJF

[Hugo Farne 🫁 @HugoResp]

I suspect it is easier signing up for locum agencies - which are more costly for Trusts and by extension, taxpayers.

2/

[Hugo Farne 🫁 @HugoResp]

@DHSCgovuk @wesstreeting
Resident doctor strikes have highlighted all sorts of issues.

Not least the inefficient process to sign up to the bank to locum. Why do occupational health checks have to be in person? And why can’t in person ID checks be at the nearest hospital HR?

1/